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September 16, 1988, Vol 260, No. 11 >
ARTICLE | September 16, 1988

Acyclovir Prevents Reactivation of Herpes Simplex Labialis in Skiers FREE

Spotswood L. Spruance, MD; Mary Lou Hamill, PharmD; William S. Hoge, RPh; L. Gray Davis, MS; John Mills, MD
[+] Author Affiliations

Reprint requests to Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132 (Dr Spruance).


JAMA. 1988;260(11):1597-1599. doi:10.1001/jama.1988.03410110105036
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References

To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.

(JAMA 1988;260:1597-1599)

REFERENCES

1 +
Mills J, Hauer L, Gottlieb A, et al:  Recurrent herpes labialis in skiers: Clinical observations and the effect of sunscreen . Am J Sports Med 1987;;15:76-77.
2 +
Spruance SL:  Pathogenesis of herpes simplex labialis: Excretion of virus in the oral cavity . J Clin Microbiol 1984;;19:675-679.
3 +
Young SK, Rowe NH, Buchanan RA:  A clinical study of the control of facial mucocutaneous herpes virus infections: I. Characterization of natural history in a professional school population . Oral Surg Oral Med Oral Pathol 1976;;41:498-507.
4 +
Wheeler CE Jr:  Pathogenesis of recurrent herpes simplex infections . J Invest Dermatol 1975;;65:341-346.
5 +
Spruance SL:  Pathogenesis of herpes simplex labialis: Experimental induction of lesions with UV light . J Clin Microbiol 1985;;22:366-368.
6 +
Perna JJ, Mannix ML, Rooney JF, et al:  Reactivation of latent herpes simplex virus infection by ultraviolet light: A human model . J Am Acad Dermatol 1987;;17:473-478.
7 +
Straus SE, Takiff HE, Seidlin M, et al:  Suppression of frequently recurring genital herpes: A placebo-controlled double-blind trial of oral acyclovir . N Engl J Med 1984;;310:1545-1550.
8 +
Douglas JM, Critchlow C, Benedetti J, et al:  Double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection . N Engl J Med 1984;;310:1551-1556.
9 +
Green JA, Spruance SL, Wenerstrom G, et al:  Post-herpetic erythema multiforme prevented with prophylactic oral acyclovir . Ann Intern Med 1985;;102:632-633.
10 +
Lemak MA, Duvic M, Bean SF:  Oral acyclovir for the prevention of herpes-associated erythema multiforme . J Am Acad Dermatol 1986;;15:50-54.
11 +
Laskin OL:  Acyclovir and suppression of frequently recurring herpetic whitlow . Ann Intern Med 1985;;102:494-495.
12 +
Saral R, Burns WH, Laskin OL, et al:  Acyclovir prophylaxis of herpes simplex virus infections . N Engl J Med 1981;;305:63-67.
13 +
Strauss SE, Seidlin M, Takiff H, et al:  Oral acyclovir to suppress recurring herpes simplex virus infections in immunodeficient patients . Ann Intern Med 1984;;100:522-524.
14 +
Raborn GW, McGaw WT, Grace M, et al:  Oral acyclovir and herpes labialis: A randomized, double-blind, placebo-controlled study . J Am Dent Assoc 1987;;115:38-42.
15 +
Spruance SL, Rowe N, Stewart J, et al:  Treatment of herpes simplex labialis with oral acyclovir, abstract 623 . Program and abstracts of the 26th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Sept 28 to Oct 1, 1986.
16 +
Spruance SL, McKeough MB, Wenerstrom G:  Prophylactic therapy with oral acyclovir for experimental ultraviolet light-induced herpes simplex labialis , abstracted. Antiviral Res 1988;;9:121.
17 +
Lundeen RC, Langlais RP, Terezhalmy GT:  Sunscreen protection for lip mucosa: A review and update . JAm Dent Assoc 1985;;111:617-621.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Mills J, Hauer L, Gottlieb A, et al:  Recurrent herpes labialis in skiers: Clinical observations and the effect of sunscreen . Am J Sports Med 1987;;15:76-77.
2 +
Spruance SL:  Pathogenesis of herpes simplex labialis: Excretion of virus in the oral cavity . J Clin Microbiol 1984;;19:675-679.
3 +
Young SK, Rowe NH, Buchanan RA:  A clinical study of the control of facial mucocutaneous herpes virus infections: I. Characterization of natural history in a professional school population . Oral Surg Oral Med Oral Pathol 1976;;41:498-507.
4 +
Wheeler CE Jr:  Pathogenesis of recurrent herpes simplex infections . J Invest Dermatol 1975;;65:341-346.
5 +
Spruance SL:  Pathogenesis of herpes simplex labialis: Experimental induction of lesions with UV light . J Clin Microbiol 1985;;22:366-368.
6 +
Perna JJ, Mannix ML, Rooney JF, et al:  Reactivation of latent herpes simplex virus infection by ultraviolet light: A human model . J Am Acad Dermatol 1987;;17:473-478.
7 +
Straus SE, Takiff HE, Seidlin M, et al:  Suppression of frequently recurring genital herpes: A placebo-controlled double-blind trial of oral acyclovir . N Engl J Med 1984;;310:1545-1550.
8 +
Douglas JM, Critchlow C, Benedetti J, et al:  Double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection . N Engl J Med 1984;;310:1551-1556.
9 +
Green JA, Spruance SL, Wenerstrom G, et al:  Post-herpetic erythema multiforme prevented with prophylactic oral acyclovir . Ann Intern Med 1985;;102:632-633.
10 +
Lemak MA, Duvic M, Bean SF:  Oral acyclovir for the prevention of herpes-associated erythema multiforme . J Am Acad Dermatol 1986;;15:50-54.
11 +
Laskin OL:  Acyclovir and suppression of frequently recurring herpetic whitlow . Ann Intern Med 1985;;102:494-495.
12 +
Saral R, Burns WH, Laskin OL, et al:  Acyclovir prophylaxis of herpes simplex virus infections . N Engl J Med 1981;;305:63-67.
13 +
Strauss SE, Seidlin M, Takiff H, et al:  Oral acyclovir to suppress recurring herpes simplex virus infections in immunodeficient patients . Ann Intern Med 1984;;100:522-524.
14 +
Raborn GW, McGaw WT, Grace M, et al:  Oral acyclovir and herpes labialis: A randomized, double-blind, placebo-controlled study . J Am Dent Assoc 1987;;115:38-42.
15 +
Spruance SL, Rowe N, Stewart J, et al:  Treatment of herpes simplex labialis with oral acyclovir, abstract 623 . Program and abstracts of the 26th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Sept 28 to Oct 1, 1986.
16 +
Spruance SL, McKeough MB, Wenerstrom G:  Prophylactic therapy with oral acyclovir for experimental ultraviolet light-induced herpes simplex labialis , abstracted. Antiviral Res 1988;;9:121.
17 +
Lundeen RC, Langlais RP, Terezhalmy GT:  Sunscreen protection for lip mucosa: A review and update . JAm Dent Assoc 1985;;111:617-621.

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