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April 12, 1985, Vol 253, No. 14 >
ARTICLE | April 12, 1985

Albendazole—Objective Evidence of Response in Human Hydatid Disease FREE

David L. Morris, MD; Peter W. Dykes, MD; Susan Marriner, PhD; James Bogan, PhD; Fred Burrows, FRCR; Hilary Skeene-Smith, FRCR; Michael J. Clarkson, MRCVS
JAMA. 1985;253(14):2053-2057. doi:10.1001/jama.1985.03350380069023
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References

Thirty-two patients with cysts caused by Echinococcus granulosus were treated with albendazole in a dosage of 10 mg/kg/day. Reversible abnormalities in liver-cell function tests were seen in five patients. Some radiological evidence of remission (on serial computed tomographic or ultrasound scanning) was seen in 15 of 22 patients undergoing a therapeutic course of albendazole (as opposed to those treated before or after surgery). In five patients, the cysts virtually disappeared. Apart from reduction in size, the appearance of a halo around the cysts and the apparent disappearance of daughter cysts has been seen. Serological findings have not correlated well with radiological or clinical improvement. Serum and cyst concentrations of albendazole sulfoxide (the principal metabolite) have been measured.

(JAMA 1985;253:2053-2057)

REFERENCES

1 +
Matossion RM, Rickard MD, Smyth JD:  Hydatidosis: A global problem of increasing importance . WHO Chron 1977;;55:499-507.
2 +
Matossion RM:  The immunological diagnosis of human hydatid disease . Trans R Soc Trop Med Hyg 1977;;71:101-110.
3 +
Niron EA, Ozer H:  Ultrasound appearance of liver hydatid disease . Br J Radiol 1981;; 54:335-338.
4 +
Alltree M:  Scanning in hydatid disease . Clin Radiol 1979;;30:691-697.
5 +
Barros JL:  Hydatid disease of the liver . Am J Surg 1978;;135:579-600.
6 +
Motaghion H, Saidi F:  Post operative recurrence of hydatid disease . Br J Surg 1978;;65:237-242.
7 +
Amir-Jahed AK, Fardin R, Farzad A, et al:  Clinical echinococcosis . Ann Surg 1975;;182:541-546.
8 +
Bekhti A, Schaaps JP, Capron M, et al:  Treatment of hepatic hydatid disease with mebendazole: Preliminary results on four cases . Br Med J 1977;;2:1047-1051.
9 +
Braithwaite PA:  Long-term high-dose mebendazole for cystic hydatid disease of the liver: Failure in two cases . Aust NZ J Surg 1981;; 51:23-27.
10 +
Morris DL, Gould S:  Serum and cyst concentrations of mebendazole and flubendazole in hydatid disease . Br Med J 1982;;285:175.
11 +
Bryceson ADM, Woestenborghs R, Michiels M, et al:  Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease . Trans R Soc Trop Med Hyg 1982;; 76:563-564.
12 +
Braithwaite PA, Roberts MS, Allan RJ, et al:  Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease . Eur J Clin Pharmacol 1982;; 22:161-169.
13 +
Marriner SE, Bogan JA:  Pharmacokinetics of albendazole in sheep . Am J Vet Res 1980;; 41:1126-1129.
14 +
Euzeby J:  Preventive and curative properties of albendazole on hepatic-peritoneal cystercosis in rabbits . Rev Med Vet 1981;;132:279-283.
15 +
Lloyd S, Soulsby EJL, Theorides VJ:  Effect of albendazole on the metacestodes of Taenia saginata in calves . Seperatum Experimentia 1978;;34:723-724.
16 +
Morris DL, Dykes PW, Dickson B, et al:  Albendazole in hydatid disease . Br Med J 1983;; 286:103-104.
17 +
Saimot AG, Meulemans A, Grimeux AC, Giovangeli MD, Hay JM, Delaitre B, Coulard JP:  Albendazole as a potential treatment for human hydatidosis . Lancet 1983;;2:652-656.
18 +
Bogan JA, Marriner SE:  Analysis of benzimidazoles in body fluids by high performance liquid chromatography . J Pharm Sci 1980;; 69:422-423.
19 +
Smyth JD, Barrett NS:  Procedures for testing the visibility of human hydatid cysts following surgical removal, especially after chemotherapy . Trans R Soc Trop Med Hyg 1980;;74:649-652.
20 +
Morris DL, Clarkson MJ, Stallbaumer MF, et al:  Albendazole treatment of pulmonary hydatid disease in a sheep model . Thorax , in press.
21 +
Schantz PM, Van den Bossche H, Eckert J:  Chemotherapy for larval Echinococcus in animals and humans: Report of a workshop . Z Parasitenkd 1982;;67:5-26.
22 +
Mossiman F:  Is alveolar hydatid disease of the liver incurable? Ann Surg 1980;;192:118-123.

