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Vasectomy and Health: Title and subTitle BreakResults From a Large Cohort Study FREE

Frank J. Massey, Jr, PhD; Gerald S. Bernstein, PhD, MD; William M. O'Fallon, PhD; Leonard M. Schuman, MD, MS; Anne H. Coulson; Ruth Crozier, MA; Jack S. Mandel, PhD; Robert B. Benjamin, MD; Heinz W. Berendes, MD, MHS; Potter C. Chang, PhD; Roger Detels, MD, MS; Richard F. Emslander, MD; James Korelitz, PhD; Leonard T. Kurland, MD, DrPH; Irwin H. Lepow, MD, PhD; Douglas D. McGregor, MD, DPhil; Robert N. Nakamura, PhD; Jose Quiroga, MD; Stanwood Schmidt, MD; Gary H. Spivey, MD, MPH; Timothy Sullivan, MD
[+] Author Affiliations

Reprint requests to School of Public Health, University of California, Los Angeles, CA 90024 (Dr Massey).


JAMA. 1984;252(8):1023-1029. doi:10.1001/jama.1984.03350080025021
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In this historical cohort study we identified, located, and, if living, interviewed 10,590 vasectomized men from four cities, along with a paired neighborhood control for each. The times between procedure data and interview or death ranged from under one to 41 years, with median equal to 7.9 years and with 2,318 pairs having ten or more years of follow-up. Participant reports of diseases or conditions that might possibly be related to vasectomy through an immunopathological mechanism were validated by direct contact with physicians and review of medical records. Results of this study do not support the suggestions of immunopathological consequences of vasectomy within the period of follow-up. Except for epididymitis-orchitis, the incidence of diseases for vasectomized men was similar or lower than for their paired controls.

(JAMA 1984;252:1023-1029)

REFERENCES

Lepow IH, Crozier R (eds): Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man . New York, Academic Press Inc, 1979;.
Ansbacher R:  Humoral sperm antibodies: A ten-year follow-up of vas-ligated men . Fertil Steril 1981;;36:222-224.
Bigazzi PE, Kosuda LL, Hsu KC, et al:  Immune complex orchitis in vasectomized rabbits . J Exp Med 1976;;143:382-404.
Alexander NJ, Clarkson TB:  Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis . Science 1978;; 201:538-541.
Clarkson TB, Alexander NJ:  Long-term vasectomy: Effects on the occurrence and extent of atherosclerosis in rhesus monkeys . J Clin Invest 1980;;65:15-25.
Woolson RF, Lachenbruch PA:  Rank tests for censored matched pairs . Biometrika 1980;; 67:597-606.
Kalbfleisch JD, Prentiss RL: The Statistical Analysis of Failure Time Data . New York, John Wiley & Sons Inc, 1980;.
Robert HJ:  Delayed thrombophlebitis and systemic complications after vasectomy: Possible role of diabetogenic hyperinsulinism . J Am Geriatr Soc 1968;;16:267-280.
Winer J, quoted by Johnson DS:  Reversible male sterilization: Current status and future directions . Contraception 1972;;5:327-338.
Goldacre M, Vessey M, Clarke J, et al:  Record linkage study of morbidity following vasectomy , in Lepow IH, Crozier R (eds): Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man . New York, Academic Press Inc, 1979;, pp 567-575.
Walker AM, Jick H, Hunter JR, et al:  Hospitalization rates in vasectomized men . JAMA 1981;;245:2315-2317.
Petitti DB, Klein R, Kipp H, et al:  A survey of personal habits, symptoms of illness, and histories of disease in men with and without vasectomies . Am J Public Health 1982;;72:476-480.

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Lepow IH, Crozier R (eds): Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man . New York, Academic Press Inc, 1979;.
Ansbacher R:  Humoral sperm antibodies: A ten-year follow-up of vas-ligated men . Fertil Steril 1981;;36:222-224.
Bigazzi PE, Kosuda LL, Hsu KC, et al:  Immune complex orchitis in vasectomized rabbits . J Exp Med 1976;;143:382-404.
Alexander NJ, Clarkson TB:  Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis . Science 1978;; 201:538-541.
Clarkson TB, Alexander NJ:  Long-term vasectomy: Effects on the occurrence and extent of atherosclerosis in rhesus monkeys . J Clin Invest 1980;;65:15-25.
Woolson RF, Lachenbruch PA:  Rank tests for censored matched pairs . Biometrika 1980;; 67:597-606.
Kalbfleisch JD, Prentiss RL: The Statistical Analysis of Failure Time Data . New York, John Wiley & Sons Inc, 1980;.
Robert HJ:  Delayed thrombophlebitis and systemic complications after vasectomy: Possible role of diabetogenic hyperinsulinism . J Am Geriatr Soc 1968;;16:267-280.
Winer J, quoted by Johnson DS:  Reversible male sterilization: Current status and future directions . Contraception 1972;;5:327-338.
Goldacre M, Vessey M, Clarke J, et al:  Record linkage study of morbidity following vasectomy , in Lepow IH, Crozier R (eds): Vasectomy: Immunologic and Pathophysiologic Effects in Animals and Man . New York, Academic Press Inc, 1979;, pp 567-575.
Walker AM, Jick H, Hunter JR, et al:  Hospitalization rates in vasectomized men . JAMA 1981;;245:2315-2317.
Petitti DB, Klein R, Kipp H, et al:  A survey of personal habits, symptoms of illness, and histories of disease in men with and without vasectomies . Am J Public Health 1982;;72:476-480.
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