To the Editor.— In the treatment of chronic congestive heart failure, Mulrow et al1 concluded that all vasodilators except hydralazine hydrochloride were associated with improved functional status. However, "feeling better" usually occurred early and was not sustained. Moreover, combined therapy with nitrates and hydralazine offered no protective benefit, and therapy with nitrates alone was associated with a trend to increased (sic) mortality. In studies evaluating α-antagonists, the longest trial (six months) found no significant functional improvement either early or late. In those given angiotensin converting enzyme inhibitors, a significant protective effect was found but individuals who profited most could not be identified. Moreover, questions were raised in the minds of the authors about causality of any benefit of angiotensin converting enzyme inhibitors because control groups were not balanced according to amount of diuretics employed. Finally, this study is a metaanalysis, without contact with a single patient and based only
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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