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April 15, 1988, Vol 259, No. 15 >
ARTICLE | April 15, 1988

Adult T-Cell Leukemia/Lymphoma in Brooklyn FREE

Harvey Dosik, MD; Srdjan Denic, MD; Nainesh Patel, MD; Muthuswamy Krishnamurthy, MD; Paul H. Levine, MD; Jeffrey W. Clark, MD
[+] Author Affiliations

Presented in part at the American Society of Hematology Meetings, December 1985 (New Orleans) and December 1986 (San Francisco).

Reprints to Department of Medicine, Interfaith Medical Center, 555 Prospect PI, Brooklyn, NY 11238 (Dr Dosik).


JAMA. 1988;259(15):2255-2257. doi:10.1001/jama.1988.03720150031031
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References

Fifteen patients with adult T-cell leukemia/lymphoma (ATLL) were identified in less than a two-year period in the Crown Heights—Bedford Stuyvesant section of Brooklyn, NY. All patients were black; nine patients originated from the Caribbean islands and six from the southern United States. Two of the patients were father and daughter, the first evidence of familial occurrence in the United States. Their clinical course was similar to that of previously described patients with this disorder. To our knowledge, these 15 patients represent the largest series of ATLL reported in the United States. We recommend that ATLL be seriously considered in the differential diagnosis of patients with non- Hodgkin's lymphoma, mycosis fungoides, lymphatic leukemia, or hypercalcemia.

(JAMA 1988;259:2255-2257)

REFERENCES

1 +
Hattori T, Uchiyama T, Toibana T, et al:  Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 1981;;58:645-647.
2 +
Poiesz BJ, Ruscetti FW, Gazdar AF, et al:  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980;;77:7415-7419.
3 +
Poiesz BJ, Ruscetti FW, Reitz MS, et al:  Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia. Nature 1981;;294:268-271.
4 +
Yoshida M, Miyoshi I, Hinuma Y:  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 1982;;79:2031-2035.
5 +
Hinuma Y, Nagata K, Hanaoka M, et al:  Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981;;78:6476-6480.
6 +
Blattner WA, Kalyanaraman VS, Robert-Guroff M, et al:  The human type C retrovirus, HTLV, in blacks from the Caribbean, and relationship to adult T-cell leukemia/lymphoma. Int J Cancer 1982;;30:257-264.
7 +
Robert-Guroff M, Schupbach J, Blayney DW, et al:  Seroepidemiologic studies on human T-cell leukemia/lymphoma virus, type I: Human T-cell leukemia/lymphoma viruses. Cold Spring Harbor Symp Quant Biol , 1984;, pp 285-295.
8 +
Blattner WA, Clark JW, Gibbs WN, et al:  Human T-cell leukemia/lymphoma virus: Epidemiology and relationship to human malignancy: Human T-cell leukemia/lymphoma viruses. Cold Spring Harbor Symp Quant Biol , 1984;, pp 267-274.
9 +
Bunn PA Jr, Schechter GP, Jaffe E, et al:  Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. N Engl J Med 1983;;309:257-264.
10 +
Blayney DW, Blattner WA, Robert-Guroff M, et al:  The human T-cell leukemia/lymphoma virus (HTLV) in the southeastern United States. JAMA 1983;;250:1048-1057.
11 +
Weinberg JB, Blazey DL, Matthews TJ, et al:  Adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type I (HTLV-I) infection—North Carolina. MMWR 1987;;36:804-812.
12 +
Saxinger W, Gallo RC:  Methods in laboratory investigation: Application of the indirect enzymelinked immunosorbent assay microtest to the detection and surveillance of human T-cell leukemia/lymphoma virus. Lab Invest 1983;;49:371-377.
13 +
Saxinger W, Blattner WA, Levine PH, et al:  Human T-cell leukemia virus (HTLV-I) antibodies in Africa. Science 1984;;225:1473-1476.
14 +
The T- and B-Cell Malignancy Study Group:  Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/ lymphoma: A report of the second nationwide study of Japan. J pn J Clin Oncol 1985;;15:517-535.
15 +
Denic S, Abramson J, Anandakrishnan R, et al:  The first report of familial adult T-cell leukemia/ lymphoma in the United States. Am J Hematol , in press.
16 +
Ichimaru M, Kinoshita K, Kamihira S, et al:  Familial disposition of adult T-cell leukemia and lymphoma. GANN Monogr Cancer Res 1982;;28: 185-193.
17 +
Takatsuki K, Yamaguchi K, Kawano F, et al:  Clinical diversity in adult T-cell leukemia/lymphoma. Cancer Res 1985;;45:4644-4645.
18 +
Stam L, Dosik H, Levine P:  Human T-cell leukemia virus (HTLV-I) seropositivity in patients with renal failure. Am Soc Artif Intern Organs 1986;;15:73.
19 +
Robert-Guroff M, Weiss SH, Giron JA, et al:  Prevalence of antibodies to HTLV-I, -II and -III in intravenous drug abusers from an AIDS endemic region. JAMA 1986;;255:3133-3137.
20 +
Weis SH, Saxinger WC, Ginzburg HM, et al:  Human T-cell lymphotropic virus type I (HLTV-I) and HIV prevalence among US drug abusers (DA). Proc Am Soc Clin Oncol 1987;;6:4.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Hattori T, Uchiyama T, Toibana T, et al:  Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 1981;;58:645-647.
2 +
Poiesz BJ, Ruscetti FW, Gazdar AF, et al:  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 1980;;77:7415-7419.
3 +
Poiesz BJ, Ruscetti FW, Reitz MS, et al:  Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sezary T-cell leukemia. Nature 1981;;294:268-271.
4 +
Yoshida M, Miyoshi I, Hinuma Y:  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 1982;;79:2031-2035.
5 +
Hinuma Y, Nagata K, Hanaoka M, et al:  Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981;;78:6476-6480.
6 +
Blattner WA, Kalyanaraman VS, Robert-Guroff M, et al:  The human type C retrovirus, HTLV, in blacks from the Caribbean, and relationship to adult T-cell leukemia/lymphoma. Int J Cancer 1982;;30:257-264.
7 +
Robert-Guroff M, Schupbach J, Blayney DW, et al:  Seroepidemiologic studies on human T-cell leukemia/lymphoma virus, type I: Human T-cell leukemia/lymphoma viruses. Cold Spring Harbor Symp Quant Biol , 1984;, pp 285-295.
8 +
Blattner WA, Clark JW, Gibbs WN, et al:  Human T-cell leukemia/lymphoma virus: Epidemiology and relationship to human malignancy: Human T-cell leukemia/lymphoma viruses. Cold Spring Harbor Symp Quant Biol , 1984;, pp 267-274.
9 +
Bunn PA Jr, Schechter GP, Jaffe E, et al:  Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. N Engl J Med 1983;;309:257-264.
10 +
Blayney DW, Blattner WA, Robert-Guroff M, et al:  The human T-cell leukemia/lymphoma virus (HTLV) in the southeastern United States. JAMA 1983;;250:1048-1057.
11 +
Weinberg JB, Blazey DL, Matthews TJ, et al:  Adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type I (HTLV-I) infection—North Carolina. MMWR 1987;;36:804-812.
12 +
Saxinger W, Gallo RC:  Methods in laboratory investigation: Application of the indirect enzymelinked immunosorbent assay microtest to the detection and surveillance of human T-cell leukemia/lymphoma virus. Lab Invest 1983;;49:371-377.
13 +
Saxinger W, Blattner WA, Levine PH, et al:  Human T-cell leukemia virus (HTLV-I) antibodies in Africa. Science 1984;;225:1473-1476.
14 +
The T- and B-Cell Malignancy Study Group:  Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia/ lymphoma: A report of the second nationwide study of Japan. J pn J Clin Oncol 1985;;15:517-535.
15 +
Denic S, Abramson J, Anandakrishnan R, et al:  The first report of familial adult T-cell leukemia/ lymphoma in the United States. Am J Hematol , in press.
16 +
Ichimaru M, Kinoshita K, Kamihira S, et al:  Familial disposition of adult T-cell leukemia and lymphoma. GANN Monogr Cancer Res 1982;;28: 185-193.
17 +
Takatsuki K, Yamaguchi K, Kawano F, et al:  Clinical diversity in adult T-cell leukemia/lymphoma. Cancer Res 1985;;45:4644-4645.
18 +
Stam L, Dosik H, Levine P:  Human T-cell leukemia virus (HTLV-I) seropositivity in patients with renal failure. Am Soc Artif Intern Organs 1986;;15:73.
19 +
Robert-Guroff M, Weiss SH, Giron JA, et al:  Prevalence of antibodies to HTLV-I, -II and -III in intravenous drug abusers from an AIDS endemic region. JAMA 1986;;255:3133-3137.
20 +
Weis SH, Saxinger WC, Ginzburg HM, et al:  Human T-cell lymphotropic virus type I (HLTV-I) and HIV prevalence among US drug abusers (DA). Proc Am Soc Clin Oncol 1987;;6:4.

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