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May 20, 1988, Vol 259, No. 19 >
ARTICLE | May 20, 1988

Oral Acyclovir for Treatment of First-Episode Herpes Simplex Virus Proctitis FREE

Ann M. Rompalo, MD; Gregory J. Mertz, MD; L. Gray Davis, MS; Jacqueline Benedetti, PhD; Cathy Critchlow, MS; Walter E. Stamm, MD; Lawrence Corey, MD
[+] Author Affiliations

Reprints not available.


JAMA. 1988;259(19):2879-2881. doi:10.1001/jama.1988.03720190047030
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References

Twenty-nine patients with first-episode rectal herpes simplex virus infection were enrolled in a double-blind trial of oral acyclovir, 400 mg five times daily, vs placebo treatment. Eighty percent of those receiving acyclovir compared with 25% of placebo recipients no longer had herpes simplex virus isolated from their rectal lesions three days after onset of therapy. The median duration of rectal lesions and viral excretion from rectal lesions (median, five and zero days, respectively) was significantly shorter in patients treated with acyclovir than in placebo-treated patients (14 and 11 days, respectively). Durations of local signs and symptoms of proctitis, such as rectal pain, discharge, and friability, were shorter in acyclovir recipients than in placebo recipients, but these differences were not statistically significant. Daily administration of 2 g of oral acyclovir for ten days alleviates some of the clinical signs of herpes simplex virus rectal infection.

(JAMA 1988;259:2879-2881)

REFERENCES

1 +
Quinn TC, Stamm WE, Goodell SE, et al:  The polymicrobial origin of intestinal infections in homosexual men. N Engl J Med 1983;;309:575-582.
2 +
Goodell SE, Quinn TC, Mrktichian E, et al:  Herpes simplex virus proctitis in homosexual men. N Engl J Med 1983;;308:868-871.
3 +
Goldmeir D:  Urinary retention and intestinal obstruction associated with anorectal herpes simplex virus infection. Br Med J 1975;;2:425.
4 +
Samarasinghe PL, Oates JK, MacLennan IPB:  Herpetic proctitis and sacral radiomyelopathy: A hazard for homosexual men. Br Med J 1979;;2:365-366.
5 +
Wade JC, Newton B, Flournoy N, et al:  Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med 1984;;100:823-828.
6 +
Bryson YJ, Dillon M, Lovett M, et al:  Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. N Engl J Med 1983;;308:916-922.
7 +
Douglas JM, Critchlow C, Benedetti J, et al:  A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med 1984;;310:1551-1556.
8 +
Mertz GJ, Critchlow CW, Benedetti J, et al:  Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. JAMA 1984;;252:1147-1151.
9 +
Corey L, Fife KH, Benedetti JK, et al:  Intravenous acyclovir for the treatment of primary genital herpes. Ann Intern Med 1983;;98:914-921.
10 +
Morello JA, Janda WM, Bohnhoff M:  Neisseria and Branhamella , in Lenette EH, Balows A, Hausler WJ Jr, et al (eds): Manual of Clinical Microbiology , ed 4. Washington, DC, American Public Health Association, 1985;, pp 176-178.
11 +
Stamm WE, Tam MR, Koester M, et al:  Detection of Chlamydia trachomatis inclusions in McCoy cell cultures with fluorescein-conjugated monoclonal antibodies. J Clin Microbiol 1983;;17:666-668.
12 +
Kelly MT, Brenner DJ, Farmer JJ:  Enterobacteriaceae , in Lenette Eh, Balows A, Hausler WJ Jr, et al (eds): Manual of Clinical Microbiology , ed 4. Washington, DC, American Public Health Association, 1985;, pp 264-265.
13 +
Melvin DM, Brooke MM: Laboratory Procedures for the Diagnosis of Intestinal Parasites . Atlanta, US Dept of Health and Human Services, 1980;.
14 +
Goldstein LC, Corey L, McDougall J, et al:  Monoclonal antibodies to herpes simplex virus: Use in antigenic typing and rapid diagnosis. J Infect Dis 1983;;147:829-837.
15 +
Stadler H, Oxman MN, Herrmann KL:  Herpes simplex virus microneutralization: A simplification of the test. J Infect Dis 1975;;131:423-430.
16 +
Reichman RC, Badger GJ, Mertz GJ, et al:  Treatment of recurrent herpes simplex infections with oral acyclovir: A controlled trial. JAMA 1984;;251:2103-2108.
17 +
Corey L, Nahmias AJ, Guinan ME, et al:  A trial of topical acyclovir in genital herpes simplex infections. N Engl J Med 1982;;306:1313-1319.
18 +
McKendrick MW, McGill JI, White JE, et al:  Oral acyclovir for acute herpes zoster. Br Med J 1986;;293:1529-1532.

