0
ARTICLE |

Vaginal Spermicides and Congenital Disorders: The Validity of a Study FREE

Richard N. Watkins, MD
JAMA. 1986;256(22):3095-3095. doi:10.1001/jama.1986.03380220061018
Text Size: A A A
Published online

To the Editor.—  In April 1981, an article by Jick et al,1 of which I was a coauthor, suggested that a mother's exposure to spermicide "near the time of conception" might cause certain birth defects. Our article was not corroborated by subsequent studies.2 An expert panel assembled by the Food and Drug Administration found our study unpersuasive because of poor design and unsupported by well-designed studies (Proceedings of the Fertility and Maternal Health Drugs Advisory Committee, unpublished transcript. Food and Drug Administration, Dec 15, 1983). It is the purpose of this letter to allay further long-persisting concern generated by our article by showing that it was based on an inaccurate presumption of exposure to spermicide near the time of conception.In our study, a mother was "presumed to have used vaginal spermicides near the time of conception" if she had received a prescription for spermicides within 600 days

REFERENCES

Jick H, Walker AM, Rothman KJ, et al:  Vaginal spermicides and congenital disorders . JAMA 1981;;245:1329-1332.
Bracken MB:  Spermicidal contraceptives and poor reproductive outcomes: The epidemiologic evidence against an association . Am J Obstet Gynecol 1985;;151:552-556.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Jick H, Walker AM, Rothman KJ, et al:  Vaginal spermicides and congenital disorders . JAMA 1981;;245:1329-1332.
Bracken MB:  Spermicidal contraceptives and poor reproductive outcomes: The epidemiologic evidence against an association . Am J Obstet Gynecol 1985;;151:552-556.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.