To the Editor.— A variety of reports of ultrastructural and immunopathologic changes in the renal glomerulus and of proteinuria and membranous glomerulonephritis have been related to the use of captopril. However, many of the abnormalities originally attributed to captopril have been found in the glomeruli of hypertensive persons who had never received this drug.1 The chemical structure of captopril has raised many suspicions with regard to potential side effects. There has been a tendency to equate the chemical structure of captopril with that of penicillamine, by virtue of their sulfhydryl groups, which has contributed greatly to the suspicions of toxicity surrounding the drug. However, with respect to possible glomerular damage, the safety profile of enalapril, an angiotensin-converting enzyme inhibitor that does not contain a sulfhydryl moiety, reveals that proteinuria occurs as frequently with that drug (1.4%) as it does among those treated with captopril (1.2%) and among hypertensive patients
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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