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August 10, 1984, Vol 252, No. 6 >
ARTICLE | August 10, 1984

Zinc Ingestion and Lipoprotein Values in Sedentary and Endurance-Trained Men FREE

Stephen F. Crouse, PhD; Philip L. Hooper, MD; Hemming A. Atterbom, PhD; Richard L. Papenfuss, PhD
[+] Author Affiliations

Reprint requests to Department of Health and Physical Education, Texas A&M University, College Station, TX 77843 (Dr Crouse).


JAMA. 1984;252(6):785-787. doi:10.1001/jama.1984.03350060029023
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References

The finding that high doses (160 mg) of zinc lowered high-density lipoprotein-cholesterol prompted us to study the effect of low-dose zinc supplementation on lipoprotein values in sedentary and endurance-trained men. Twenty-one endurance-trained and 23 sedentary men received either placebo or 50 mg of zinc sulfate daily for eight weeks. Despite the fact that plasma zinc increased 15%, fasting plasma high-density-lipoprotein cholesterol, total cholesterol, low-density-lipoprotein cholesterol, and triglyceride levels did not change in response to zinc ingestion. We conclude that low-dose zinc supplementation does not affect lipid or lipoprotein values in either endurance-trained or sedentary men.

(JAMA 1984;252:785-787)

REFERENCES

1 +
Klevay LM:  Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested . Am J Clin Nutr 1973;;26:1060-1068.
2 +
Klevay LM:  Coronary heart disease: The zinc/copper hypothesis . Am J Clin Nutr 1975;; 28:764-774.
3 +
Hooper PL, Visconti L, Garry PJ, et al:  Zinc lowers high-density lipoprotein-cholesterol levels . JAMA 1980;;244:1960-1961.
4 +
Hartung GH, Foreyt JP, Mitchell RE, et al:  Relation of diet to high-density lipoprotein-cholesterol in middle-aged marathon runners, joggers, and inactive men . N Engl J Med 1980;; 302:357-361.
5 +
Sutherland HF, Woodhouse SP:  Physical activity and plasma lipoprotein lipid concentrations in men . Atherosclerosis 1980;;37:285-292.
6 +
Williams PT, Wood PD, Haskell WL, et al:  The effects of running mileage and duration on plasma lipoprotein levels . JAMA 1982;;247:2674-2679.
7 +
Wood PD, Haskell WL, Stern MP, et al:  Plasma lipoprotein distributions in male and female runners . Ann NY Acad Sci 1977;;301:748-763.
8 +
Livin J, Zak B:  Automated determination of serum cholesterol . Clin Chem Acta 1964;;10:381-384.
9 +
Lopes-Virella MD, Stone P, Ellis S, et al:  Cholesterol determinations in high density lipoprotein separated by three different methods . Clin Chem 1977;;23:882-884.
10 +
Kessler G, Lederer H:  Fluorimetric measurement of triglycerides , in Skeggs LT (ed): Automation in Analytical Chemistry: Technicon Symposia . New York, Mediad, 1965;, pp 341-344.
11 +
Friedewalde WT, Levy RI, Fredrickson DS:  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge . Clin Chem 1972;;18:499-502.
12 +
Smith JC, Butrimovitz GP:  Direct measurement of zinc in plasma by atomic absorption spectroscopy . Clin Chem 1979;;25:1487-1491.
13 +
Harris RJ: A Primer of Multivariate Statistics . New York, Academic Press Inc, 1975;.
14 +
Freeland-Graves JH, Freidman BJ, Han WH, et al:  Effect of zinc supplementation on plasma high-density lipoprotein-cholesterol and zinc . Am J Clin Nutr 1982;;35:988-992.
15 +
Subcommittee on Zinc, Committee on Medical and Biologic Effects of Environmental Pollutants: Zinc . Baltimore, University Park Press, 1979;.
16 +
Adner MM, Castelli WP:  Elevated high-density lipoprotein levels in marathon runners . JAMA 1980;;243:534-536.
17 +
Vu Tran Z, Weltman A, Glass GV, et al:  The effects of exercise on blood lipids and lipoproteins: A metaanalysis of studies . Med Sci Sports Exerc 1983;;15:393-402.
18 +
Glass GV, McGaw B, Smith ML: Meta-Analysis in Social Research . Beverly Hills, Calif, Sage Publications, 1981;.

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1 +
Klevay LM:  Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested . Am J Clin Nutr 1973;;26:1060-1068.
2 +
Klevay LM:  Coronary heart disease: The zinc/copper hypothesis . Am J Clin Nutr 1975;; 28:764-774.
3 +
Hooper PL, Visconti L, Garry PJ, et al:  Zinc lowers high-density lipoprotein-cholesterol levels . JAMA 1980;;244:1960-1961.
4 +
Hartung GH, Foreyt JP, Mitchell RE, et al:  Relation of diet to high-density lipoprotein-cholesterol in middle-aged marathon runners, joggers, and inactive men . N Engl J Med 1980;; 302:357-361.
5 +
Sutherland HF, Woodhouse SP:  Physical activity and plasma lipoprotein lipid concentrations in men . Atherosclerosis 1980;;37:285-292.
6 +
Williams PT, Wood PD, Haskell WL, et al:  The effects of running mileage and duration on plasma lipoprotein levels . JAMA 1982;;247:2674-2679.
7 +
Wood PD, Haskell WL, Stern MP, et al:  Plasma lipoprotein distributions in male and female runners . Ann NY Acad Sci 1977;;301:748-763.
8 +
Livin J, Zak B:  Automated determination of serum cholesterol . Clin Chem Acta 1964;;10:381-384.
9 +
Lopes-Virella MD, Stone P, Ellis S, et al:  Cholesterol determinations in high density lipoprotein separated by three different methods . Clin Chem 1977;;23:882-884.
10 +
Kessler G, Lederer H:  Fluorimetric measurement of triglycerides , in Skeggs LT (ed): Automation in Analytical Chemistry: Technicon Symposia . New York, Mediad, 1965;, pp 341-344.
11 +
Friedewalde WT, Levy RI, Fredrickson DS:  Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge . Clin Chem 1972;;18:499-502.
12 +
Smith JC, Butrimovitz GP:  Direct measurement of zinc in plasma by atomic absorption spectroscopy . Clin Chem 1979;;25:1487-1491.
13 +
Harris RJ: A Primer of Multivariate Statistics . New York, Academic Press Inc, 1975;.
14 +
Freeland-Graves JH, Freidman BJ, Han WH, et al:  Effect of zinc supplementation on plasma high-density lipoprotein-cholesterol and zinc . Am J Clin Nutr 1982;;35:988-992.
15 +
Subcommittee on Zinc, Committee on Medical and Biologic Effects of Environmental Pollutants: Zinc . Baltimore, University Park Press, 1979;.
16 +
Adner MM, Castelli WP:  Elevated high-density lipoprotein levels in marathon runners . JAMA 1980;;243:534-536.
17 +
Vu Tran Z, Weltman A, Glass GV, et al:  The effects of exercise on blood lipids and lipoproteins: A metaanalysis of studies . Med Sci Sports Exerc 1983;;15:393-402.
18 +
Glass GV, McGaw B, Smith ML: Meta-Analysis in Social Research . Beverly Hills, Calif, Sage Publications, 1981;.

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