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November 21, 1986, Vol 256, No. 19 >
ARTICLE | November 21, 1986

Transfusion-Acquired Babesiosis and Failure of Antibiotic Treatment FREE

Robert P. Smith, MD, MPH; Arthur T. Evans, MD; Mark Popovsky, MD; Letha Mills, MD; Andrew Spielman, ScD
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Reprints not available.


JAMA. 1986;256(19):2726-2727. doi:10.1001/jama.1986.03380190096034
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References

HUMAN babesiosis is a zoonosis characterized by fever, malaise, and hemolytic anemia. In the United States, the disease is generally caused by the species Babesia microti, a protozoan parasite of rodents, and is transmitted by Ixodes dammini, the northern deer tick.1 Most of the 200 known cases of human babesiosis in the United States followed exposure to I dammini on the coastal islands of the Northeast, particularly Nantucket Island, Massachusetts, and Shelter Island, New York. Asymptomatic infections occur frequently2 and create potential for transmission of infection through blood donation.3-6 Recently the range of I dammini, which is also the principal vector of Lyme disease, has increased dramatically, with a resulting increase in the incidence of human babesiosis and Lyme disease.7

Herein we report the first case of babesiosis acquired in New Hampshire and cite evidence indicating that the infection was transfusion acquired. This case also documents

