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January 17, 1986, Vol 255, No. 3 >
ARTICLE | January 17, 1986

Campylobacter Infection Associated With Raw Milk: Title and subTitle BreakAn Outbreak of Gastroenteritis due to Campylobacter jejuni and Thermotolerant Campylobacter fetus subsp fetus FREE

Bruce S. Klein, MD; James M. Vergeront, MD; Martin J. Blaser, MD; Paul Edmonds, PhD; Don J. Brenner, PhD; David Janssen; Jeffrey P. Davis, MD
[+] Author Affiliations

Manufacturer's names are listed for identification only and do not imply endorsement by the US Dept of Health and Human Services or the US Public Health Service.

Reprint requests to Division of Infectious Diseases, Room H4/572, Center for Health Sciences, University of Wisconsin, Madison, WI 53792 (Dr Klein).


JAMA. 1986;255(3):361-364. doi:10.1001/jama.1986.03370030081032
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References

Raw milk is identified with increasing numbers of outbreaks of gastroenteritis and is an important vehicle for transmission of Campylobacter infection. Unlike Campylobacter jejuni, Campylobacter fetus subsp fetus has not been associated with common-source outbreaks of gastroenteritis. This report describes an outbreak of gastroenteritis involving C jejuni and a thermotolerant strain of C fetus subsp fetus associated with raw milk. Fifteen (39%) of 38 persons who attended a banquet in Wisconsin in June 1982 developed acute gastroenteritis. Stool specimens were obtained from nine ill guests; four yielded C jejuni and three yielded C fetus subsp fetus. The C fetus subsp fetus isolates were identified fortuitously, in part because of unusual thermotolerance (growth at 42 °C), permitting isolation at temperature appropriate for C jejuni. Survey results implicated raw milk as the source of the outbreak. Findings provide evidence of a potentially emergent milkborne pathogen contributing to the risk of raw milk consumption and suggest that current diagnostic laboratory techniques may fail to identify significant foodborne agents.

(JAMA 1986;255:361-364)

REFERENCES

1 +
Potter ME, Kaufman AF, Blake PA, et al:  Unpasteurized milk: The hazards of a health fetish . JAMA 1984;;252:2048-2052.
2 +
Finch MJ, Blake PA:  Foodborne outbreaks of campylobacteriosis: The United States experience, 1980-1982 . Am J Epidemiol 1985;;122:262-268.
3 +
 Campylobacter sepsis associated with 'nutritional therapy'—California . MMWR 1981;; 30:294-295.
4 +
Guerrant RL, Lahita RG, Winn WC Jr, et al:  Campylobacteriosis in man: Pathogenic mechanisms and review of 91 bloodstream infections . Am J Med 1978;;65:584-592.
5 +
Karmali MA, Fleming PC:  Campylobacter enteritis . Can Med Assoc J 1979;;120:1525-1532.
6 +
Birnboim HC, Doly J:  A rapid alkaline extraction procedure for screening recombinant plasmid DNA . Nucleic Acids Res 1979;;7:1513-1523.
7 +
Brenner DJ, Steigerwalt AG, McDade JE:  Classification of the Legionnaires' disease bacterium: Legionella penumophila, genus novum, species nova, of the family Legionellaceae, familia nova . Ann Intern Med 1979;;90:656-658.
8 +
Johnson RJ, Wang SP, Shelton WR, et al:  Persistent Campylobacter jejuni infection in an immunocompromised patient . Ann Intern Med 1984;;100:832-834.
9 +
Wisconsin Storm Data . Asheville, NC, US Dept of Commerce, National Climatic Data Center, 1981;, vol 23, p 34.
10 +
Smibert RM:  The genus Campylobacter . Ann Rev Microbiol 1978;;32:673-709.
11 +
Blaser MJ, Duncan DJ, Osterholm MT, et al:  Serologic study of two clusters of infection due to Campylobacter jejuni . J Infect Dis 1983;; 147:820-823.
12 +
Skirrow MB:  Campylobacter infections of man , in Easmon CSF, Jeljaszewicz J (eds): Medical Microbiology . Orlando, Fla, Academic Press Inc, 1984;, vol 4, pp 105-141.
13 +
Blaser MJ, Waldman RJ, Barrett T, et al:  Outbreaks of Campylobacter enteritis in two extended families: Evidence for person-to-person transmission . J Pediatr 1981;;98:254-257.
14 +
Blaser MJ, Smith PF, Kohler PF:  Susceptibility of Campylobacter isolates to the bactericidal activity of human serum . J Infect Dis 1985;;151:227-235.
15 +
Lee MM, Welliver RC, La Scolea LJ:  Campylobacter meningitis in childhood . Pediatr Infect Dis 1985;;4:544-547.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Potter ME, Kaufman AF, Blake PA, et al:  Unpasteurized milk: The hazards of a health fetish . JAMA 1984;;252:2048-2052.
2 +
Finch MJ, Blake PA:  Foodborne outbreaks of campylobacteriosis: The United States experience, 1980-1982 . Am J Epidemiol 1985;;122:262-268.
3 +
 Campylobacter sepsis associated with 'nutritional therapy'—California . MMWR 1981;; 30:294-295.
4 +
Guerrant RL, Lahita RG, Winn WC Jr, et al:  Campylobacteriosis in man: Pathogenic mechanisms and review of 91 bloodstream infections . Am J Med 1978;;65:584-592.
5 +
Karmali MA, Fleming PC:  Campylobacter enteritis . Can Med Assoc J 1979;;120:1525-1532.
6 +
Birnboim HC, Doly J:  A rapid alkaline extraction procedure for screening recombinant plasmid DNA . Nucleic Acids Res 1979;;7:1513-1523.
7 +
Brenner DJ, Steigerwalt AG, McDade JE:  Classification of the Legionnaires' disease bacterium: Legionella penumophila, genus novum, species nova, of the family Legionellaceae, familia nova . Ann Intern Med 1979;;90:656-658.
8 +
Johnson RJ, Wang SP, Shelton WR, et al:  Persistent Campylobacter jejuni infection in an immunocompromised patient . Ann Intern Med 1984;;100:832-834.
9 +
Wisconsin Storm Data . Asheville, NC, US Dept of Commerce, National Climatic Data Center, 1981;, vol 23, p 34.
10 +
Smibert RM:  The genus Campylobacter . Ann Rev Microbiol 1978;;32:673-709.
11 +
Blaser MJ, Duncan DJ, Osterholm MT, et al:  Serologic study of two clusters of infection due to Campylobacter jejuni . J Infect Dis 1983;; 147:820-823.
12 +
Skirrow MB:  Campylobacter infections of man , in Easmon CSF, Jeljaszewicz J (eds): Medical Microbiology . Orlando, Fla, Academic Press Inc, 1984;, vol 4, pp 105-141.
13 +
Blaser MJ, Waldman RJ, Barrett T, et al:  Outbreaks of Campylobacter enteritis in two extended families: Evidence for person-to-person transmission . J Pediatr 1981;;98:254-257.
14 +
Blaser MJ, Smith PF, Kohler PF:  Susceptibility of Campylobacter isolates to the bactericidal activity of human serum . J Infect Dis 1985;;151:227-235.
15 +
Lee MM, Welliver RC, La Scolea LJ:  Campylobacter meningitis in childhood . Pediatr Infect Dis 1985;;4:544-547.

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