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ARTICLE |

Acute Myocardial Infarction Following Cocaine Abuse in a Young Woman With Normal Coronary Arteries FREE

Russell E. Howard, MD; David C. Hueter, MD; Gary J. Davis, MD
[+] Author Affiliations

Reprint requests to Room G-348, Evanston Hospital, 2650 Ridge Ave, Evanston, IL 60201 (Dr Hueter).


JAMA. 1985;254(1):95-96. doi:10.1001/jama.1985.03360010101036
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RECREATIONAL use of cocaine has increased dramatically in the last decade. One factor in this trend is the general belief that cocaine is not harmful, a concept supported by the relative scarcity of reports concerning its ill effects. Prior reports of myocardial infarction associated with cocaine occurred in individuals with preexistent angina or myocardial infarction. We report here the case of a young woman without evident heart disease who suffered an acute myocardial infarction associated with cocaine abuse.

Report of a Case  A 28-year-old woman began to use cocaine in her early 20s and gradually increased her use to more than 1 g/day. For the year prior to the day of admission she had abstained from use of this or any other drug. She used no tobacco or oral contraceptives and had normal levels of blood glucose and lipids. There was no personal or family history of cardiovascular disease.On

REFERENCES

Coleman DL, Ross TF, Naughton JL:  Myocardial ischemia and infarction related to recreational cocaine use . West J Med 1982;;136:444-446.
Schachne JS, Roberts BH, Thompson PD:  Coronary artery spasm and myocardial infarction associated with cocaine use . N Engl J Med 1984;;310:1665-1666.
Muscholl E:  Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen . Br J Pharmacol 1961;;62:352-359.
Frohlich A, Loewi 0:  Über eine Steigerung der Adrenalinempfindlichkeit durch Cocain . Arch Exp Pathol Pharm 1910;;62:159-169.
Fischman MW, Schuster CR, Resnekov L, et al:  Cardiovascular and subjective effects of intravenous cocaine administration in humans . Arch Gen Psychiatry 1976;;33:983-989.
Fernandez MS, Pichard AD, Marchant E, et al:  Acute myocardial infarction with normal coronary arteries . Clin Cardiol 1983;;6:553-559.
Zucker MB:  Platelet function , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology , ed 4. New York, McGraw-Hill Book Co, 1983;, p 1179.
Folts JD, Bonebrake FC:  The effects of cigarette smoke and nicotine on platelet thrombus formation in stenosed dog coronary arteries . Circulation 1982;;65:465-470.
Bowen JS, David GB, Kearney TE, et al:  Diffuse vascular spasm associated with 4-bromo-2,5-diethoxyamphetamine ingestion . JAMA 1983;;249:1477-1479.

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Coleman DL, Ross TF, Naughton JL:  Myocardial ischemia and infarction related to recreational cocaine use . West J Med 1982;;136:444-446.
Schachne JS, Roberts BH, Thompson PD:  Coronary artery spasm and myocardial infarction associated with cocaine use . N Engl J Med 1984;;310:1665-1666.
Muscholl E:  Effect of cocaine and related drugs on the uptake of noradrenaline by heart and spleen . Br J Pharmacol 1961;;62:352-359.
Frohlich A, Loewi 0:  Über eine Steigerung der Adrenalinempfindlichkeit durch Cocain . Arch Exp Pathol Pharm 1910;;62:159-169.
Fischman MW, Schuster CR, Resnekov L, et al:  Cardiovascular and subjective effects of intravenous cocaine administration in humans . Arch Gen Psychiatry 1976;;33:983-989.
Fernandez MS, Pichard AD, Marchant E, et al:  Acute myocardial infarction with normal coronary arteries . Clin Cardiol 1983;;6:553-559.
Zucker MB:  Platelet function , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology , ed 4. New York, McGraw-Hill Book Co, 1983;, p 1179.
Folts JD, Bonebrake FC:  The effects of cigarette smoke and nicotine on platelet thrombus formation in stenosed dog coronary arteries . Circulation 1982;;65:465-470.
Bowen JS, David GB, Kearney TE, et al:  Diffuse vascular spasm associated with 4-bromo-2,5-diethoxyamphetamine ingestion . JAMA 1983;;249:1477-1479.
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