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May 12, 1989, Vol 261, No. 18 >
ARTICLE | May 12, 1989

Human Papillomavirus Type 16 DNA in Periungual Squamous Cell Carcinomas FREE

Ronald L. Moy, MD; Yehuda D. Eliezri, MD; Gerard J. Nuovo, MD; John A. Zitelli, MD; Richard G. Bennett, MD; Saul Silverstein, PhD
[+] Author Affiliations

Reprint requests to the Department of Microbiology, Columbia University, 701 W 168th St, New York, NY 10032 (Dr Silverstein).


JAMA. 1989;261(18):2669-2673. doi:10.1001/jama.1989.03420180093037
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References

Ten squamous cell carcinomas (in situ or invasive) of the fingernail region were analyzed for the presence of DNA sequences homologous to human papillomavirus (HPV) by dot blot hybridization. In most patients, the lesions were verrucae of long-term duration that were refractory to conventional treatment methods. Eight of the lesions contained HPV DNA sequences, and in six of these the sequences were related to HPV 16 as deduced from low-stringency nucleic acid hybridization followed by low- and high-stringency washes. Furthermore, the restriction endonuclease digestion pattern of DNA isolated from four of these lesions was diagnostic of episomal HPV 16. The high-frequency association of HPV 16 with periungual squamous cell carcinoma is similar to that reported for HPV 16 with squamous cell carcinomas on mucous membranes at other sites, notably the genital tract. Our findings suggest that HPV 16 may play an important role in the development of squamous cell carcinomas of the finger, most notably those lesions that are chronic and located in the periungual area.

(JAMA. 1989;261:2669-2673)

REFERENCES

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Velpeaus M.  Tumeur cancereuse de la phalange ungueale de l'indicateur . Gaz Hop. 1850;;2:314-324.
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Silverman I.  Epithelioma following chronic paronychia . Am J Surg. 1959;;29:141-142.
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Campbell CJ, Klokarn T.  Squamous cell carcinoma of the nail bed in epidermal dysplasia . J Bone Joint Surg Am. 1966;;4:92-99.
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Albom MJ.  Squamous cell carcinoma of the finger and nail bed: a review of the literature and treatment by Mohs surgical technique . J Dermatol Surg Oncol. 1975;;1:43-48.
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Goette DK.  Carcinoma in situ in verruca vulgaris . Int J Dermatol. 1980;;19:98-100.
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Grussendorf EI, Gahlen W.  Metaplasia of a verruca vulgaris into spinocellular carcinoma . Dermatologica . 1975;;50:295-299.
7 +
Shelly WB, Wood MG.  Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema . Cancer. 1984;;43:820-824.
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Mikhail G.  Subungual epidermoid carcinoma . J Am Acad Dermatol. 1984;;11:291-298.
9 +
Broker TR, Botchan M.  Papillomaviruses: retrospectives and prospectives . In: Botchan M, Grodzicker T, Sharp PA, eds. Cancer Cells IV: DNA Tumor Viruses . New York, NY: Cold Spring Harbor Laboratory; 1986;:7-36
10 +
Ikenberg H, Gissman L, Gross G, Grussendorf-Conen EI, Zur-Hausen H.  Human papillomavirus type 16 related DNA in genital Bowen's disease and in bowenoid papulosis . Int J Cancer. 1983;;32:563-565.
11 +
Dehmezian RH, Batsakis JG, Goepfert H.  In situ hybridization of papillomavirus DNA in head and neck squamous cell carcinomas . Arch Otolaryngol Head Neck Surg. 1987;;113:819-821.
12 +
Stone MS, Noonan CA, Tschen J, Bruce S.  Bowen's disease of the feet: presence of human papillomavirus 16 DNA in tumor tissue . Arch Dermatol. 1987;;123:1517-1520.
