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April 12, 1985, Vol 253, No. 14 >
ARTICLE | April 12, 1985

Effective Medical Treatment for Hydatid Disease? FREE

Peter M. Schantz, DVM, PhD
JAMA. 1985;253(14):2095-2097. doi:10.1001/jama.1985.03350380111033
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References

Until recently, treatment of hydatid disease (larval echinococcosis) has been in the hands of surgeons, and there has been little to offer patients with nonresectable lesions or those who could not tolerate surgery. However, recent experience with several benzimidazole drugs suggests that chemotherapy may be an important adjunct to surgery or, in certain circumstances, replace surgery as the therapy of choice. In this issue of The Journal, Motris and colleagues' describe their experience with albendazole, which of all the benzimidazoles tested so far, may hold the most potential.

How much hydatid disease occurs in the United States? Cystic hydatid disease (CHD) is acquired when human beings ingest eggs of the dog-host tapeworm Echinococcus granulosus. The larval cysts typically occur in the liver and lungs or, less commonly, in othet organs. In the contiguous United States, locally acquired CHD is rare and strictly limited geographically; transmission is known to occur between dogs and sheep in

REFERENCES

1 +
Morris DL, Dykes PW, Marriner S, et al:  Albendazole—objective evidence of response in human hydatid disease . JAMA 1985;;253:2053-2057.
2 +
Crellin JR, Andersen FC, Schantz PM, et al:  Possible factors influencing distribution and prevalence of Echinococcus granulosus in Utah . Am J Epidemiol 1982;;116:463-474.
3 +
Araujo PF, Schwabe CW, Sawyer JC, et al:  Hydatid disease transmission in California: A study of the Basque connection . Am J Epidemiol 1975;;102:291-302.
4 +
Schantz PM:  Echinococcosis in American Indians living in Arizona and New Mexico: A review of recent studies . Am J Epidemiol 1977;;106:370-379.
5 +
Pappaioanou M, Schwabe CW, Sard DM:  An evolving pattern of human hydatid disease transmission in the United States . Am J Trop Med Hyg 1977;;26:732-742.
6 +
Daly JJ, McDaniel RC, Husted GS, et al:  Unilocular hydatid cyst disease in the mid-South .JAMA 1984;;251:932-933.
7 +
Wilson JF, Diddams AC, Rausch RL:  Cystic hydatid disease in Alaska: A review of 101 autochthonous cases of Echinococcus granulosus infection . Am Rev Respir Dis 1968;;98:1-15.
8 +
Schantz PM:  Echinococcosis , in Arambulo P, Jacobs L (eds): CRC Handbook Series of Zoonoses , section C, parasitic zoonoses. Boca Raton, Fla, CRC Press Inc, 1983;, vol 1, pp 231-237.
9 +
Schantz PM, Williams JF, Riva Posse C:  The epidemiology of hydatid disease in southern Argentina: Comparison of morbidity indices, evaluation of immunodiagnostic tests and factors affecting transmission in southern Rio Negra province . Am J Trop Med Hyg 1973;;22:629-636.
10 +
Purriel P. Schantz PM, Beovide H, et al:  Human echinococcosis (hydatidosis) in Uruguay: A comparison of indices of morbidity and mortality, 1962-71 . Bull WHO 1973;;49:395-402.
11 +
French CM. Nelson GS:  Hydatid disease in the Turkana district of Kenya: A study in medical geography . Ann Trop Med Parasitol 1982;;76:439-457.
12 +
Katz AM. Pan CT:  Echinococcus disease in the United States . Am J Med 1958;;25:759-770.
13 +
Amir-Jahed AK, Fardin R, Farzad A, et al:  Clinical echinococcosis . Ann Surg 1975;;182:541-546.
14 +
Wilson JF, Rausch RL:  Alveolar hydatid disease: A review of clinical features of 33 indigenous cases of Echinococcus multilocularis infection in Alaskan Eskimos . Am J Trop Med Hyg 1980;;29:1340-1355.
15 +
Gamble WG, Segal M. Schantz PM, et al:  Alveolar hydatid disease in Minnesota: First human case acquired in the contiguous United States . JAMA 1979;;241:904-906.
16 +
Mossiman F:  Is alveolar hydatid disease of the liver incurable? Ann Surg 1980;;192:118-123.
17 +
Schantz PM, Van den Bossche H, Eckert J:  Chemotherapy for larval echinococcosis in animals and humans: Report of a workshop . Z Parasitenkd 1982;;67:5-26.
18 +
Braithwaite PA:  Long-term high-dose mebendazole for cystic hydatid disease of liver: Failure in two cases . Aust NZ J Surg 1981;;51:23-27.
19 +
Bryceson ADM, Cowie AGA, Macleod C, et al:  Experience with mebendazole in the treatment of inoperable hydatid disease in England . Trans R Soc Trop Med Hyg 1982;;76:510-518.
20 +
Muller E, Akovbiantz A, Ammann RW, et al:  Treatment of human echinococcosis with mebendazole: Preliminary observations in 28 patients . Hepatogastroenterology 1982;;29:236-239.
21 +
Kern P:  Human echinococcosis: Followup of 23 patients treated with mebendazole . Infection 1983;;11:17-24.
22 +
Kammerer WS, Schantz PM:  Long term followup of human hydatid disease (Echinococcus granulosus) treated with a high dose mebendazole regimen . Am J Trop Med Hyg 1984;;33:132-137.
23 +
Braithwaite PA:  Medical treatment for hydatid disease . Proc R Coll Surg , in press.
24 +
Saimot AG, Meulemans A, Grimieux AC, et al:  Albendazole as a potential treatment for human hydatidosis . Lancet 1983;;2:652-656.
25 +
Levin MIL Weinstein RA, Axelrod JL, et al:  Severe, reversible neutropenia during high-dose mebendazole for echinococcosis . JAMA 1983;;249:2929-2931.
26 +
Stallbaumer MF, Morris DL, Clarkson MJ. et al:  Albendazole treatment of pulmonary hydatid disease in a sheep model . Thorax , in press.
27 +
Treatment of Human Echinococcosis . Report of an informal World Health Organization meeting. Geneva, Parasitic Diseases Program 82.1, 1981;, pp 1-44.

