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Fraudulent Studies and Meta-analysis-Reply FREE

Stephen B. Thacker, MD
JAMA. 1988;260(6):792-792. doi:10.1001/jama.1988.03410060061026
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In Reply.—  Dishonesty does undermine the basis of research and the methods used to ensure the quality of science. Breaches of integrity not only can be self-serving for individuals such as John Darsee and Robert Slutsky, but also may waste funds, impact on the careers of others, and create unnecessary replicative studies.1,2 Fraudulent studies, such as that of Stephen Breuning, can impact directly on treatment practoces.3Meta-analysis, when properly conducted, can serve as a deterrent to the impact of fraud. Although creative fraud can escape detection of peer reviewers, a systematic overview of a field of research is designed to detect inconsistency not only within the work of a single investigator but also among authors. The meta-analyst then searches for explanations of these inconsistencies. Only consistent findings will then be combined to estimate effect. Indeed, it was careful review by a single reviewer of two articles by Slutsky

REFERENCES

Engler RL, Covell JW, Friedman PJ, et al:  Misrepresentation and responsibility in medical research . N Engl J Med 1987;;317:1383-1389.
Relman AS:  Lessons from the Darsee affair . N Engl J Med 1983;;308:1415-1417.
Holden C:  NIMH finds a case of 'serious misconduct.' Science 1987;;235:1566-1567.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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Engler RL, Covell JW, Friedman PJ, et al:  Misrepresentation and responsibility in medical research . N Engl J Med 1987;;317:1383-1389.
Relman AS:  Lessons from the Darsee affair . N Engl J Med 1983;;308:1415-1417.
Holden C:  NIMH finds a case of 'serious misconduct.' Science 1987;;235:1566-1567.
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To understand the clinical management of acute heart failure syndromes.
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