0
April 19, 1985, Vol 253, No. 15 >
ARTICLE | April 19, 1985

Development and Early Natural History of HTLV-III Antibodies in Persons With Hemophilia FREE

M. Elaine Eyster, MD; James J. Goedert, MD; M. G. Sarngadharan, PhD; Stanley H. Weiss, MD; Robert C. Gallo, MD; William A. Blattner, MD
[+] Author Affiliations

Reprint requests to The Milton S. Hershey Medical Center, PO Box 850, Hershey, PA 17033 (Dr Eyster).


JAMA. 1985;253(15):2219-2223. doi:10.1001/jama.1985.03350390061026
Text Size: A A A
Published online
Article
References

Antibodies to human T-cell lymphotropic virus type III (HTLV-III) were first detected in 1979 in serum samples from 30 known seropositive patients with hemophilia, over half of whom seroconverted in 1981-1982. Lymphadenopathy was present in 70% who were seropositive more than three years, compared with 10% who were seropositive three years or less. T-helper cell counts were low (307 ± 64 cells/cu mm) in the early seroconverters, and normal in the late seroconverters. T-suppressor cell counts were not related to the year of seroconversion. The long latency period after seroconversion suggests an ongoing indolent process, rather than an acute infection. It remains to be determined whether this is an aberrant part of the immune response initiated by HTLV-III antigens or the result of a chronic active HTLV-III infection.

(JAMA 1985;253:2219-2223)