REFERENCES

1 +
Spielman A:  Human babesiosis on Nantucket Island: Transmission by nymphal Ixodes ticks . Am J Trop Med Hyg 1976;;25:784-787.
2 +
Ruebush TK, Juranek DD, Chisholm ES, et al:  Human babesiosis on Nantucket Island: Evidence for self-limited and subclinical infections . N Engl J Med 1977;;297:823-827.
3 +
Jacoby GA, Hunt JV, Kosinski KS, et al:  Treatment of transfusion-transmitted babesiosis by exchange transfusion . N Engl J Med 1980;; 303:1098-1100.
4 +
Marcus LC, Valigorsky JM, Fanning WL, et al:  A case report of transfusion-induced babesiosis . JAMA 1982;;248:465-468.
5 +
Wittner M, Rowin K, Tanowitz H, et al:  Successful chemotherapy of transfusion babesiosis . Ann Intern Med 1982;;96:601-604.
6 +
Grabowski EF, Giardina PJV, Goldberg D, et al:  Babesiosis transmitted by a transfusion of frozen-thawed blood . Ann Intern Med 1982;;96:466-467.
7 +
Dammin GJ, Spielman A, Benach L, et al:  The rising incidence of Babesia microti infection . Hum Pathol 1982;;12:398-400.
8 +
Filstein MR, Benach JL, White DJ, et al:  Serosurvey of human babesiosis in New York . J Infect Dis 1980;;141:518-520.
9 +
Miller LH, Neva FA, Gill F:  Failure of chloroquine in human babesiosis (Babesia microti) . Ann Intern Med 1978;;88:200-202.
10 +
Franciolo PB, Keithly JS, Jones T, et al:  Response of babesiosis to pentamidine therapy . Ann Intern Med 1981;;94:326-330.
11 +
Gambert ME, Goldstein EJC, Benach J, et al:  Human babesiosis—clinical and therapeutic considerations . JAMA 1982;;248:3006-3008.
12 +
Rowin KS, Tanowitz HB, Wittner M:  Therapy of experimental babesiosis . Ann Intern Med 1982;; 97:556-558.
13 +
Dammin GJ, Spielman AS, Mahoney EB, et al:  Clindamycin and quinine treatment for Babesia microti infection . MMWR 1983;;32:65-72.
14 +
Young A, Cox FEG:  The effect of beclomethasone on Babesia microti and B. rodhaini infections in rodents . Parasitology 1971;;63:447-453.
15 +
Rosner F, Zarrabi MH, Benach J, et al:  Babesiosis in splenectomized adults—review of 22 reported cases . Am J Med 1984;;76:696-701.
16 +
Spielman A, Etkind P, Piesman J, et al:  Reservoir hosts of human babesiosis on Nantucket Island . Am J Trop Med Hyg 1981;;30:560-565.
17 +
Piesman J, Spielman A:  Human babesiosis on Nantucket Island: Prevalence of Babesia microti in ticks . Am J Trop Med Hyg 1980;;29:742-746.
18 +
Steketee RW, Eckman MR, Burgess EC, et al:  Babesiosis in Wisconsin . JAMA 1985;;253:2675-2678.
19 +
Spielman A, Wilson ML, Levine JF, et al:  Ecology of Ixodes dammini-borne human babesiosis and Lyme disease . Annu Rev Entomol 1985;; 30:439-460.
20 +
Benach JL, Coleman JL, Habicht GS:  Serological evidence for simultaneous occurrences of Lyme disease and babesiosis . J Infect Dis 1985;;152:473-477.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Spielman A:  Human babesiosis on Nantucket Island: Transmission by nymphal Ixodes ticks . Am J Trop Med Hyg 1976;;25:784-787.
2 +
Ruebush TK, Juranek DD, Chisholm ES, et al:  Human babesiosis on Nantucket Island: Evidence for self-limited and subclinical infections . N Engl J Med 1977;;297:823-827.
3 +
Jacoby GA, Hunt JV, Kosinski KS, et al:  Treatment of transfusion-transmitted babesiosis by exchange transfusion . N Engl J Med 1980;; 303:1098-1100.
4 +
Marcus LC, Valigorsky JM, Fanning WL, et al:  A case report of transfusion-induced babesiosis . JAMA 1982;;248:465-468.
5 +
Wittner M, Rowin K, Tanowitz H, et al:  Successful chemotherapy of transfusion babesiosis . Ann Intern Med 1982;;96:601-604.
6 +
Grabowski EF, Giardina PJV, Goldberg D, et al:  Babesiosis transmitted by a transfusion of frozen-thawed blood . Ann Intern Med 1982;;96:466-467.
7 +
Dammin GJ, Spielman A, Benach L, et al:  The rising incidence of Babesia microti infection . Hum Pathol 1982;;12:398-400.
8 +
Filstein MR, Benach JL, White DJ, et al:  Serosurvey of human babesiosis in New York . J Infect Dis 1980;;141:518-520.
9 +
Miller LH, Neva FA, Gill F:  Failure of chloroquine in human babesiosis (Babesia microti) . Ann Intern Med 1978;;88:200-202.
10 +
Franciolo PB, Keithly JS, Jones T, et al:  Response of babesiosis to pentamidine therapy . Ann Intern Med 1981;;94:326-330.
11 +
Gambert ME, Goldstein EJC, Benach J, et al:  Human babesiosis—clinical and therapeutic considerations . JAMA 1982;;248:3006-3008.
12 +
Rowin KS, Tanowitz HB, Wittner M:  Therapy of experimental babesiosis . Ann Intern Med 1982;; 97:556-558.
13 +
Dammin GJ, Spielman AS, Mahoney EB, et al:  Clindamycin and quinine treatment for Babesia microti infection . MMWR 1983;;32:65-72.
14 +
Young A, Cox FEG:  The effect of beclomethasone on Babesia microti and B. rodhaini infections in rodents . Parasitology 1971;;63:447-453.
15 +
Rosner F, Zarrabi MH, Benach J, et al:  Babesiosis in splenectomized adults—review of 22 reported cases . Am J Med 1984;;76:696-701.
16 +
Spielman A, Etkind P, Piesman J, et al:  Reservoir hosts of human babesiosis on Nantucket Island . Am J Trop Med Hyg 1981;;30:560-565.
17 +
Piesman J, Spielman A:  Human babesiosis on Nantucket Island: Prevalence of Babesia microti in ticks . Am J Trop Med Hyg 1980;;29:742-746.
18 +
Steketee RW, Eckman MR, Burgess EC, et al:  Babesiosis in Wisconsin . JAMA 1985;;253:2675-2678.
19 +
Spielman A, Wilson ML, Levine JF, et al:  Ecology of Ixodes dammini-borne human babesiosis and Lyme disease . Annu Rev Entomol 1985;; 30:439-460.
20 +
Benach JL, Coleman JL, Habicht GS:  Serological evidence for simultaneous occurrences of Lyme disease and babesiosis . J Infect Dis 1985;;152:473-477.

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