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December 20, 1985, Vol 254, No. 23 >
ARTICLE | December 20, 1985

The Case of Baby Fae FREE

Olga Jonasson, MD; Mark A. Hardy, MD
[+] Author Affiliations

Address editorial communications to the Editor, 535 N Dearborn St, Chicago, IL 60610.


JAMA. 1985;254(23):3358-3359. doi:10.1001/jama.1985.03360230090031
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References

Appearing in this issue of The Journal is the first full scientific report of the "case of Baby Fae"—cardiac xenotransplantation in a neonate. Many emotional editorial comments about this case have appeared in the lay press and in respected scientific publications. Critical editorial commentary by peers, based on an impartial analysis of the scientific gathering of the facts, is now appropriate.

The infant, born prematurely with hypoplastic left heart syndrome, an invariably fatal form of congenital heart disease, received the heart of a young female baboon in an uncomplicated surgical procedure on Oct 26, 1984. At the time of transplantation the infant was critically ill, and urgent surgical intervention was required if she was to survive even for a brief interval. Based on his own evaluation of the alternatives, Dr Bailey had offered xenotransplantation to the mother. The alternatives were three: a risky palliative surgical procedure, the Norwood procedure,1

REFERENCES

1 +
Norwood WI, Lang P, Hansen DD:  Physiologic repair of aortic atresia-hypoplastic left heart syndrome . N Engl J Med 1983;;308:23-26.
2 +
Bailey LL,Jang J,Johnson W, et al:  Orthotopic cardiac xenografting in the newborn goat . J Thorac Cardiovasc Surg 1985;;89:242-247.
3 +
Hardy MA, Todd G, Reemtsma K:  Xenotransplantation , in Slavin S (ed): Bone Marrow and Organ Transplantation . Amsterdam, Elsevier Science Publishers BV, 1984;.
4 +
Downing HJ, Brain P, Hammond MG, et al:  Leukocyte antigens of baboons . Transplant Proc 1972;;4:33-36.
5 +
Hammer C, Chaussy C, Brendel W:  Preformed natural antibodies in animals and man . Eur Surg Res 1973;;5:162-166.
6 +
Stiehm ER, Winter HS, Bryson YJ:  Cellular (T cell) immunity in the human newborn . Pediatrics 1979;;64( (suppl) ):814-821.
7 +
Burckart G, Starzl TE, Williams L, et al:  Cyclosporine monitoring and pharmacokinetics in pediatric liver transplant patients . Transplant Proc 1985;;17:1172-1175.
8 +
Reemtsma K, Hardy MA, Drusin RE, et al:  Cardiac transplantation: Changing patterns in evaluation and treatment . Ann Surg 1985;;202:418-424.
9 +
Kahan BD:  Immunologic monitoring: Utility and limitations . Transplant Proc 1985;;17:1537-1545.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Norwood WI, Lang P, Hansen DD:  Physiologic repair of aortic atresia-hypoplastic left heart syndrome . N Engl J Med 1983;;308:23-26.
2 +
Bailey LL,Jang J,Johnson W, et al:  Orthotopic cardiac xenografting in the newborn goat . J Thorac Cardiovasc Surg 1985;;89:242-247.
3 +
Hardy MA, Todd G, Reemtsma K:  Xenotransplantation , in Slavin S (ed): Bone Marrow and Organ Transplantation . Amsterdam, Elsevier Science Publishers BV, 1984;.
4 +
Downing HJ, Brain P, Hammond MG, et al:  Leukocyte antigens of baboons . Transplant Proc 1972;;4:33-36.
5 +
Hammer C, Chaussy C, Brendel W:  Preformed natural antibodies in animals and man . Eur Surg Res 1973;;5:162-166.
6 +
Stiehm ER, Winter HS, Bryson YJ:  Cellular (T cell) immunity in the human newborn . Pediatrics 1979;;64( (suppl) ):814-821.
7 +
Burckart G, Starzl TE, Williams L, et al:  Cyclosporine monitoring and pharmacokinetics in pediatric liver transplant patients . Transplant Proc 1985;;17:1172-1175.
8 +
Reemtsma K, Hardy MA, Drusin RE, et al:  Cardiac transplantation: Changing patterns in evaluation and treatment . Ann Surg 1985;;202:418-424.
9 +
Kahan BD:  Immunologic monitoring: Utility and limitations . Transplant Proc 1985;;17:1537-1545.

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