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Ruptured Chordae Tendineae and Acute Pulmonary Edema Induced by Exercise: Title and subTitle BreakOccurrence in a Young Man With Mitral Valve Prolapse FREE

Franklin H. Zimmerman, MD; Allen H. Mogtader, MD
[+] Author Affiliations

Reprint requests to Division of Cardiology, Medical Service, St Luke's Hospital Center, Amsterdam Avenue and 114th Street, New York, NY 10025 (Dr Mogtader).


JAMA. 1987;258(6):812-813. doi:10.1001/jama.1987.03400060088036
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AUSCULTATORY or echocardiographic evidence of mitral valve prolapse may be present in up to 10% of healthy individuals.1,2 Although mitral valve prolapse is generally considered benign, complications are occasionally associated with this condition, including bacterial endocarditis, embolic phenomenon, arrhythmias, and progressive mitral insufficiency.3 A subset of patients with mitral valve prolapse will develop severe mitral insufficiency directly related to rupture of previously intact chordae tendineae. It has been hypothesized that strenuous exertion may predispose to this complication,4,5 but there has been no conclusive clinical evidence to support this concern. This report is the first to our knowledge to describe a patient with mitral valve prolapse who developed acute chordal rupture and pulmonary edema related to vigorous exercise.

Report of a Case  A 26-year-old man was evaluated at another medical center for a "loud" heart murmur, which was discovered during a routine physical examination performed for insurance purposes.

REFERENCES

Markiewicz W, Stoner J, London E, et al:  Mitral valve prolapse in 100 presumably healthy females . Circulation 1976;;53:464-473.
Darsee JR, Mikolick JR, Nicoloff NB, et al:  Prevalence of mitral valve prolapse in presumably healthy men . Circulation 1979;;59:619-622.
Barlow JB, Pockock WA:  The mitral valve prolapse enigma: Two decades later . Mod Concepts Cardiovasc Dis 1984;;53:13-17.
Jeresaty RM:  Mitral valve prolapse: Definition and implications in athletes . J Am Coll Cardiol 1986;;7:231-236.
Jeresaty RM, Edwards JE, Surrendra CK:  Mitral valve prolapse and ruptured chordae tendineae . Am J Cardiol 1985;;55:138-142.
Mintz GM, Kotler MN, Segal BL, et al:  Two-dimensional echocardiographic recognition of ruptured chordae tendineae . Circulation 1978;;57: 244-250.
Hickey AJ, Wilcken DEL, Wright JS, et al:  Primary (spontaneous) chordal rupture: Relation to myxomatous valve disease and mitral valve prolapse . J Am Coll Cardiol 1985;;5:1341-1346.
Van Der Bel—Kahn J, Duren DR, Becker AE:  Isolated mitral valve prolapse: Chordal architecture as an anatomic basis in older patients . J Am Coll Cardiol 1985;;5:1335-1340.
Selzer A, Katayama F:  Mitral regurgitation: Clinical patterns, pathophysiology and natural history . Medicine 1972;;51:337-366.
Oliveira DGB, Dawkins KDD, Kay PH, et al:  Chordal rupture: Aetiology and natural history . Br Heart J 1983;;50:312-317.
Hutchins GM, Moore GW, Skoog DK:  The association of floppy mitral valve with disjunction of the mitral annulus fibrosis . N Engl J Med 1986;; 314:535-540.
Cheitlin MD, Bonow RO, Parmley WW, et al:  Task force II: Acquired valvular heart disease . J Am Coll Cardiol 1985;;6:1209-1214.
Maron BJ, Gaffney FA, Jeresaty RM, et al:  Task force III: Hypertrophic cardiomyopathy, other myopericardial diseases and mitral valve prolapse . J Am Coll Cardiol 1985;;6:1215-1217.
Nishimura RA, McGoon DM, Shub C, et al:  Echocardiographically documented mitral valve prolapse: Long-term follow-up of 237 patients . N Engl J Med 1985;;313:1305-1309.

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Markiewicz W, Stoner J, London E, et al:  Mitral valve prolapse in 100 presumably healthy females . Circulation 1976;;53:464-473.
Darsee JR, Mikolick JR, Nicoloff NB, et al:  Prevalence of mitral valve prolapse in presumably healthy men . Circulation 1979;;59:619-622.
Barlow JB, Pockock WA:  The mitral valve prolapse enigma: Two decades later . Mod Concepts Cardiovasc Dis 1984;;53:13-17.
Jeresaty RM:  Mitral valve prolapse: Definition and implications in athletes . J Am Coll Cardiol 1986;;7:231-236.
Jeresaty RM, Edwards JE, Surrendra CK:  Mitral valve prolapse and ruptured chordae tendineae . Am J Cardiol 1985;;55:138-142.
Mintz GM, Kotler MN, Segal BL, et al:  Two-dimensional echocardiographic recognition of ruptured chordae tendineae . Circulation 1978;;57: 244-250.
Hickey AJ, Wilcken DEL, Wright JS, et al:  Primary (spontaneous) chordal rupture: Relation to myxomatous valve disease and mitral valve prolapse . J Am Coll Cardiol 1985;;5:1341-1346.
Van Der Bel—Kahn J, Duren DR, Becker AE:  Isolated mitral valve prolapse: Chordal architecture as an anatomic basis in older patients . J Am Coll Cardiol 1985;;5:1335-1340.
Selzer A, Katayama F:  Mitral regurgitation: Clinical patterns, pathophysiology and natural history . Medicine 1972;;51:337-366.
Oliveira DGB, Dawkins KDD, Kay PH, et al:  Chordal rupture: Aetiology and natural history . Br Heart J 1983;;50:312-317.
Hutchins GM, Moore GW, Skoog DK:  The association of floppy mitral valve with disjunction of the mitral annulus fibrosis . N Engl J Med 1986;; 314:535-540.
Cheitlin MD, Bonow RO, Parmley WW, et al:  Task force II: Acquired valvular heart disease . J Am Coll Cardiol 1985;;6:1209-1214.
Maron BJ, Gaffney FA, Jeresaty RM, et al:  Task force III: Hypertrophic cardiomyopathy, other myopericardial diseases and mitral valve prolapse . J Am Coll Cardiol 1985;;6:1215-1217.
Nishimura RA, McGoon DM, Shub C, et al:  Echocardiographically documented mitral valve prolapse: Long-term follow-up of 237 patients . N Engl J Med 1985;;313:1305-1309.
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