Innovations in Monoclonal Antibody Tumor Targeting: Title and subTitle BreakDiagnostic and Therapeutic Implications FREE

Jeffrey Schlom, PhD

[+] Author Affiliations

Reprint requests to the Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bldg 10, Room 8B07, Bethesda, MD 20892 (Dr Schlom).

JAMA. 1989;261(5):744-746. doi:10.1001/jama.1989.03420050094047

Text Size: A A A

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

SELECTED CASE A 33-YEAR-OLD woman presented with a history of infertility following a normal pregnancy three years previously. A hysterosalpingogram showed a fallopian tube blockage. She underwent an exploratory laparoscopy with findings that suggested chronic pelvic inflammatory disease. During a laparotomy for tubuloplasty she was found to have a ruptured adenocarcinoma of the appendix, with tumor coating the liver, diaphragm, and peritoneum. The peritoneal cavity was washed out. She remained asymptomatic, with no progression of disease seen during laparoscopy one year later. Three years later, during a physical examination, she was found to have a large, pelvic recurrence and underwent abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and debulking of gross tumor, with residual tumor left behind. Radiographic evaluation, including a computed tomographic scan of the abdomen, an intravenous pyelogram, and a barium enema examination, showed no evidence of disease. She was then referred to the Surgery Branch of the National Cancer

REFERENCES

ABSTRACT | REFERENCES

Carrasquillo JA, Sugarbaker P, Colcher D, et al: Peritoneal carcinomatosis: Imaging with intraperitoneal injection of I-131-labeled B72.3 monoclonal antibody . Radiology 1988;;167:35-40.

Colcher D, Esteban J, Carrasquillo JA, et al: Complementation of intracavitary and intravenous administration of a monoclonal antibody (B72.3) in patients with carcinoma . Cancer Res 1987;;47:4218-4224.

Schlom J: Basic principles and applications of monoclonal antibodies in the management of carcinomas: The Richard and Hinda Rosenthal Foundation Award lecture . Cancer Res 1986;;46:3225-3238.

Johnston WW, Szapk CA, Thor A, et al: Applications of immunocytochemistry to clinical cytology . Cancer Invest 1987;;5:593-611.

Boyer CM, Lidor Y, Lottich SC, et al: Antigenic cell surface markers in human solid tumors . Antibody Immunoconj Radiopharm 1988;;1:105-162.

Colcher D, Hand HP, Nuti M, et al: A spectrum of monoclonal antibodies reactive with human mammary tumor cells . Proc Natl Acad Sci USA 1981;;78:3199-3203.

Johnson VG, Schlom J, Paterson AJ, et al: Analysis of a human tumor-associated glycoprotein (TAG-72) identified by a monoclonal antibody B72.3 . Cancer Res 1986;;46:850-857.

Thor A, Ohuchi N, Szpak CA, et al: The distribution of oncofetal antigen TAG-72 defined by monoclonal antibody B72.3 . Cancer Res 1986;;46:3118-3124.

Thor A, Gorstein F, Ohuchi N, et al: Tumor-associated glycoprotein (TAG-72) in ovarian carcinomas defined by monoclonal antibody B72.3 . JNCI 1986;;76:995-1006.

Colcher D, Keenan AM, Larson SM, et al: Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts . Cancer Res 1984;;44:5744-5751.

Esteban JM, Colcher D, Sugarbaker P, et al: Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb 72.3 . Int J Cancer 1987;;39:50-59.

Carrasquillo JA, Sugarbaker P, Colcher D, et al: Radioimmunoscintigraphy of colon cancer with iodine-131-labeled B72.3 monoclonal antibody . J Nucl Med 1988;;29:1022-1030.

Renda A, Salvatore M, Sava M, et al: Immunoscintigraphy in the follow-up of patients operated on for carcinoma of the sigmoid and rectum . Dis Colon Rectum 1987;;30:683-686.

Sickle-Santanello BJ, O'Dwyer PJ, Mojzisik C, et al: Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors . Dis Colon Rectum 1987;;30:761-764.

Martin EW, Mojzisik CM, Hinkle GH, et al: Radioimmunoguided surgery using monoclonal antibodies . Am J Surg 1988;;156:386-392.

Whittle N, Adair J, Lloyd C, et al: Expression in COS cells of a mouse-human chimaeric B72.3 antibody . Protein Engineering 1987;;1:499-505.

Steplewski Z, Sun LK, Shearman CW, et al: Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity . Proc Natl Acad Sci USA 1988;;85:4852-4856.

Muraro R, Kuroki M, Wunderlich D, et al: Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein-72 antigen . Cancer Res 1988;;48:4588-4596.

Ohuchi N, Simpson J, Colcher D, et al: Complementation of anti-CEA and anti-TAG-72 monoclonal antibodies in reactivity to human gastric adenocarcinomas . Int J Cancer 1987;;40:726-733.

Greiner JW, Guadagni F, Noguchi P, et al: Recombinant interferon enhances monoclonal antibody-targeting of carcinoma lesions in vivo . Science 1987;;235:895-898.

Greiner JW, Fisher PB, Pestka S, et al: Differential effects of recombinant human leukocyte interferons on cell surface antigen expression . Cancer Res 1986;;46:4984-4990.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal