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February 8, 1985, Vol 253, No. 6 >
ARTICLE | February 8, 1985

Adult Scurvy FREE

James B. Reuler, MD; Virginia C. Broudy, MD; Thomas G. Cooney, MD
[+] Author Affiliations

Reprints not available.


JAMA. 1985;253(6):805-807. doi:10.1001/jama.1985.03350300093027
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References

Scurvy is a disease that can mimic other more serious disorders such as deep vein thrombosis, vasculitis, and systemic bleeding disorders. Because the clinical features of scurvy are no longer well appreciated, scorbutic patients are often extensively evaluated for other disorders. Familiarity with the risk factors for and clinical manifestation of scurvy can facilitate earlier diagnosis. We report three patients who highlight the epidemiology, clinical features, and differential diagnosis of scurvy.

(JAMA 1985;253:805-807)

REFERENCES

1 +
Hodges RE:  Ascorbic acid , in Goodhart RS, Shils ME (eds): Modern Nutrition in Health and Disease , ed 6. Philadelphia, Lea & Febiger, 1980;, pp 259-273.
2 +
Walker A:  Chronic scurvy . Br J Dermatol 1968;;80:625-630.
3 +
Leung FW, Guze PA:  Adult scurvy . Ann Emerg Med 1981;;10:652-655.
4 +
Dogramaci I:  Scurvy: A survey of 241 cases . N Engl J Med 1946;;235:183-187.
5 +
Nydegger UE, Miescher PA:  Bleeding due to vascular disorders . Semin Hematol 1980;;17:178-191.
6 +
Crandon JH, Lund CC, Dill DB:  Experimental human scurvy . N Engl J Med 1940;;223:353-369.
7 +
Hodges RE, Baker EM, Hood J, et al:  Experimental scurvy in man . Am J Clin Nutr 1969;;22:535-548.
8 +
Hodges RE:  Nutrition and the integument including mucous membranes , in Hodges RE (ed): Nutrition in Medical Practice . Philadelphia, WB Saunders Co, 1980;, pp 265-287.
9 +
Sherlock P, Rothschild EO:  Scurvy produced by a Zen macrobiotic diet . JAMA 1967;; 199:130-134.
10 +
Stolman JM, Goldman HM, Gould GS:  Ascorbic acid and blood vessels: The formation and maintenance of connective tissue and blood vessels within polyvinyl sponge implants in ascorbic acid supplemented and ascorbic acid depleted guinea pigs . Arch Pathol 1961;;72:535-545.
11 +
Wilson PA, McNicol GP, Douglas AS:  Platelet abnormality in human scurvy . Lancet 1967;;1:975-978.
12 +
Johnson GJ, Holloway DE, Hutton SW, et al:  Platelet function in scurvy and experimental human vitamin C deficiency . Thromb Res 1981;; 24:85-93.
13 +
Hood J, Hodges RE:  Ocular lesions in scurvy . Am J Clin Nutr 1969;;22:559-567.
14 +
Bevelaqua FA, Hasselbacher P, Schumacher HR:  Scurvy and hemarthrosis . JAMA 1976;;235:1874-1876.
15 +
Hood J:  Femoral neuropathy in scurvy . N Engl J Med 1969;;281:1292-1293.
16 +
Charbeneau TD, Hurt WC:  Gingival findings in spontaneous scurvy: A case report . J Periodontol 1983;;54:694-697.
17 +
Vilter RW, Woolford RM, Spies TD:  Severe scurvy: A clinical and hematologic study . J Lab Clin Med 1946;;31:609-630.
18 +
Goldberg A:  The anemia of scurvy . Q J Med 1963;;32:51-64.
19 +
Cox EV:  The anemia of scurvy . Vitam Horm 1968;;26:635-652.
20 +
Roeser HP:  The role of ascorbic acid in the turnover of storage iron . Semin Hematol 1983;; 20:91-100.
21 +
Stokes PL, Melikian V, Leeming RL, et al:  Folate metabolism in scurvy . Am J Clin Nutr 1975;;28:126-129.
22 +
Follis RH:  Sudden death in infants with scurvy . J Pediatr 1942;;20:347-351.
23 +
Abboud FM, Hood J, Hodges RE, et al:  Autonomic reflexes and vascular reactivity in experimental scurvy in man . J Clin Invest 1970;; 49:298-307.
24 +
Minor RR:  Collagen metabolism: A comparison of diseases of collagen and diseases affecting collagen . Am J Pathol 1980;;98:227-279.
25 +
Chojkier M, Spanheimer R, Peterkofsky B:  Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss: In vitro studies in guinea pig calvarial bones . J Clin Invest 1983;;72:826-835.
26 +
Sauberlich HE:  Vitamin C status: Methods and findings . Ann NY Acad Sci 1975;;258:438-450.
27 +
Hiebert CA:  Gastroesophageal reflux and ascorbic acid deficiency . Ann Thoracic Surg 1977;;24:108-112.
28 +
Sullivan JF, Eisenstein AB, Mottola OM, et al:  The effect of dialysis on plasma and tissue levels of vitamin C . Trans Am Soc Artif Intern Organs 1972;;18:277-282.
29 +
DeBari VA, Frank O, Baker H, et al:  Water soluble vitamins in granulocytes, erythrocytes, and plasma obtained from chronic hemodialysis patients . Am J Clin Nutr 1984;;39:410-415.

Figures

Tables

Interactive Graphics

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Hodges RE:  Ascorbic acid , in Goodhart RS, Shils ME (eds): Modern Nutrition in Health and Disease , ed 6. Philadelphia, Lea & Febiger, 1980;, pp 259-273.
2 +
Walker A:  Chronic scurvy . Br J Dermatol 1968;;80:625-630.
3 +
Leung FW, Guze PA:  Adult scurvy . Ann Emerg Med 1981;;10:652-655.
4 +
Dogramaci I:  Scurvy: A survey of 241 cases . N Engl J Med 1946;;235:183-187.
5 +
Nydegger UE, Miescher PA:  Bleeding due to vascular disorders . Semin Hematol 1980;;17:178-191.
6 +
Crandon JH, Lund CC, Dill DB:  Experimental human scurvy . N Engl J Med 1940;;223:353-369.
7 +
Hodges RE, Baker EM, Hood J, et al:  Experimental scurvy in man . Am J Clin Nutr 1969;;22:535-548.
8 +
Hodges RE:  Nutrition and the integument including mucous membranes , in Hodges RE (ed): Nutrition in Medical Practice . Philadelphia, WB Saunders Co, 1980;, pp 265-287.
9 +
Sherlock P, Rothschild EO:  Scurvy produced by a Zen macrobiotic diet . JAMA 1967;; 199:130-134.
10 +
Stolman JM, Goldman HM, Gould GS:  Ascorbic acid and blood vessels: The formation and maintenance of connective tissue and blood vessels within polyvinyl sponge implants in ascorbic acid supplemented and ascorbic acid depleted guinea pigs . Arch Pathol 1961;;72:535-545.
11 +
Wilson PA, McNicol GP, Douglas AS:  Platelet abnormality in human scurvy . Lancet 1967;;1:975-978.
12 +
Johnson GJ, Holloway DE, Hutton SW, et al:  Platelet function in scurvy and experimental human vitamin C deficiency . Thromb Res 1981;; 24:85-93.
13 +
Hood J, Hodges RE:  Ocular lesions in scurvy . Am J Clin Nutr 1969;;22:559-567.
14 +
Bevelaqua FA, Hasselbacher P, Schumacher HR:  Scurvy and hemarthrosis . JAMA 1976;;235:1874-1876.
15 +
Hood J:  Femoral neuropathy in scurvy . N Engl J Med 1969;;281:1292-1293.
16 +
Charbeneau TD, Hurt WC:  Gingival findings in spontaneous scurvy: A case report . J Periodontol 1983;;54:694-697.
17 +
Vilter RW, Woolford RM, Spies TD:  Severe scurvy: A clinical and hematologic study . J Lab Clin Med 1946;;31:609-630.
18 +
Goldberg A:  The anemia of scurvy . Q J Med 1963;;32:51-64.
19 +
Cox EV:  The anemia of scurvy . Vitam Horm 1968;;26:635-652.
20 +
Roeser HP:  The role of ascorbic acid in the turnover of storage iron . Semin Hematol 1983;; 20:91-100.
21 +
Stokes PL, Melikian V, Leeming RL, et al:  Folate metabolism in scurvy . Am J Clin Nutr 1975;;28:126-129.
22 +
Follis RH:  Sudden death in infants with scurvy . J Pediatr 1942;;20:347-351.
23 +
Abboud FM, Hood J, Hodges RE, et al:  Autonomic reflexes and vascular reactivity in experimental scurvy in man . J Clin Invest 1970;; 49:298-307.
24 +
Minor RR:  Collagen metabolism: A comparison of diseases of collagen and diseases affecting collagen . Am J Pathol 1980;;98:227-279.
25 +
Chojkier M, Spanheimer R, Peterkofsky B:  Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss: In vitro studies in guinea pig calvarial bones . J Clin Invest 1983;;72:826-835.
26 +
Sauberlich HE:  Vitamin C status: Methods and findings . Ann NY Acad Sci 1975;;258:438-450.
27 +
Hiebert CA:  Gastroesophageal reflux and ascorbic acid deficiency . Ann Thoracic Surg 1977;;24:108-112.
28 +
Sullivan JF, Eisenstein AB, Mottola OM, et al:  The effect of dialysis on plasma and tissue levels of vitamin C . Trans Am Soc Artif Intern Organs 1972;;18:277-282.
29 +
DeBari VA, Frank O, Baker H, et al:  Water soluble vitamins in granulocytes, erythrocytes, and plasma obtained from chronic hemodialysis patients . Am J Clin Nutr 1984;;39:410-415.

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