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Experience With Single-Lung Transplantation for Pulmonary Fibrosis FREE

Joel D. Cooper, MD; Bernard S. Goldman, MD; Melvyn Goldberg, MD; Robert J. Ginsberg, MD; F. Griffith Pearson, MD; G. Alexander Patterson, MD; Hugh E. Scully, MD; Thomas R. J. Todd, MD; Paul Waters, MD; Ronald Grossman, MD; Janet Maurer, MD; Phillip Halloran, MD; Wilfred DeMajo, MD; Vite Zulys, MD; Michael F. X. Glynn, MD; Hiller Vellend, MD; Cheryl Dear, BSc; Anne Kuus, BSc; Barbara Dorian, MD; Donna Tweedell, RN
[+] Author Affiliations

Reprint requests to Toronto General Hospital, Division of Thoracic Surgery, Eaton Bldg 10-226, Toronto, Ontario, Canada M5G 1L7 (Dr Cooper).


JAMA. 1988;259(15):2258-2262. doi:10.1001/jama.1988.03720150034032
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Repeated success has now been obtained with single-lung transplantation for end-stage pulmonary fibrosis. Potential candidates for this procedure are individuals who are less than 60 years of age and who have progressive pulmonary deterioration with limited life expectancy. Since November 1983, eleven such transplantations have been performed; nine patients achieved discharge from the hospital and eight patients have remained alive up to 44 months after surgery. All of these recipients have good oxygenation on room air and good exercise tolerance and are capable of performing routine activities, including a return to previous employment. From our experience, it appears likely that single-lung transplantation can achieve the same success rates as other major organ transplantations.

(JAMA 1988;259:2258-2262)

REFERENCES

The Toronto Lung Transplant Group:  Lung transplantation for pulmonary fibrosis. N Engl J Med 1986;;314:1140-1145.
Haverich A, Scott WC, Jamieson SW:  Twenty years of lung preservation—a review. Heart Transplant 1985;;4:234-240.
Cooper JD, Pearson FG, Patterson GA, et al:  Technique of successful lung transplantation in humans. J Thorac Cardiovasc Surg 1987;;93:172-181.
Veith FJ, Koerner SK, Siegelman SS, et al:  Single lung transplantation in experimental and human emphysema. Ann Surg 1973;;178:463-476.
Griffith BP, Hardesty RL, Trento A, et al:  Heart-lung transplantation: Lessons learned and future hopes. Ann Thorac Surg 1987;;43:6-16.

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The Toronto Lung Transplant Group:  Lung transplantation for pulmonary fibrosis. N Engl J Med 1986;;314:1140-1145.
Haverich A, Scott WC, Jamieson SW:  Twenty years of lung preservation—a review. Heart Transplant 1985;;4:234-240.
Cooper JD, Pearson FG, Patterson GA, et al:  Technique of successful lung transplantation in humans. J Thorac Cardiovasc Surg 1987;;93:172-181.
Veith FJ, Koerner SK, Siegelman SS, et al:  Single lung transplantation in experimental and human emphysema. Ann Surg 1973;;178:463-476.
Griffith BP, Hardesty RL, Trento A, et al:  Heart-lung transplantation: Lessons learned and future hopes. Ann Thorac Surg 1987;;43:6-16.
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