REFERENCES

1 +
Popovic M, Sarngadharan MG, Read E, et al:  Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS . Science 1984;; 224:497-500.
2 +
Gallo RC, Salahuddin SZ, Popovic M, et al:  Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS . Science 1984;; 224:500-503.
3 +
Montagnier L, Chermann JC, Barré-Sinoussi F, et al:  A new human T-lymphotrophic retrovirus: Characterization and possible role in lymphadenopathy and acquired immune deficiency syndrome , in Gallo RC, Essex ME, Gross OL (eds): Human T-Cell Leukemia Lymphoma Virus . New York, Cold Spring Harbor Laboratory, 1984;, pp 363-379.
4 +
Schupbach J, Popovic M, Gilden RV, et al:  Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated wth AIDS . Science 1984;;503-505.
5 +
Sarngadharan MG, Popovic M, Bruch L, et al:  Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS . Science 1984;;224:506-508.
6 +
Weiss SH, Goedert JJ, Sarngadharan MG, et al:  Screening test for HTLV-III (AIDS agent) antibodies: Specificity, sensitivity, and applications . JAMA 1985;;253:221-225.
7 +
Brun-Vezinet F, Rouzioux C, Barré-Sinoussi F, et al:  Detection of IgG antibodies of lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome . Lancet 1984;; 1:1253-1256.
8 +
Melbye M, Biggar RJ, Ebbesen P, et al:  Seroepidemiology of HTLV-III (AIDS-agent) antibody in European homosexual men: Prevalence, transmission, and disease outcome . Br Med J 1984;;289:573-575.
9 +
Goedert JJ, Sarngadharan MG, Biggar RJ, et al:  Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men . Lancet 1984;;2:711-716.
10 +
 Update: Acquired immune deficiency syndrome (AIDS) among patients with hemophilia in United States . MMWR 1984;;33:589-591.
11 +
Melbye M, Biggar RJ, Chermann JC, et al:  High prevalence of lymphadenopathy virus (LAV) in European hemophiliacs . Lancet 1984;; 2:40-41.
12 +
Ramsey RB, Palmer EL, McDougal JS, et al:  Antibody to lymphadenopathy associated virus in hemophiliacs with and without AIDS . Lancet 1984;;2:397-398.
13 +
Goedert JJ, Sarngadharan MG, Eyster ME, et al:  Antibodies reactive with human T-cell leukemia viruses (HTLV-III) in the sera of hemophiliacs receiving factor VIII concentrate . Blood 1985;;65:492-495.
14 +
Curran JW:  AIDS—two years later . N Engl J Med 1983;;309:609-611.
15 +
Jaffe HW, Choi K, Thomas PA, et al:  National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: I. Epidemiologic results . Ann Intern Med 1983;;99:145-151.
16 +
Rogers MF, Morens DM, Stewart JA, et al:  National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: II: Laboratory results . Ann Intern Med 1983;;99:151-158.
17 +
Ammann AJ, Wara DW, Dritz S, et al:  Acquired immunodeficiency in an infant: Possible transmission by means of blood products . Lancet 1983;;1:956-958.
18 +
Curran JW, Lawrence DN, Jaffe HJ, et al:  Acquired immunodeficiency syndrome (AIDS) associated with transfusions . N Engl J Med 1984;;310:69-75.
19 +
Mantel N:  Chi-square tests with one degree of freedom: Extension of the Mantel-Haenszel procedure . J Am Stat Assoc 1963;; 58:690-700.
20 +
Draper NR, Smith H: Applied Regression Analysis . New York, John Wiley & Sons Inc, 1966;.
21 +
Saxinger C, Gallo RC:  Methods in laboratory investigation: Application of the indirect enzyme-lined immunosorbent assay microtest to the detection and surveillance of human T-cell leukemia-lymphoma virus . Lab Invest 1983;; 49:371-377.
22 +
Eyster ME, Goedert JJ, Poon M-C, et al:  Acid-labile alpha interferon: A possible preclinical marker for the acquired immunodeficiency syndrome in hemophilia . N Engl J Med 1983;; 309:583-586.
23 +
Goedert JJ, Biggar RJ, Winn DM, et al:  Determinants of lesser AIDS , abstracted. Proc Am Soc Clin Oncol 1984;;3:14.
24 +
Gill JC, Menitove JE, Wheeler D, et al:  Generalized lymphadenopathy and T-cell abnormalities in hemophilia A . J Pediatric 1983;; 103:18-22.
25 +
Andes WA, DeShazo RD, Reed RJ, et al:  Studies of lymph nodes from patients with classical hemophilia . Blood 1984;;64:768-773.
26 +
Lederman MM, Ratnoff OD, Scillian JJ, et al:  Impaired cell-mediated immunity in patients with classic hemophilia . N Engl J Med 1983;; 308:79-83.
27 +
Menitove JE, Aster RH, Caspe JT, et al:  T lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophylized concentrates . N Engl J Med 1983;;308:83-86.
28 +
Eyster ME, Whithurst DA, Catalano PM, et al:  Long term follow-up of hemophiliacs with lymphocytopenia or thrombocytopenia , abstracted. Blood 1984;;64:95.
29 +
Kitchen LW, Barin F, Sullivan JL, et al:  Aetiology of AIDS: Antibodies to human T-cell leukaemia virus (type III) in haemophiliacs . Nature 1984;;312:367-369.
30 +
Evatt BL, Gomperts ED, McDougal JS, et al:  Coincidental appearance of LAV I HTLV III antibodies in hemophiliacs and the onset of the AIDS epidemic . N Engl J Med 1985;;312: 483-486.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Popovic M, Sarngadharan MG, Read E, et al:  Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS . Science 1984;; 224:497-500.
