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Neurology FREE

Robert J. Joynt, MD, PhD
JAMA. 1990;263(19):2660-2661. doi:10.1001/jama.1990.03440190116061
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A major theme in neurology for the last several years has been clinical trials of therapy for disorders that were thought to be untreatable. The course of Parkinson's disease, for example, has been greatly modified by the introduction of therapies that increase activity in the dopaminergic system. During this last year, another approach to this disease has been undertaken through attempts to delay and slow its manifestations. The variable course and heterogeneous manifestations of Parkinson's disease make clinical trials difficult. However, a multicenter controlled clinical trial with many safeguards was devised.1 The clinical trial is still in progress, but the interim results show that 10 mg/d of selegiline (Deprenyl), a monoamine oxidase inhibitor, slowed the end point, which was a decision to treat the patient with levodopa therapy. The treatment also had a significant effect in slowing the time until it was necessary for the patient to give up

REFERENCES

Parkinson Study Group.  DATATOP: a multicenter controlled clinical trial in early Parkinson's disease . Arch Neurol . 1989;;46:1052-1060.
The Parkinson Study Group.  Effect of Deprenyl on the progression of disability in early Parkinson's disease . N Engl J Med . 1989;;321:1364-1371.
Lindvall, Rehncrona S, Brundin P, et al.  Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease: a detailed account of methodology and a 6-month follow-up . Arch Neurol . 1989;;46:615-631.
Council on Scientific Affairs and Council on Ethical and Judicial Affairs.  Medical applications of fetal tissue transplantation . JAMA . 1990;;263:565-570.
Weinsbhenker BG, Hader W, Carriere W, Baskerville J, Ebers GC.  The influence of pregnancy on disability from multiple sclerosis: a population-based study in Middlesex County, Ontario . Neurology . 1989;;39:1438-1440.
 PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I . Science . 1989;;246:821. Technical Commentary.
 Advances in medical imaging . Ann Intern Med . 1990;; 112:203-220. UCLA Conference.
Cerebral Embolism Task Force.  Cardiogenic brain embolism: the second report of the Cerebral Embolism Task Force . Arch Neurol . 1989;;46:727-743.
Baker EL, Ehrenberg RL.  Preventing the work-related carpal tunnel syndrome: physician reporting and diagnostic criteria . Ann Intern Med . 1990;;112:317-319.
Katz JN, Larson MG, Sabra A, et al.  The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings . Ann Intern Med . 1990;;112:321-327.
Goldstein M.  Traumatic brain injury: a silent epidemic . Ann Neurol . 1990;;27:327.

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Parkinson Study Group.  DATATOP: a multicenter controlled clinical trial in early Parkinson's disease . Arch Neurol . 1989;;46:1052-1060.
The Parkinson Study Group.  Effect of Deprenyl on the progression of disability in early Parkinson's disease . N Engl J Med . 1989;;321:1364-1371.
Lindvall, Rehncrona S, Brundin P, et al.  Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease: a detailed account of methodology and a 6-month follow-up . Arch Neurol . 1989;;46:615-631.
Council on Scientific Affairs and Council on Ethical and Judicial Affairs.  Medical applications of fetal tissue transplantation . JAMA . 1990;;263:565-570.
Weinsbhenker BG, Hader W, Carriere W, Baskerville J, Ebers GC.  The influence of pregnancy on disability from multiple sclerosis: a population-based study in Middlesex County, Ontario . Neurology . 1989;;39:1438-1440.
 PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I . Science . 1989;;246:821. Technical Commentary.
 Advances in medical imaging . Ann Intern Med . 1990;; 112:203-220. UCLA Conference.
Cerebral Embolism Task Force.  Cardiogenic brain embolism: the second report of the Cerebral Embolism Task Force . Arch Neurol . 1989;;46:727-743.
Baker EL, Ehrenberg RL.  Preventing the work-related carpal tunnel syndrome: physician reporting and diagnostic criteria . Ann Intern Med . 1990;;112:317-319.
Katz JN, Larson MG, Sabra A, et al.  The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings . Ann Intern Med . 1990;;112:321-327.
Goldstein M.  Traumatic brain injury: a silent epidemic . Ann Neurol . 1990;;27:327.
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