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1 +
Morris DL, Dykes PW, Marriner S, et al:  Albendazole—objective evidence of response in human hydatid disease . JAMA 1985;;253:2053-2057.
2 +
Crellin JR, Andersen FC, Schantz PM, et al:  Possible factors influencing distribution and prevalence of Echinococcus granulosus in Utah . Am J Epidemiol 1982;;116:463-474.
3 +
Araujo PF, Schwabe CW, Sawyer JC, et al:  Hydatid disease transmission in California: A study of the Basque connection . Am J Epidemiol 1975;;102:291-302.
4 +
Schantz PM:  Echinococcosis in American Indians living in Arizona and New Mexico: A review of recent studies . Am J Epidemiol 1977;;106:370-379.
5 +
Pappaioanou M, Schwabe CW, Sard DM:  An evolving pattern of human hydatid disease transmission in the United States . Am J Trop Med Hyg 1977;;26:732-742.
6 +
Daly JJ, McDaniel RC, Husted GS, et al:  Unilocular hydatid cyst disease in the mid-South .JAMA 1984;;251:932-933.
7 +
Wilson JF, Diddams AC, Rausch RL:  Cystic hydatid disease in Alaska: A review of 101 autochthonous cases of Echinococcus granulosus infection . Am Rev Respir Dis 1968;;98:1-15.
8 +
Schantz PM:  Echinococcosis , in Arambulo P, Jacobs L (eds): CRC Handbook Series of Zoonoses , section C, parasitic zoonoses. Boca Raton, Fla, CRC Press Inc, 1983;, vol 1, pp 231-237.
9 +
Schantz PM, Williams JF, Riva Posse C:  The epidemiology of hydatid disease in southern Argentina: Comparison of morbidity indices, evaluation of immunodiagnostic tests and factors affecting transmission in southern Rio Negra province . Am J Trop Med Hyg 1973;;22:629-636.
10 +
Purriel P. Schantz PM, Beovide H, et al:  Human echinococcosis (hydatidosis) in Uruguay: A comparison of indices of morbidity and mortality, 1962-71 . Bull WHO 1973;;49:395-402.
11 +
French CM. Nelson GS:  Hydatid disease in the Turkana district of Kenya: A study in medical geography . Ann Trop Med Parasitol 1982;;76:439-457.
12 +
Katz AM. Pan CT:  Echinococcus disease in the United States . Am J Med 1958;;25:759-770.
13 +
Amir-Jahed AK, Fardin R, Farzad A, et al:  Clinical echinococcosis . Ann Surg 1975;;182:541-546.
14 +
Wilson JF, Rausch RL:  Alveolar hydatid disease: A review of clinical features of 33 indigenous cases of Echinococcus multilocularis infection in Alaskan Eskimos . Am J Trop Med Hyg 1980;;29:1340-1355.
15 +
Gamble WG, Segal M. Schantz PM, et al:  Alveolar hydatid disease in Minnesota: First human case acquired in the contiguous United States . JAMA 1979;;241:904-906.
16 +
Mossiman F:  Is alveolar hydatid disease of the liver incurable? Ann Surg 1980;;192:118-123.
17 +
Schantz PM, Van den Bossche H, Eckert J:  Chemotherapy for larval echinococcosis in animals and humans: Report of a workshop . Z Parasitenkd 1982;;67:5-26.
18 +
Braithwaite PA:  Long-term high-dose mebendazole for cystic hydatid disease of liver: Failure in two cases . Aust NZ J Surg 1981;;51:23-27.
19 +
Bryceson ADM, Cowie AGA, Macleod C, et al:  Experience with mebendazole in the treatment of inoperable hydatid disease in England . Trans R Soc Trop Med Hyg 1982;;76:510-518.
20 +
Muller E, Akovbiantz A, Ammann RW, et al:  Treatment of human echinococcosis with mebendazole: Preliminary observations in 28 patients . Hepatogastroenterology 1982;;29:236-239.
21 +
Kern P:  Human echinococcosis: Followup of 23 patients treated with mebendazole . Infection 1983;;11:17-24.
22 +
Kammerer WS, Schantz PM:  Long term followup of human hydatid disease (Echinococcus granulosus) treated with a high dose mebendazole regimen . Am J Trop Med Hyg 1984;;33:132-137.
23 +
Braithwaite PA:  Medical treatment for hydatid disease . Proc R Coll Surg , in press.
24 +
Saimot AG, Meulemans A, Grimieux AC, et al:  Albendazole as a potential treatment for human hydatidosis . Lancet 1983;;2:652-656.
25 +
Levin MIL Weinstein RA, Axelrod JL, et al:  Severe, reversible neutropenia during high-dose mebendazole for echinococcosis . JAMA 1983;;249:2929-2931.
26 +
Stallbaumer MF, Morris DL, Clarkson MJ. et al:  Albendazole treatment of pulmonary hydatid disease in a sheep model . Thorax , in press.
27 +
Treatment of Human Echinococcosis . Report of an informal World Health Organization meeting. Geneva, Parasitic Diseases Program 82.1, 1981;, pp 1-44.

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