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1 +
Matossion RM, Rickard MD, Smyth JD:  Hydatidosis: A global problem of increasing importance . WHO Chron 1977;;55:499-507.
2 +
Matossion RM:  The immunological diagnosis of human hydatid disease . Trans R Soc Trop Med Hyg 1977;;71:101-110.
3 +
Niron EA, Ozer H:  Ultrasound appearance of liver hydatid disease . Br J Radiol 1981;; 54:335-338.
4 +
Alltree M:  Scanning in hydatid disease . Clin Radiol 1979;;30:691-697.
5 +
Barros JL:  Hydatid disease of the liver . Am J Surg 1978;;135:579-600.
6 +
Motaghion H, Saidi F:  Post operative recurrence of hydatid disease . Br J Surg 1978;;65:237-242.
7 +
Amir-Jahed AK, Fardin R, Farzad A, et al:  Clinical echinococcosis . Ann Surg 1975;;182:541-546.
8 +
Bekhti A, Schaaps JP, Capron M, et al:  Treatment of hepatic hydatid disease with mebendazole: Preliminary results on four cases . Br Med J 1977;;2:1047-1051.
9 +
Braithwaite PA:  Long-term high-dose mebendazole for cystic hydatid disease of the liver: Failure in two cases . Aust NZ J Surg 1981;; 51:23-27.
10 +
Morris DL, Gould S:  Serum and cyst concentrations of mebendazole and flubendazole in hydatid disease . Br Med J 1982;;285:175.
11 +
Bryceson ADM, Woestenborghs R, Michiels M, et al:  Bioavailability and tolerability of mebendazole in patients with inoperable hydatid disease . Trans R Soc Trop Med Hyg 1982;; 76:563-564.
12 +
Braithwaite PA, Roberts MS, Allan RJ, et al:  Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease . Eur J Clin Pharmacol 1982;; 22:161-169.
13 +
Marriner SE, Bogan JA:  Pharmacokinetics of albendazole in sheep . Am J Vet Res 1980;; 41:1126-1129.
14 +
Euzeby J:  Preventive and curative properties of albendazole on hepatic-peritoneal cystercosis in rabbits . Rev Med Vet 1981;;132:279-283.
15 +
Lloyd S, Soulsby EJL, Theorides VJ:  Effect of albendazole on the metacestodes of Taenia saginata in calves . Seperatum Experimentia 1978;;34:723-724.
16 +
Morris DL, Dykes PW, Dickson B, et al:  Albendazole in hydatid disease . Br Med J 1983;; 286:103-104.
17 +
Saimot AG, Meulemans A, Grimeux AC, Giovangeli MD, Hay JM, Delaitre B, Coulard JP:  Albendazole as a potential treatment for human hydatidosis . Lancet 1983;;2:652-656.
18 +
Bogan JA, Marriner SE:  Analysis of benzimidazoles in body fluids by high performance liquid chromatography . J Pharm Sci 1980;; 69:422-423.
19 +
Smyth JD, Barrett NS:  Procedures for testing the visibility of human hydatid cysts following surgical removal, especially after chemotherapy . Trans R Soc Trop Med Hyg 1980;;74:649-652.
20 +
Morris DL, Clarkson MJ, Stallbaumer MF, et al:  Albendazole treatment of pulmonary hydatid disease in a sheep model . Thorax , in press.
21 +
Schantz PM, Van den Bossche H, Eckert J:  Chemotherapy for larval Echinococcus in animals and humans: Report of a workshop . Z Parasitenkd 1982;;67:5-26.
22 +
Mossiman F:  Is alveolar hydatid disease of the liver incurable? Ann Surg 1980;;192:118-123.

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