2 +
Gallo RC, Salahuddin SZ, Popovic M, et al:  Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS . Science 1984;; 224:500-503.
3 +
Montagnier L, Chermann JC, Barré-Sinoussi F, et al:  A new human T-lymphotrophic retrovirus: Characterization and possible role in lymphadenopathy and acquired immune deficiency syndrome , in Gallo RC, Essex ME, Gross OL (eds): Human T-Cell Leukemia Lymphoma Virus . New York, Cold Spring Harbor Laboratory, 1984;, pp 363-379.
4 +
Schupbach J, Popovic M, Gilden RV, et al:  Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated wth AIDS . Science 1984;;503-505.
5 +
Sarngadharan MG, Popovic M, Bruch L, et al:  Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS . Science 1984;;224:506-508.
6 +
Weiss SH, Goedert JJ, Sarngadharan MG, et al:  Screening test for HTLV-III (AIDS agent) antibodies: Specificity, sensitivity, and applications . JAMA 1985;;253:221-225.
7 +
Brun-Vezinet F, Rouzioux C, Barré-Sinoussi F, et al:  Detection of IgG antibodies of lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome . Lancet 1984;; 1:1253-1256.
8 +
Melbye M, Biggar RJ, Ebbesen P, et al:  Seroepidemiology of HTLV-III (AIDS-agent) antibody in European homosexual men: Prevalence, transmission, and disease outcome . Br Med J 1984;;289:573-575.
9 +
Goedert JJ, Sarngadharan MG, Biggar RJ, et al:  Determinants of retrovirus (HTLV-III) antibody and immunodeficiency conditions in homosexual men . Lancet 1984;;2:711-716.
10 +
 Update: Acquired immune deficiency syndrome (AIDS) among patients with hemophilia in United States . MMWR 1984;;33:589-591.
11 +
Melbye M, Biggar RJ, Chermann JC, et al:  High prevalence of lymphadenopathy virus (LAV) in European hemophiliacs . Lancet 1984;; 2:40-41.
12 +
Ramsey RB, Palmer EL, McDougal JS, et al:  Antibody to lymphadenopathy associated virus in hemophiliacs with and without AIDS . Lancet 1984;;2:397-398.
13 +
Goedert JJ, Sarngadharan MG, Eyster ME, et al:  Antibodies reactive with human T-cell leukemia viruses (HTLV-III) in the sera of hemophiliacs receiving factor VIII concentrate . Blood 1985;;65:492-495.
14 +
Curran JW:  AIDS—two years later . N Engl J Med 1983;;309:609-611.
15 +
Jaffe HW, Choi K, Thomas PA, et al:  National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: I. Epidemiologic results . Ann Intern Med 1983;;99:145-151.
16 +
Rogers MF, Morens DM, Stewart JA, et al:  National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: II: Laboratory results . Ann Intern Med 1983;;99:151-158.
17 +
Ammann AJ, Wara DW, Dritz S, et al:  Acquired immunodeficiency in an infant: Possible transmission by means of blood products . Lancet 1983;;1:956-958.
18 +
Curran JW, Lawrence DN, Jaffe HJ, et al:  Acquired immunodeficiency syndrome (AIDS) associated with transfusions . N Engl J Med 1984;;310:69-75.
19 +
Mantel N:  Chi-square tests with one degree of freedom: Extension of the Mantel-Haenszel procedure . J Am Stat Assoc 1963;; 58:690-700.
20 +
Draper NR, Smith H: Applied Regression Analysis . New York, John Wiley & Sons Inc, 1966;.
21 +
Saxinger C, Gallo RC:  Methods in laboratory investigation: Application of the indirect enzyme-lined immunosorbent assay microtest to the detection and surveillance of human T-cell leukemia-lymphoma virus . Lab Invest 1983;; 49:371-377.
22 +
Eyster ME, Goedert JJ, Poon M-C, et al:  Acid-labile alpha interferon: A possible preclinical marker for the acquired immunodeficiency syndrome in hemophilia . N Engl J Med 1983;; 309:583-586.
23 +
Goedert JJ, Biggar RJ, Winn DM, et al:  Determinants of lesser AIDS , abstracted. Proc Am Soc Clin Oncol 1984;;3:14.
24 +
Gill JC, Menitove JE, Wheeler D, et al:  Generalized lymphadenopathy and T-cell abnormalities in hemophilia A . J Pediatric 1983;; 103:18-22.
25 +
Andes WA, DeShazo RD, Reed RJ, et al:  Studies of lymph nodes from patients with classical hemophilia . Blood 1984;;64:768-773.
26 +
Lederman MM, Ratnoff OD, Scillian JJ, et al:  Impaired cell-mediated immunity in patients with classic hemophilia . N Engl J Med 1983;; 308:79-83.
27 +
Menitove JE, Aster RH, Caspe JT, et al:  T lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophylized concentrates . N Engl J Med 1983;;308:83-86.
28 +
Eyster ME, Whithurst DA, Catalano PM, et al:  Long term follow-up of hemophiliacs with lymphocytopenia or thrombocytopenia , abstracted. Blood 1984;;64:95.
29 +
Kitchen LW, Barin F, Sullivan JL, et al:  Aetiology of AIDS: Antibodies to human T-cell leukaemia virus (type III) in haemophiliacs . Nature 1984;;312:367-369.
30 +
Evatt BL, Gomperts ED, McDougal JS, et al:  Coincidental appearance of LAV I HTLV III antibodies in hemophiliacs and the onset of the AIDS epidemic . N Engl J Med 1985;;312: 483-486.

Letters

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems