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ARTICLE |

Immunohematologic Diseases FREE

Ethel Patten, MD
JAMA. 1987;258(20):2945-2951. doi:10.1001/jama.1987.03400200151018
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IN 1900, Karl Landsteiner discovered that sera from some of his laboratory workers would agglutinate red blood cells from certain other laboratory workers. This observation led to the discovery of the ABO blood group system and greatly improved the success of blood transfusion. Until 1945, when Coombs, Mourant, and Race developed the antiglobulin test, it was possible to detect only "complete" agglutinating antibodies, most of which are IgM. However, the antiglobulin test permitted the detection of "incomplete" IgG antibodies and led to the discovery of the Rhesus (Rh), Kell, Kidd, Duffy, and other blood group systems (Table 14-1).

The antiglobulin test forms the basis of the crossmatch, the antibody screening procedures, and the diagnostic tests for autoimmune hemolytic anemia. Antibodies directed against IgG and complement are prepared by immunizing rabbits with purified human globulin. The anti-human globulin (Coombs' serum) causes agglutination of red blood cells coated with IgG antibody or

REFERENCES

Giblett ER:  Blood group alloantibodies: An assessment of some laboratory practices . Transfusion 1977;;17:299-308.
Pineda AA, Brzica SM, Taswell HF:  Hemolytic transfusion reaction: Recent experience in a large blood bank . Mayo Clin Proc 1978;;53:378-390.
Honig CL, Bove JR:  Transfusion-associated fatalities: Review of Bureau of Biologics Reports 1976-1978 . Transfusion 1980;;20:653-661.
Goldfinger D:  Acute hemolytic transfusion reactions: A fresh look at pathogenesis and considerations regarding therapy . Transfusion 1977;;17: 85-98.
Pineda AA, Taswell HG, Brzica SM:  Delayed hemolytic transfusion reaction: An immunologic hazard of blood transfusion . Transfusion 1978;;18: 1-7.
Petz LD, Branch DR:  Drug induced immune hemolytic anemia , in Chaplin H (ed): Methods in Hematology: Immune Hemolytic Anemias . New York, Churchill Livingstone, 1985;, vol 12, pp 47-94.
Kelton JG:  Impaired reticuloendothelial function in patients treated with methyldopa . N Engl J Med 1985;;313:596-600.
Kickler TS, Ness PM, Herman JH, et al:  Studies on the pathophysiology of posttransfusion purpura . Blood 1986;;68:347-350.
Deaver JE, Leppert PC, Zaroulis CG:  Neonatal alloimmune thrombocytopenic purpura . Am J Perinatol 1986;;3:127-131.
Burns TR, Saleem A:  Idiopathic thrombocytopenic purpura . Am J Med 1983;;75:1001-1007.
Kelton JG:  Management of the pregnant patient with idiopathic thrombocytopenic purpura . Ann Intern Med 1983;;99:796-800.
Billett JN, Caren LD:  Human granulocyte antigens: Current status and biological significance . Proc Soc Exp Biol Med 1985;;178:12-23.
DeRie MA, van der Plas-van Dalen CM, Engelfriet CP, et al:  The serology of febrile transfusion reactions . Vox Sang 1985;;49:126-134.
Yomtovian R, Kline W, Press C, et al:  Severe pulmonary hypersensitivity associated with passive transfusion of a neutrophil-specific antibody . Lancet 1984;;1:244-245.
Minchinton RM, Waters AH:  The occurrence and significance of neutrophil antibodies . Br J Haematol 1984;;56:521-528.
Lewin M, Moore A, Weksler BB:  Hematology , in Andreoli TE, Carpenter CCJ, Plum F, et al (eds): Cecil Essentials of Medicine . Philadelphia, WB Saunders Co, 1986;, pp 378-383.
Foon KA, Todd RF:  Immunologic classification of leukemia and lymphoma . Blood 1986;;68:1-31.
Bennett JM, Catovsky D, Daniel M, et al:  Proposals for the classification of the acute leukemias . Br J Haematol 1976;;33:451.
Neame PB, Soamboonsrup P, Browman GP, et al:  Classifying acute leukemia by immunophenotyping: A combined FAB-immunologic classification of AML . Blood 1986;;68:1355-1362.
The Non-Hodgkin's Lymphoma Pathologic Classification Project:  National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage . Cancer 1982;;49: 2112-2135.
Hait WN, Farber L, Cadman E:  Non-Hodgkin's lymphoma for the nononcologist . JAMA 1985;; 253:1431-1435.

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Giblett ER:  Blood group alloantibodies: An assessment of some laboratory practices . Transfusion 1977;;17:299-308.
Pineda AA, Brzica SM, Taswell HF:  Hemolytic transfusion reaction: Recent experience in a large blood bank . Mayo Clin Proc 1978;;53:378-390.
Honig CL, Bove JR:  Transfusion-associated fatalities: Review of Bureau of Biologics Reports 1976-1978 . Transfusion 1980;;20:653-661.
Goldfinger D:  Acute hemolytic transfusion reactions: A fresh look at pathogenesis and considerations regarding therapy . Transfusion 1977;;17: 85-98.
Pineda AA, Taswell HG, Brzica SM:  Delayed hemolytic transfusion reaction: An immunologic hazard of blood transfusion . Transfusion 1978;;18: 1-7.
Petz LD, Branch DR:  Drug induced immune hemolytic anemia , in Chaplin H (ed): Methods in Hematology: Immune Hemolytic Anemias . New York, Churchill Livingstone, 1985;, vol 12, pp 47-94.
Kelton JG:  Impaired reticuloendothelial function in patients treated with methyldopa . N Engl J Med 1985;;313:596-600.
Kickler TS, Ness PM, Herman JH, et al:  Studies on the pathophysiology of posttransfusion purpura . Blood 1986;;68:347-350.
Deaver JE, Leppert PC, Zaroulis CG:  Neonatal alloimmune thrombocytopenic purpura . Am J Perinatol 1986;;3:127-131.
Burns TR, Saleem A:  Idiopathic thrombocytopenic purpura . Am J Med 1983;;75:1001-1007.
Kelton JG:  Management of the pregnant patient with idiopathic thrombocytopenic purpura . Ann Intern Med 1983;;99:796-800.
Billett JN, Caren LD:  Human granulocyte antigens: Current status and biological significance . Proc Soc Exp Biol Med 1985;;178:12-23.
DeRie MA, van der Plas-van Dalen CM, Engelfriet CP, et al:  The serology of febrile transfusion reactions . Vox Sang 1985;;49:126-134.
Yomtovian R, Kline W, Press C, et al:  Severe pulmonary hypersensitivity associated with passive transfusion of a neutrophil-specific antibody . Lancet 1984;;1:244-245.
Minchinton RM, Waters AH:  The occurrence and significance of neutrophil antibodies . Br J Haematol 1984;;56:521-528.
Lewin M, Moore A, Weksler BB:  Hematology , in Andreoli TE, Carpenter CCJ, Plum F, et al (eds): Cecil Essentials of Medicine . Philadelphia, WB Saunders Co, 1986;, pp 378-383.
Foon KA, Todd RF:  Immunologic classification of leukemia and lymphoma . Blood 1986;;68:1-31.
Bennett JM, Catovsky D, Daniel M, et al:  Proposals for the classification of the acute leukemias . Br J Haematol 1976;;33:451.
Neame PB, Soamboonsrup P, Browman GP, et al:  Classifying acute leukemia by immunophenotyping: A combined FAB-immunologic classification of AML . Blood 1986;;68:1355-1362.
The Non-Hodgkin's Lymphoma Pathologic Classification Project:  National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: Summary and description of a working formulation for clinical usage . Cancer 1982;;49: 2112-2135.
Hait WN, Farber L, Cadman E:  Non-Hodgkin's lymphoma for the nononcologist . JAMA 1985;; 253:1431-1435.
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