13 +
DiLuca DR, Pilotti S, Stafanon B, et al.  Human papillomavirus type 16 in genital tumors: a pathological and molecular analysis . J Gen Virol. 1986;;67:583-589.
14 +
Crum CP, Mitao M, Levine RU, Silverstein SJ.  Cervical papillomaviruses segregate within morphologically distinct precancerous lesions . J Virol. 1985;;54:675-681.
15 +
Ruiter M.  On malignant degeneration of skin lesions on epidermodysplasia verruciformis . Dermatol Venereol. 1986;;49:309-314.
16 +
Ostrow RS, Bender M, Niimura M, et al.  Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis . Proc Natl Acad Sci. 1982;;79:1634-1638.
17 +
Orth G.  Epidermodysplasia verruciformis . In: Salzman NP, Howley PM, eds: The Papovaviridae . New York, NY: Plenum Press; 1987;;2:199-243.
18 +
Ostrow RS, Manias D, Mitchell AJ, Stawowy L, Faras AJ.  Epidermodysplasia verruciformis: a case study associated with primary lymphatic dysplasia, depressed cell-mediated immunity, and Bowen's disease containing human papillomavirus 16 DNA . Arch Dermatol. 1987;;123:1511-1516.
19 +
Zur Hausen H.  Human papillomavirus in human cancer . Cancer . 1987;;59:1690-1692.
20 +
Pfister H, Gassenmaier A, Nurnberger F, Stuutgen G.  Human papillomavirus 5 DNA in a carcinoma of an epidermodysplasia verruciformis patient infected with various human papilloma virus types . Cancer Res . 1983;;43:1436-1441.
21 +
Richart RM.  Causes and management of cervical intraepithelial neoplasia . Cancer . 1987;;60:1951-1959.
22 +
Feinberg AP, Vogelstein B.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity . Anal Biochem. 1983;;132:6-13.
23 +
Boshart M, Gissman L, Ikenberg H, Kleinheinz A, Scheurlen W, Zur Hausen H.  A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer . EMBOJ. 1984;;3:1151-1157.
24 +
Nuovo GJ, Crum CP, Silverstein SJ.  Papillomavirus infection of the uterine cervix . Microbiol Pathogenesis. 1987;;3:73-79.
25 +
Lorincz A, Quinn AP, Lancaster WP, Temple GF.  A new type of papillomavirus associated with cancer of the uterine cervix . Virology. 1987;; 159:187-190.
26 +
Beaudenon S, Kremsdorf D, Croissant D, Jablonska S, Wain-Hobson S, Orth G.  A novel type of human papillomavirus associated with genital neoplasias . Nature. 1986;;321:246-249.
27 +
Nuovo GJ, Crum CP, DeVilliers EM, Levine RU, Silverstein SJ.  Isolation of a novel human papillomavirus (type 51) from a cervical condyloma . J Virol. 1988;;62:1452-1455.
28 +
Shirasawa H, Tomita Y, Sekiya S, Takamizawa H, Simizu B.  Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas . J Gen Virol. 1987;;68:583-589.
29 +
Schwarz E, Freese UK, Gissman L, et al.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells . Nature . 1985;;314:111-114
30 +
Tsunokawa Y, Takebe N, Nozowa S, et al.  Presence of human papillomavirus type-16 and type-18 DNA sequences and their expression in cervical cancers and cell lines from Japanese patients . Int J Cancer . 1986;;37:499-503.
31 +
Crum CP, Nuovo G, Friedman D, Silverstein SJ.  Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers . J Virol. 1988;;62:84-90.
32 +
Yutsodo M, Okamoto Y, Hakura A.  Functional dissociation of transforming genes of human papillomavirus type 16 . Virology . 1988;;163:594-597.
33 +
Lehn H, Villa LL, Marziona F, Hilgarth M, Hillemans HG, Sauer G.  Physical state and biological activity of human papillomavirus genomes in precancerous lesions of the female genital tract . J Gen Virol. 1988;;69:187-196.
34 +
Lorincz AT, Temple GF, Kurman RJ, Jenson AB, Lancaster WD.  Oncogenic association of specific human papillomavirus types with cervical neoplasia . JNCI. 1988;;79:671-677.

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1 +
Velpeaus M.  Tumeur cancereuse de la phalange ungueale de l'indicateur . Gaz Hop. 1850;;2:314-324.
2 +
Silverman I.  Epithelioma following chronic paronychia . Am J Surg. 1959;;29:141-142.
3 +
Campbell CJ, Klokarn T.  Squamous cell carcinoma of the nail bed in epidermal dysplasia . J Bone Joint Surg Am. 1966;;4:92-99.
4 +
Albom MJ.  Squamous cell carcinoma of the finger and nail bed: a review of the literature and treatment by Mohs surgical technique . J Dermatol Surg Oncol. 1975;;1:43-48.
5 +
Goette DK.  Carcinoma in situ in verruca vulgaris . Int J Dermatol. 1980;;19:98-100.
6 +
Grussendorf EI, Gahlen W.  Metaplasia of a verruca vulgaris into spinocellular carcinoma . Dermatologica . 1975;;50:295-299.
7 +
Shelly WB, Wood MG.  Transformation of the common wart into squamous cell carcinoma in a patient with primary lymphedema . Cancer. 1984;;43:820-824.
8 +
Mikhail G.  Subungual epidermoid carcinoma . J Am Acad Dermatol. 1984;;11:291-298.
9 +
Broker TR, Botchan M.  Papillomaviruses: retrospectives and prospectives . In: Botchan M, Grodzicker T, Sharp PA, eds. Cancer Cells IV: DNA Tumor Viruses . New York, NY: Cold Spring Harbor Laboratory; 1986;:7-36
10 +
Ikenberg H, Gissman L, Gross G, Grussendorf-Conen EI, Zur-Hausen H.  Human papillomavirus type 16 related DNA in genital Bowen's disease and in bowenoid papulosis . Int J Cancer. 1983;;32:563-565.
11 +
Dehmezian RH, Batsakis JG, Goepfert H.  In situ hybridization of papillomavirus DNA in head and neck squamous cell carcinomas . Arch Otolaryngol Head Neck Surg. 1987;;113:819-821.
12 +
Stone MS, Noonan CA, Tschen J, Bruce S.  Bowen's disease of the feet: presence of human papillomavirus 16 DNA in tumor tissue . Arch Dermatol. 1987;;123:1517-1520.
13 +
DiLuca DR, Pilotti S, Stafanon B, et al.  Human papillomavirus type 16 in genital tumors: a pathological and molecular analysis . J Gen Virol. 1986;;67:583-589.
14 +
Crum CP, Mitao M, Levine RU, Silverstein SJ.  Cervical papillomaviruses segregate within morphologically distinct precancerous lesions . J Virol. 1985;;54:675-681.
15 +
Ruiter M.  On malignant degeneration of skin lesions on epidermodysplasia verruciformis . Dermatol Venereol. 1986;;49:309-314.
16 +
Ostrow RS, Bender M, Niimura M, et al.  Human papillomavirus DNA in cutaneous primary and metastasized squamous cell carcinomas from patients with epidermodysplasia verruciformis . Proc Natl Acad Sci. 1982;;79:1634-1638.
17 +
Orth G.  Epidermodysplasia verruciformis . In: Salzman NP, Howley PM, eds: The Papovaviridae . New York, NY: Plenum Press; 1987;;2:199-243.
18 +
Ostrow RS, Manias D, Mitchell AJ, Stawowy L, Faras AJ.  Epidermodysplasia verruciformis: a case study associated with primary lymphatic dysplasia, depressed cell-mediated immunity, and Bowen's disease containing human papillomavirus 16 DNA . Arch Dermatol. 1987;;123:1511-1516.
19 +
Zur Hausen H.  Human papillomavirus in human cancer . Cancer . 1987;;59:1690-1692.
20 +
Pfister H, Gassenmaier A, Nurnberger F, Stuutgen G.  Human papillomavirus 5 DNA in a carcinoma of an epidermodysplasia verruciformis patient infected with various human papilloma virus types . Cancer Res . 1983;;43:1436-1441.
21 +
Richart RM.  Causes and management of cervical intraepithelial neoplasia . Cancer . 1987;;60:1951-1959.
22 +
Feinberg AP, Vogelstein B.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity . Anal Biochem. 1983;;132:6-13.
23 +
Boshart M, Gissman L, Ikenberg H, Kleinheinz A, Scheurlen W, Zur Hausen H.  A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer . EMBOJ. 1984;;3:1151-1157.
24 +
Nuovo GJ, Crum CP, Silverstein SJ.  Papillomavirus infection of the uterine cervix . Microbiol Pathogenesis. 1987;;3:73-79.
25 +
Lorincz A, Quinn AP, Lancaster WP, Temple GF.  A new type of papillomavirus associated with cancer of the uterine cervix . Virology. 1987;; 159:187-190.
26 +
Beaudenon S, Kremsdorf D, Croissant D, Jablonska S, Wain-Hobson S, Orth G.  A novel type of human papillomavirus associated with genital neoplasias . Nature. 1986;;321:246-249.
27 +
Nuovo GJ, Crum CP, DeVilliers EM, Levine RU, Silverstein SJ.  Isolation of a novel human papillomavirus (type 51) from a cervical condyloma . J Virol. 1988;;62:1452-1455.
28 +
Shirasawa H, Tomita Y, Sekiya S, Takamizawa H, Simizu B.  Integration and transcription of human papillomavirus type 16 and 18 sequences in cell lines derived from cervical carcinomas . J Gen Virol. 1987;;68:583-589.
29 +
Schwarz E, Freese UK, Gissman L, et al.  Structure and transcription of human papillomavirus sequences in cervical carcinoma cells . Nature . 1985;;314:111-114
30 +
Tsunokawa Y, Takebe N, Nozowa S, et al.  Presence of human papillomavirus type-16 and type-18 DNA sequences and their expression in cervical cancers and cell lines from Japanese patients . Int J Cancer . 1986;;37:499-503.
31 +
Crum CP, Nuovo G, Friedman D, Silverstein SJ.  Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers . J Virol. 1988;;62:84-90.
32 +
Yutsodo M, Okamoto Y, Hakura A.  Functional dissociation of transforming genes of human papillomavirus type 16 . Virology . 1988;;163:594-597.
33 +
Lehn H, Villa LL, Marziona F, Hilgarth M, Hillemans HG, Sauer G.  Physical state and biological activity of human papillomavirus genomes in precancerous lesions of the female genital tract . J Gen Virol. 1988;;69:187-196.
34 +
Lorincz AT, Temple GF, Kurman RJ, Jenson AB, Lancaster WD.  Oncogenic association of specific human papillomavirus types with cervical neoplasia . JNCI. 1988;;79:671-677.

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