0
June 14, 1985, Vol 253, No. 22 >
ARTICLE | June 14, 1985

M-Mode and Two-dimensional Echocardiographic Abnormalities in Systemic Lupus Erythematosus FREE

Alice V. Klinkhoff, MD; Christopher R. Thompson, MD; Graham D. Reid, MB; Charles W. Tomlinson, MD, PhD
[+] Author Affiliations

Reprint requests to Cardiac Ultrasound Department, Vancouver General Hospital, Laurel Pavilion, 920 W Tenth Ave, Vancouver, British Columbia V5Z 1L8, Canada (Dr Tomlinson).


JAMA. 1985;253(22):3273-3277. doi:10.1001/jama.1985.03350460073024
Text Size: A A A
Published online
Article
References

A prospective clinical and echocardiographic study of 47 patients with systemic lupus erythematosus (SLE) and 46 age- and sex-matched controls showed an increased prevalence of echocardiographic abnormalities in the SLE group. Pericardial abnormalities were identified in ten patients with SLE and in no controls. Excluding mitral valve prolapse, valvular abnormalities were identified in ten patients with SLE (21%) and in three controls (7%). In the patients with SLE, abnormalities included mitral valve leaflet thickening in six, aortic valve thickening in five, and mitral annular calcification in two. The presence of valvular abnormalities correlated with duration but not with severity of SLE. The finding of systolic murmurs in 17 of 47 patients with SLE did not correlate with echocardiographic evidence of valvular disease. In six patients with SLE, valvular abnormalities detected by two-dimensional echocardiography were not seen on M-mode echocardiogram.

(JAMA 1985;253:3273-3277)

REFERENCES

1 +
Libman E, Sacks B:  A hitherto undescribed form of valvular and mural endocarditis . Arch Intern Med 1924;;33:701-737.
2 +
Harvey AM, Shulman LE, Tumulty PA, et al:  Systemic lupus erythematosus: A review of the literature and clinical analysis of 138 cases . Medicine 1954;;33:291-431.
3 +
Hejtmancik MR, Wright JC, Quint R, et al:  The cardiovascular manifestations of systemic lupus erythematosus . Am Heart J 1964;;68:119-130.
4 +
Shearn MA:  The heart in systemic lupus erythematosus . Am Heart J 1959;;58:452-466.
5 +
Gross L:  The cardiac lesion in Libman-Sacks disease with a consideration of its relationship to acute diffuse lupus erythematosus . Am J Pathol 1940;;16:375-407.
6 +
Baehr G, Klemperer P, Shifrin A:  A diffuse disease of the peripheral circulation (usually associated with lupus erythematosus and endocarditis) . Trans Assoc Am Phys 1935;;50:139-155.
7 +
Klemperer P, Pollack AD, Baehr G:  Pathology of disseminated lupus erythematosus . Arch Pathol 1941;;32:569-631.
8 +
Brigden W, Bywaters EG, Lessof MH:  The heart in systemic lupus erythematosus . Br Heart J 1960;;22:1-16.
9 +
Bulkley BH, Roberts WC:  The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy . Am J Med 1975;;58:243-264.
10 +
Maniscalo BS, Felner JM, McCans JL, et al:  Echocardiographic abnormalities in systemic lupus erythematosus , abstracted. Circulation 1975;;52( (suppl 2) ):211.
11 +
Elkayam U, Weiss S, Laniado S:  Pericardial effusion and mitral valve involvement in systemic lupus erythematosus . Ann Rheum Dis 1977;;36:349-353.
12 +
Collins RL, Turner RA, Nomeir AM, et al:  Cardiopulmonary manifestations of systemic lupus erythematosus . J Rheumatol 1978;;5:299-306.
13 +
Ito M, Kagiyama Y, Omura I, et al:  Cardiovascular manifestations in systemic lupus erythematosus . Jpn Circ J 1979;;43:985-994.
14 +
Chia BL, Mah EP, Feng PH:  Cardiovascular abnormalities in systemic lupus erythematosus . J Clin Ultrasound 1981;;9:237-243.
15 +
Lehman J, Palmer ST, Hastings C, et al:  Bacterial endocarditis complicating systemic lupus erythematosus . J Rheumatol 1933;;10:655-658.
16 +
Tan EM, Cohen AS, Fries JF, et al:  The 1982 revised criteria for the classification of systemic lupus erythematosus . Arthritis Rheum 1982;;25:1271-1277.
17 +
Sahn DJ, DeMaria A, Kisslo J, et al:  Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements . Circulation 1978;;58:1072-1083.
18 +
Shulman HJ, Christian CL:  Aortic insufficiency in systemic lupus erythematosus . Arthritis Rheum 1969;;12:138-146.
19 +
Pritzker MR, Ernst JD, Caudill C, et al:  Acquired aortic stenosis in systemic lupus erythematosus . Ann Intern Med 1980;;93:434-436.
20 +
Vaughton KC, Walker DR, Sturridge MF:  Mitral valve replacement for mitral stenosis caused by Libman-Sacks endocarditis . Br Heart J 1979;;41:730-733.
21 +
Paget SA, Bulkley BH, Grauer LE, et al:  Mitral valve disease of systemic lupus erythematosus: A cause of severe congestive heart failure reversed by valve replacement . Am J Med 1975;; 59:134-139.
22 +
Bulkley BH, Roberts WC:  Systemic lupus erythematosus as a cause of severe mitral regurgitation: New problems in an old disease . Am J Cardiol 1975;;35:305-308.
23 +
Rawsthorne L, Ptacin MJ, Choi H, et al:  Lupus valvulitis necessitating double valve replacement . Arthritis Rheum 1981;;24:561-564.
24 +
Murray FT, Fuleihan DS, Cornwall CS, et al:  Acute mitral regurgitation from ruptured chordae tendinae in systemic lupus erythematosus . J Rheumatol 1975;;2:454-459.
25 +
Lerman BB, Thomas LC, Abrams GD, et al:  Aortic stenosis associated with systemic lupus erythematosus . Am J Med 1982;;72:707-710.
26 +
Fox KS, Spence AM, Wheelis RF, et al:  Cerebral embolism in Libman-Sacks endocarditis . Neurology 1980;;30:487-491.
27 +
Dajee H, Hurley EJ, Szarnicki RJ:  Cardiac valve replacement in systemic lupus erythematosus . J Thorac Cardiovasc Surg 1983;;85:718-726.
28 +
Brennan FJ, Ford SE, Ford PM, et al:  Mitral regurgitation due to lupus endocarditis treated with valve replacement . Can Med Assoc J 1983;;129:584-587.
29 +
Bomalski J, Talano JV, Perlman S:  New heart murmur and fever in a patient with systemic lupus erythematosus . Arch Intern Med 1982;;122:823-824.
30 +
Dubois EL: Lupus Erythematosus: A Review of the Current Status of Discoid and Systemic Lupus Erythematosus , ed 2. Los Angeles, University of Southern California Press, 1974;.
31 +
Chang RW:  Cardiac manifestations of SLE . Clin Rheum Dis 1982;;8:197-206.
32 +
Urowitz MB, Bookman AAM, Koehler BE, et al:  The biomodal mortality pattern of systemic lupus erythematosus . Am J Med 1976;; 60:221-225.
33 +
Rosner S, Ginzler EM, Diamond HS, et al:  A multicenter study of outcome in systemic lupus erythematosus . Arthritis Rheum 1982;; 25:612-617.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Libman E, Sacks B:  A hitherto undescribed form of valvular and mural endocarditis . Arch Intern Med 1924;;33:701-737.
2 +
Harvey AM, Shulman LE, Tumulty PA, et al:  Systemic lupus erythematosus: A review of the literature and clinical analysis of 138 cases . Medicine 1954;;33:291-431.
3 +
Hejtmancik MR, Wright JC, Quint R, et al:  The cardiovascular manifestations of systemic lupus erythematosus . Am Heart J 1964;;68:119-130.
4 +
Shearn MA:  The heart in systemic lupus erythematosus . Am Heart J 1959;;58:452-466.
5 +
Gross L:  The cardiac lesion in Libman-Sacks disease with a consideration of its relationship to acute diffuse lupus erythematosus . Am J Pathol 1940;;16:375-407.
6 +
Baehr G, Klemperer P, Shifrin A:  A diffuse disease of the peripheral circulation (usually associated with lupus erythematosus and endocarditis) . Trans Assoc Am Phys 1935;;50:139-155.
7 +
Klemperer P, Pollack AD, Baehr G:  Pathology of disseminated lupus erythematosus . Arch Pathol 1941;;32:569-631.
8 +
Brigden W, Bywaters EG, Lessof MH:  The heart in systemic lupus erythematosus . Br Heart J 1960;;22:1-16.
9 +
Bulkley BH, Roberts WC:  The heart in systemic lupus erythematosus and the changes induced in it by corticosteroid therapy . Am J Med 1975;;58:243-264.
10 +
Maniscalo BS, Felner JM, McCans JL, et al:  Echocardiographic abnormalities in systemic lupus erythematosus , abstracted. Circulation 1975;;52( (suppl 2) ):211.
11 +
Elkayam U, Weiss S, Laniado S:  Pericardial effusion and mitral valve involvement in systemic lupus erythematosus . Ann Rheum Dis 1977;;36:349-353.
12 +
Collins RL, Turner RA, Nomeir AM, et al:  Cardiopulmonary manifestations of systemic lupus erythematosus . J Rheumatol 1978;;5:299-306.
13 +
Ito M, Kagiyama Y, Omura I, et al:  Cardiovascular manifestations in systemic lupus erythematosus . Jpn Circ J 1979;;43:985-994.
14 +
Chia BL, Mah EP, Feng PH:  Cardiovascular abnormalities in systemic lupus erythematosus . J Clin Ultrasound 1981;;9:237-243.
15 +
Lehman J, Palmer ST, Hastings C, et al:  Bacterial endocarditis complicating systemic lupus erythematosus . J Rheumatol 1933;;10:655-658.
16 +
Tan EM, Cohen AS, Fries JF, et al:  The 1982 revised criteria for the classification of systemic lupus erythematosus . Arthritis Rheum 1982;;25:1271-1277.
17 +
Sahn DJ, DeMaria A, Kisslo J, et al:  Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements . Circulation 1978;;58:1072-1083.
18 +
Shulman HJ, Christian CL:  Aortic insufficiency in systemic lupus erythematosus . Arthritis Rheum 1969;;12:138-146.
19 +
Pritzker MR, Ernst JD, Caudill C, et al:  Acquired aortic stenosis in systemic lupus erythematosus . Ann Intern Med 1980;;93:434-436.
20 +
Vaughton KC, Walker DR, Sturridge MF:  Mitral valve replacement for mitral stenosis caused by Libman-Sacks endocarditis . Br Heart J 1979;;41:730-733.
21 +
Paget SA, Bulkley BH, Grauer LE, et al:  Mitral valve disease of systemic lupus erythematosus: A cause of severe congestive heart failure reversed by valve replacement . Am J Med 1975;; 59:134-139.
22 +
Bulkley BH, Roberts WC:  Systemic lupus erythematosus as a cause of severe mitral regurgitation: New problems in an old disease . Am J Cardiol 1975;;35:305-308.
23 +
Rawsthorne L, Ptacin MJ, Choi H, et al:  Lupus valvulitis necessitating double valve replacement . Arthritis Rheum 1981;;24:561-564.
24 +
Murray FT, Fuleihan DS, Cornwall CS, et al:  Acute mitral regurgitation from ruptured chordae tendinae in systemic lupus erythematosus . J Rheumatol 1975;;2:454-459.
25 +
Lerman BB, Thomas LC, Abrams GD, et al:  Aortic stenosis associated with systemic lupus erythematosus . Am J Med 1982;;72:707-710.
26 +
Fox KS, Spence AM, Wheelis RF, et al:  Cerebral embolism in Libman-Sacks endocarditis . Neurology 1980;;30:487-491.
27 +
Dajee H, Hurley EJ, Szarnicki RJ:  Cardiac valve replacement in systemic lupus erythematosus . J Thorac Cardiovasc Surg 1983;;85:718-726.
28 +
Brennan FJ, Ford SE, Ford PM, et al:  Mitral regurgitation due to lupus endocarditis treated with valve replacement . Can Med Assoc J 1983;;129:584-587.
29 +
Bomalski J, Talano JV, Perlman S:  New heart murmur and fever in a patient with systemic lupus erythematosus . Arch Intern Med 1982;;122:823-824.
30 +
Dubois EL: Lupus Erythematosus: A Review of the Current Status of Discoid and Systemic Lupus Erythematosus , ed 2. Los Angeles, University of Southern California Press, 1974;.
31 +
Chang RW:  Cardiac manifestations of SLE . Clin Rheum Dis 1982;;8:197-206.
32 +
Urowitz MB, Bookman AAM, Koehler BE, et al:  The biomodal mortality pattern of systemic lupus erythematosus . Am J Med 1976;; 60:221-225.
33 +
Rosner S, Ginzler EM, Diamond HS, et al:  A multicenter study of outcome in systemic lupus erythematosus . Arthritis Rheum 1982;; 25:612-617.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems