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January 25, 1985, Vol 253, No. 4 >
ARTICLE | January 25, 1985

Is Hemophilus influenzae Type b Disease Preventable? FREE

Joel I. Ward, MD
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JAMA. 1985;253(4):554-556. doi:10.1001/jama.1985.03350280110031
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References

Invasive disease caused by Hemophilus influenzae type b (HIB) is recognized as a leading pediatric health problem. This agent is the leading cause of bacterial meningitis in the United States and, in addition, causes a wide variety of other serious infections. It is estimated that approximately 20,000 cases of invasive HIB disease occur annually in the United States, affecting one in every 200 children during the first five years of life. This incidence exceeds that of meningococcal disease by several fold and is similar to the peak incidence of paralytic poliomyelitis during the early 1950s. Furthermore, despite the availability of effective antimicrobials, significant morbidity, especially postmeningitic sequelae, and mortality continue. Consequently, there is no debate about the need for an effective vaccine, especially for young infants who are at greatest risk.

It has been known for many years that antibody to the capsular polysaccharide of HIB, polyribosylribitol-phosphate (PRP), is protective

REFERENCES

1 +
Cochi SL, Broome CV, Hightower AW:  Immunization of US Children with Hemophilus influenzae Type b Polysaccharide Vaccine . JAMA 1985;;253:521-529.
2 +
Peltola H, Kayhty H, Virtanen M, et al:  Prevention of Hemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine . N Engl J Med 1984;;310:1561-1566.
3 +
Peltola H, Kayhty H, Sivonen A, et al:  Haemophilus influenzae type b capsular polysaccharide vaccine in children: A double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland . Pediatrics 1977;;60:730-737.
4 +
Makela PH, Peltola H, Kayhty H, et al:  Polysaccharide vaccines of group A Neisseria meningitidis and Haemophilus influenzae type b: A field trial in Finland . J Infect Dis 1977;;136:S43-S50.
5 +
Anderson P:  The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b . J Infect Dis 1984;;149:1034-1035.
6 +
Parke JC Jr, Schneerson R, Robbins JB, et al:  Interim report of a controlled field trial of immunization with capsular polysaccharides of Haemophilus influenzae type b and group C Neisseria meningitidis in Mecklenburg County, North Carolina (March 1974-March 1976) . J Infect Dis 1977;;136:S51-S56.
7 +
Ginsburg CM, McCracken GH Jr, Rae S, et al:  Haemophilus influenzae type b disease . JAMA 1977;;238:604-607.
8 +
McKinney TC, Granoff DM, Bois EG, et al: Haemophilus influenzae type b in an Amish community, program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, October 1984 .
9 +
Redmond SR, Pichichero ME:  Hemophilus influenzae type b disease: An epidemiologic study with special reference to day-care centers . JAMA 1984;;252:2581-2584.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Cochi SL, Broome CV, Hightower AW:  Immunization of US Children with Hemophilus influenzae Type b Polysaccharide Vaccine . JAMA 1985;;253:521-529.
2 +
Peltola H, Kayhty H, Virtanen M, et al:  Prevention of Hemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine . N Engl J Med 1984;;310:1561-1566.
3 +
Peltola H, Kayhty H, Sivonen A, et al:  Haemophilus influenzae type b capsular polysaccharide vaccine in children: A double-blind field study of 100,000 vaccinees 3 months to 5 years of age in Finland . Pediatrics 1977;;60:730-737.
4 +
Makela PH, Peltola H, Kayhty H, et al:  Polysaccharide vaccines of group A Neisseria meningitidis and Haemophilus influenzae type b: A field trial in Finland . J Infect Dis 1977;;136:S43-S50.
5 +
Anderson P:  The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b . J Infect Dis 1984;;149:1034-1035.
6 +
Parke JC Jr, Schneerson R, Robbins JB, et al:  Interim report of a controlled field trial of immunization with capsular polysaccharides of Haemophilus influenzae type b and group C Neisseria meningitidis in Mecklenburg County, North Carolina (March 1974-March 1976) . J Infect Dis 1977;;136:S51-S56.
7 +
Ginsburg CM, McCracken GH Jr, Rae S, et al:  Haemophilus influenzae type b disease . JAMA 1977;;238:604-607.
8 +
McKinney TC, Granoff DM, Bois EG, et al: Haemophilus influenzae type b in an Amish community, program and abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, October 1984 .
9 +
Redmond SR, Pichichero ME:  Hemophilus influenzae type b disease: An epidemiologic study with special reference to day-care centers . JAMA 1984;;252:2581-2584.

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