Fulminant Hepatic Failure Caused by Genital Herpes in a Healthy Person FREE

Michael H. Rubin, MD; Demming M. Ward, MD; C. John Painter, MD

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Reprint requests to Salem Gastroenterology Associates, 1830 S Hawthorne Rd, Winston-Salem, NC 27103 (Dr Rubin).

JAMA. 1985;253(9):1299-1301. doi:10.1001/jama.1985.03350330097031

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ABSTRACT

ABSTRACT | REFERENCES

GENITAL herpes caused by herpes simplex virus, type 2 (HSV-2), has become an increasingly recognized infection in the sexually active population.¹ Among prostitutes,² homosexuals,³ and members of both sexes who attend venereal disease clinics,⁴ the incidence of genital herpes has become alarmingly high, approaching epidemic proportions. Although the infectious nature and distinctive clinical symptom complex of herpes were recognized by the early Greeks, sexual transmission was not emphasized until the late 19th century. That the causative agents responsible for "venereal herpes" and for fever blisters were separate was initially demonstrated in the 1920s by Lipschutz, but this fact was submerged and did not resurface until 1968, when Nahmias and Dowdle⁵ antigenically characterized the two serotypes, HSV-1 and HSV-2.

The herpes virus in other tissues has been reported.^6-13 The early literature concerning herpetic hepatitis dealt mainly with the immunosuppressed individual.⁶ Recently, there have been

REFERENCES

ABSTRACT | REFERENCES

Crusin LM: Syphilis and other sexually transmitted diseases . Cutis 1981;;27:286-306.

Hutfield DC: History of gential herpes . Br J Vener Dis 1966;;42:263-268.

Quinn TC, Corey L, Chaffee RG: The etiology of anorectal infections in homosexual men . Am J Med 1981;;71:395-406.

Nahmias AJ, Josey WE: Epidemiology of herpes simplex viruses 1 and 2 , in Evan ES (ed): Viral Infection of Humans . New York, Plenum Publishing Corp, 1976;, pp 253-271.

Nahmias AJ, Dowdle WR: Antigenic and biologic differences in Herpesvirus hominis . Prog Med Virol 1968;;10:110-159.

Elliott WC, Houghton DC, Bryant RE, et al: Herpes simplex type I hepatitis in renal transplantation . Arch Intern Med 1980;;140:1656-1660.

Joseph TJ, Vogt PJ: Disseminated herpes with hepatoadrenal necrosis in an adult . Am J Med 1974;;56:735-739.

Moedy JW, Lerman SJ, White RJ: Fatal disseminated herpes simplex virus infection in a healthy child . Am J Dis Child 1981;;135:45-47.

Francis TJ, Osuntokum BO, Kemp GE: Fulminant hepatitis due to herpes hominis in an adult human . Am J Gastroenterol 1972;;57:329-332.

Conner RW, Lorts G, Gilbert DN: Lethal herpes simplex type I hepatitis in a normal adult . Gastroenterology 1979;;76:590-594.

Blitzer BL: Fulminant hepatic failure . Postgrad Med 1980;;68:153-162.

Chi'en LT, Cannon NJ, Charamella LJ, et al: Effect of adenine arabinoside on severe Herpesvirus hominis infections in man . J Infect Dis 1973;;128:658-663.

Marrie TJ, McDonald ATJ, Conen PE, et al: Herpes simplex hepatitis—use of immunoperoxidase to demonstrate the viral antigen in hepatocytes . Gastroenterology 1982;;82:71-76.

Schneider V, Behm FG, Mumaw VR: Ascending herpetic endometritis . Obstet Gynecol 1982;;59:259-262.

Keane JT, Malkinson FD, Bryant J, et al: Herpesvirus hominis hepatitis and disseminated intravascular coagulation . Arch Intern Med 1976;;136:1312-1317.

Flewett TH, Parker RGF, Philip WM: Acute hepatitis due to herpes simplex virus in an adult . J Clin Pathol 1969;;22:60-66.

Sullivan SN: Herpes simplex hepatitis . Gastroenterology 1979;;77:426.

Wade JC, Newton B, McLaren C, et al: Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation . Ann Intern Med 1982;;96:265-269.

Corey L, Fife KH, Benedetti JK, et al: Intravenous acyclovir for the treatment of primary genital herpes . Ann Intern Med 1983;; 98:914-921.

Corey L, Nahmias AJ, Guinan ME, et al: A trial of topical acyclovir in gential herpes simplex virus infections . N Engl J Med 1982;; 306:1313-1319.

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