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Toddler Eats Clonidine Patch and Nearly Quits Smoking for Life FREE

Howard M. Corneli, MD; William W. Banner, MD; Donald D. Vernon, MD; Paul H. Swenson, MD
JAMA. 1989;261(1):42-42. doi:10.1001/jama.1989.03420010052017
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To the Editor.—  Clonidine has recently been advocated as an aid in smoking cessation.1,2 Should it prove useful, it is likely that childhood ingestions of clonidine, already common, would increase. We recently treated a child with a toxic reaction due to ingestion of clonidine from a transdermal patch prescribed for smoking cessation.

Report of a Case. —  A 2-year-old child presented to the emergency department with a history of progressive lethargy over several hours. Examination revealed a heart rate of 75 beats per minute, blood pressure of 90/50 mm Hg, 2-mm pupils, and gasping respirations. The child responded to pain only by withdrawal; she did not open her eyes or speak. Her parents denied exposure to prescription medicines or heart medicines and, when asked specifically, denied exposure to clonidine.Routine urine toxicology screens by chromatography were negative on two samples taken within five hours of ingestion. The child was

REFERENCES

Glassman AH, Jackson WK, Walsh BT, et al:  Cigarette craving, smoking withdrawal, and clonidine . Science 1984;;226:864-866.
Glassman AH, Stetner F, Walsh BT, et al:  Heavy smokers, smoking cessation, and clonidine . JAMA 1988;;259:2863-2866.
Caravati EM, Bennett DL:  Clonidine transdermal patch poisoning . Ann Emerg Med 1988;;17:175-176.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Glassman AH, Jackson WK, Walsh BT, et al:  Cigarette craving, smoking withdrawal, and clonidine . Science 1984;;226:864-866.
Glassman AH, Stetner F, Walsh BT, et al:  Heavy smokers, smoking cessation, and clonidine . JAMA 1988;;259:2863-2866.
Caravati EM, Bennett DL:  Clonidine transdermal patch poisoning . Ann Emerg Med 1988;;17:175-176.
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To understand the clinical management of acute heart failure syndromes.
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