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November 7, 1986, Vol 256, No. 17 >
ARTICLE | November 7, 1986

Polymyositis Associated With AIDS Retrovirus FREE

Marinos C. Dalakas, MD; G. H. Pezeshkpour, MD; Maneth Gravell, PhD; John L. Sever, MD, PhD
[+] Author Affiliations

Reprint requests to National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bldg 36, Room 5 D-06, Bethesda, MD 20892 (Dr Dalakas).


JAMA. 1986;256(17):2381-2383. doi:10.1001/jama.1986.03380170097026
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References

Two homosexual men were initially seen with polymyositis as the only manifestation of the acquired immunodeficiency syndrome (AIDS) retrovirus infection. They developed AIDS-related complex a few weeks later and typical AIDS two to six months after onset of muscle weakness. By use of anti-human T-cell lymphotropic virus type III antiserum and monoclonal antibodies to lymphocyte subsets in an immunofluorescence technique, viral antigens were found in the OKT4-positive lymphoid cells surrounding muscle fibers and invading the endomysia septa. We concluded that an initial infection with the AIDS retrovirus can be associated with polymyositis, which may be the first clinical manifestation of an impending AIDS-related complex or AIDS.

(JAMA 1986;256:2381-2383)

REFERENCES

1 +
Snider WD, Simpson DM, Nielsen S, et al:  Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients . Ann Neurol 1983;;14:403-418.
2 +
Zeigler JL, Abrams DI:  The AIDS-related complex , in De Vita VT, Hellman S, Rosenberg SA (eds): AIDS: Etiology, Diagnosis, Treatment and Prevention . New York, JB Lippincott, 1985;, pp 223-233.
3 +
Lipkin WI, Parry G, Kiprov D, et al:  Inflammatory neuropathy in homosexual men with lymphadenopathy . Neurology 1985;;35:1471-1483.
4 +
Engel WK:  Selective and nonselective susceptibility of muscle fiber types: A new approach to human neuromuscular diseases . Arch Neurol 1970;; 2297-117.
5 +
Dalakas MC, Engel WK:  Immunoglobulin deposits in chronic relapsing polyneuropathies . Arch Neurol 1980;;37:637-640.
6 +
Dalakas MC, London WT, Gravell M, et al:  Polymyositis in an immunodeficiency disease in monkeys induced by a type D retrovirus . Neurology 1986;;36:569-572.
7 +
Dalakas MC, London WT, Gravell M, et al:  Polymyositis in monkeys with acquired immunodeficiency can be transmitted with blood or filtered plasma . Neurology 1984;;34( (suppl 1) ):81.
8 +
Dalakas MC:  Development of polymyositis in monkeys with acquired immunodeficiency . Neurology 1984;;34( (suppl 1) ):192.
9 +
London WT, Madden DL, Gravell M, et al:  Experimental transmission of simian acquired immunodeficiency syndrome (SAIDS) and Kaposilike lesions . Lancet 1983;;2:869-873.
10 +
Gravell M, London WT, Houff SA, et al:  Transmission of simian acquired immunodeficiency syndrome (SAIDS) with blood or filtered plasma . Science 1984;;223:74-76.
11 +
Gravell M, London WT, Hamilton RS, et al:  Transmission of simian acquired immunodeficiency syndrome (SAIDS) with a type D retrovirus isolate . Lancet 1984;;1:334-335.
12 +
Dalakas MC, Engel WK:  Chronic relapsing (dysimmune) polyneuropathy: Pathogenesis and treatment . Ann Neurol 1981;;9( (suppl) ):134-145.
13 +
Dalakas MC, Pezeshkpour GH:  Neuromuscular complications of AIDS . Muscle Nerve 1986;; 9:26.
14 +
Penn AS:  Myasthenia gravis, dermatomyositis and polymyositis: Immunopathological diseases . Adv Neurol 1977;;17:41-61.

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Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Snider WD, Simpson DM, Nielsen S, et al:  Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients . Ann Neurol 1983;;14:403-418.
2 +
Zeigler JL, Abrams DI:  The AIDS-related complex , in De Vita VT, Hellman S, Rosenberg SA (eds): AIDS: Etiology, Diagnosis, Treatment and Prevention . New York, JB Lippincott, 1985;, pp 223-233.
3 +
Lipkin WI, Parry G, Kiprov D, et al:  Inflammatory neuropathy in homosexual men with lymphadenopathy . Neurology 1985;;35:1471-1483.
4 +
Engel WK:  Selective and nonselective susceptibility of muscle fiber types: A new approach to human neuromuscular diseases . Arch Neurol 1970;; 2297-117.
5 +
Dalakas MC, Engel WK:  Immunoglobulin deposits in chronic relapsing polyneuropathies . Arch Neurol 1980;;37:637-640.
6 +
Dalakas MC, London WT, Gravell M, et al:  Polymyositis in an immunodeficiency disease in monkeys induced by a type D retrovirus . Neurology 1986;;36:569-572.
7 +
Dalakas MC, London WT, Gravell M, et al:  Polymyositis in monkeys with acquired immunodeficiency can be transmitted with blood or filtered plasma . Neurology 1984;;34( (suppl 1) ):81.
8 +
Dalakas MC:  Development of polymyositis in monkeys with acquired immunodeficiency . Neurology 1984;;34( (suppl 1) ):192.
9 +
London WT, Madden DL, Gravell M, et al:  Experimental transmission of simian acquired immunodeficiency syndrome (SAIDS) and Kaposilike lesions . Lancet 1983;;2:869-873.
10 +
Gravell M, London WT, Houff SA, et al:  Transmission of simian acquired immunodeficiency syndrome (SAIDS) with blood or filtered plasma . Science 1984;;223:74-76.
11 +
Gravell M, London WT, Hamilton RS, et al:  Transmission of simian acquired immunodeficiency syndrome (SAIDS) with a type D retrovirus isolate . Lancet 1984;;1:334-335.
12 +
Dalakas MC, Engel WK:  Chronic relapsing (dysimmune) polyneuropathy: Pathogenesis and treatment . Ann Neurol 1981;;9( (suppl) ):134-145.
13 +
Dalakas MC, Pezeshkpour GH:  Neuromuscular complications of AIDS . Muscle Nerve 1986;; 9:26.
14 +
Penn AS:  Myasthenia gravis, dermatomyositis and polymyositis: Immunopathological diseases . Adv Neurol 1977;;17:41-61.

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