Transient, Marked, Unexplained Elevation of Serum Alkaline Phosphatase FREE

Peter G. Steinherz, MD; Laurel J. Steinherz, MD; Jerome S. Nisselbaum, PhD; M. Lois Murphy, MD

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JAMA. 1984;252(23):3289-3292. doi:10.1001/jama.1984.03350230049033

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ABSTRACT

ABSTRACT | REFERENCES

Five children, aged 16 to 38 months, were found to have serum alkaline phosphatase levels seven to 30 times the upper limit of the reference range. Studies suggested a skeletal origin for the enzyme. No other abnormalities or explanations for the unusual enzyme levels were found. The enzyme levels returned to the reference range. A retrospective review of the records of 74 children with lymphoblastic leukemia, who were 2 to 4 years of age at diagnosis, disclosed only four cases of transient, isolated serum alkaline phosphatase elevation similar in degree to those described herein. The review covered 661 patient-years of follow-up and 2,417 enzyme measurements. Benign, transient hyperphosphatasemia is a rarely recognized clinical entity. Awareness of this condition should curtail the extensive evaluation that may follow the detection of such an abnormality.

(JAMA 1984;252:3289-3292)

REFERENCES

ABSTRACT | REFERENCES

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