In Reply.— Dr Jacobson implies that if our sample size were adequate we would have shown an effect of nicotine gum. We would remind our readers that the 2% to 5% increases in quit rates with nicotine gum in our study were not reliable. In addition, if one uses meta-analytic techniques1 to combine the results from ours and the two prior studies with 1-year follow-ups2,3 to increase the sample size, the combined results do not show a significant difference between nicotine and placebo gum. To detect a small increase in quit rates with adequate power (β =.80) and a conservative type II error (a =.05) would require very large sample sizes (eg, 2840 for the 7% vs 10% difference reported in our trial) and this is why we decided not to try to detect such a difference.4Dr Jacobson states that more intensive treatment and follow-up increase quit
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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