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1 +
Quinn TC, Stamm WE, Goodell SE, et al:  The polymicrobial origin of intestinal infections in homosexual men. N Engl J Med 1983;;309:575-582.
2 +
Goodell SE, Quinn TC, Mrktichian E, et al:  Herpes simplex virus proctitis in homosexual men. N Engl J Med 1983;;308:868-871.
3 +
Goldmeir D:  Urinary retention and intestinal obstruction associated with anorectal herpes simplex virus infection. Br Med J 1975;;2:425.
4 +
Samarasinghe PL, Oates JK, MacLennan IPB:  Herpetic proctitis and sacral radiomyelopathy: A hazard for homosexual men. Br Med J 1979;;2:365-366.
5 +
Wade JC, Newton B, Flournoy N, et al:  Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med 1984;;100:823-828.
6 +
Bryson YJ, Dillon M, Lovett M, et al:  Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. N Engl J Med 1983;;308:916-922.
7 +
Douglas JM, Critchlow C, Benedetti J, et al:  A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med 1984;;310:1551-1556.
8 +
Mertz GJ, Critchlow CW, Benedetti J, et al:  Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection. JAMA 1984;;252:1147-1151.
9 +
Corey L, Fife KH, Benedetti JK, et al:  Intravenous acyclovir for the treatment of primary genital herpes. Ann Intern Med 1983;;98:914-921.
10 +
Morello JA, Janda WM, Bohnhoff M:  Neisseria and Branhamella , in Lenette EH, Balows A, Hausler WJ Jr, et al (eds): Manual of Clinical Microbiology , ed 4. Washington, DC, American Public Health Association, 1985;, pp 176-178.
11 +
Stamm WE, Tam MR, Koester M, et al:  Detection of Chlamydia trachomatis inclusions in McCoy cell cultures with fluorescein-conjugated monoclonal antibodies. J Clin Microbiol 1983;;17:666-668.
12 +
Kelly MT, Brenner DJ, Farmer JJ:  Enterobacteriaceae , in Lenette Eh, Balows A, Hausler WJ Jr, et al (eds): Manual of Clinical Microbiology , ed 4. Washington, DC, American Public Health Association, 1985;, pp 264-265.
13 +
Melvin DM, Brooke MM: Laboratory Procedures for the Diagnosis of Intestinal Parasites . Atlanta, US Dept of Health and Human Services, 1980;.
14 +
Goldstein LC, Corey L, McDougall J, et al:  Monoclonal antibodies to herpes simplex virus: Use in antigenic typing and rapid diagnosis. J Infect Dis 1983;;147:829-837.
15 +
Stadler H, Oxman MN, Herrmann KL:  Herpes simplex virus microneutralization: A simplification of the test. J Infect Dis 1975;;131:423-430.
16 +
Reichman RC, Badger GJ, Mertz GJ, et al:  Treatment of recurrent herpes simplex infections with oral acyclovir: A controlled trial. JAMA 1984;;251:2103-2108.
17 +
Corey L, Nahmias AJ, Guinan ME, et al:  A trial of topical acyclovir in genital herpes simplex infections. N Engl J Med 1982;;306:1313-1319.
18 +
McKendrick MW, McGill JI, White JE, et al:  Oral acyclovir for acute herpes zoster. Br Med J 1986;;293:1529-1532.

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