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October 19, 1984, Vol 252, No. 15 >
ARTICLE | October 19, 1984

Lipid Angiogenic Factor From Omentum FREE

Harry S. Goldsmith, MD; Ann L. Griffith, PhD; Allan Kupferman, PhD; Nicholas Catsimpoolas, PhD
[+] Author Affiliations

Reprint requests to Department of Surgery, Boston University School of Medicine, 75 E Newton St, Boston, MA 02118 (Dr Goldsmith).


JAMA. 1984;252(15):2034-2036. doi:10.1001/jama.1984.03350150034017
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References

Placing the omentum on the brain surface by surgical transposition or transplantation will result in the development of numerous neovascular connections between these two structures. This phenomenon occurs even in the absence of cerebral ischemia, which raised the question as to whether an angiogenic factor was causing the response. A lipid material obtained from the omentum contains a potent angiogenic factor extractable in a chloroform-methanol solvent mixture. Angiogenesis created by this material was observed in the rabbit cornea after only a single injection of the substance. The angiogenic material obtained from the omentum is abundant in supply. This important characteristic offers promise for the purification and identification of its structure, which should allow for extensive animal and clinical studies dealing with the development or inhibition of angiogenesis.

(JAMA 1984;252:2034-2036)

REFERENCES

1 +
Algire GH, Chalkey HW:  Vascular reactions of normal and malignant tissues in vivo: I. Vascular reactions of mice to wounds and to normal neoplastic transplants . JNCI 1945;;6:73-85.
2 +
Greenblatt M, Shubik P:  Tumor angiogenesis transfilter diffusion studies in the hamster by the transparent chamber technique . JNCI 1968;;41:111-113.
3 +
Gibrone MA Jr, Leapman SP, Cotran RS, et al:  Tumor dormancy in vivo by prevention of neovascularization . J Exp Med 1972;;136:261-276.
4 +
Folkman J, Langer R, Linhardt RJ, et al:  Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone . Science 1983;;221:719-725.
5 +
Lee A, Langer R:  Shark cartilage contains inhibitors of tumor angiogenesis . Science 1983;; 221:1185-1187.
6 +
Kumar S, Shahabuddin S, Haboubi N, et al:  Angiogenesis factor from human myocardial infarcts . Lancet 1983;;2:364-367.
7 +
Brown RA, Weiss JB, Tomlinson IW, et al:  Angiogenic factor from synovial fluid resembling that from tumors . Lancet 1980;;1:682-685.
8 +
Glaser BM, D'Amore RG, Brunson SK, et al:  The demonstration of angiogenic activity from ocular tissues: Preliminary report . Ophthalmology 1980;;87:440-446.
9 +
Federman H, Brown GC, Feldberg NT, et al:  Experimental ocular angiogenesis . Am J Ophthalmol 1980;;89:231-237.
10 +
Glaser BM, D'Amore PA, Michels RG:  The effect of human intraocular fluid on vascular endothelial cell migration . Ophthalmology 1981;; 88:986-991.
11 +
Greenburg GB, Hunt TK:  The proliferative response in vitro of vascular endothelial and smooth muscle cell exposed to wound fluids and macrophages . J Cell Physiol 1978;;97:353-360.
12 +
Knighton DR, Hunt TK, Scheuenstuhl H, et al:  Oxygen tension regulates the expression of angiogenesis factor by macrophages . Science 1983;;221:1283-1285.
13 +
Weiss JB, Brown RA, Kumar S, et al:  An angiogenic factor isolated from tumors: a potent low-molecular-weight compound . Br J Cancer 1979;;40:493-496.
14 +
Fencelau A, Watt S, Mello RJ:  Tumor angiogenic factor: Purification from the Walker 256 rat tumor . J Biol Chem 1981;;256:9605-9611.
15 +
McAslau BR, Hoffman H:  Endothelial stimulating factor from Walker carcinoma cells: Relation to tumor angiogenic factor . Exp Cell Res 1979;;119:181-190.
16 +
Hill CR, Kissun RD, Weiss JB, et al:  Angiogenic factor in vitreous form diabetic retinopathy . Experientia 1983;;39:583-585.
17 +
Banda MJ, Knighton DR, Hunt TK, et al:  Isolation of a nonmitogenic angiogenesis factor from wound fluid . Proc Natl Acad Sci USA 1982;;79:7773-7777.
18 +
D'Amore PA, Glaser BM, Brunson SK, et al:  Angiogenic activity from bovine retina: Partial purification and characterization . Proc Natl Acad Sci USA 1981;;78:3068-3072.
19 +
Kissun RD, Hill CR, Garner A, et al:  A low molecular weight angiogenic factor in cat retina . Br J Ophthalmol 1982;;66:165-169.
20 +
DeCarvalho S:  Angiokines, angiogenesis and angiolymphoproliferative syndromes (ALPS) . Angiology 1983;;34:231-243.
21 +
Frederick JL, Shimanuki T, DiZerega GS:  Initiation of angiogenesis by human follicular fluid . Science 1984;;224:389-390.
22 +
Burgos H:  Angiogenic and growth factors in human amnio-chorion and placenta . Eur J Clin Invest 1983;;13:289-296.
23 +
Castellot JJ Jr, Karnovsky MJ, Spiegelman BM:  Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes . Proc Nati Acad Sci USA 1982;;79:5597-5601.
24 +
Goldsmith HS, Chen WF, Duckett S:  Brain vascularization by intact omentum . Arch Surg 1973;;106:695-698.
25 +
Goldsmith HS, Duckett S, Chen WF:  Prevention of cerebral infarction in the dog by intact omentum . Am J Surg 1975;;130:317-320.
26 +
Goldsmith HS, Duckett S, Chen WF:  Spinal cord vascularization by intact omentum . Am J Surg 1975;;129:263-265.
27 +
Goldsmith HS, Duckett S, Chen WF:  Prevention of cerebral infarction in the monkey by omental transposition to the brain . Stroke 1978;; 9:224-229.
28 +
Goldsmith HS:  Omental transposition for peripheral vascular insufficiency . Rev Surg 1967;; 24:379-380.
29 +
Goldsmith HS:  Salvage of end-stage ischemic extremities by intact omentum . Surgery 1980;;88:732-736.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Algire GH, Chalkey HW:  Vascular reactions of normal and malignant tissues in vivo: I. Vascular reactions of mice to wounds and to normal neoplastic transplants . JNCI 1945;;6:73-85.
2 +
Greenblatt M, Shubik P:  Tumor angiogenesis transfilter diffusion studies in the hamster by the transparent chamber technique . JNCI 1968;;41:111-113.
3 +
Gibrone MA Jr, Leapman SP, Cotran RS, et al:  Tumor dormancy in vivo by prevention of neovascularization . J Exp Med 1972;;136:261-276.
4 +
Folkman J, Langer R, Linhardt RJ, et al:  Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone . Science 1983;;221:719-725.
5 +
Lee A, Langer R:  Shark cartilage contains inhibitors of tumor angiogenesis . Science 1983;; 221:1185-1187.
6 +
Kumar S, Shahabuddin S, Haboubi N, et al:  Angiogenesis factor from human myocardial infarcts . Lancet 1983;;2:364-367.
7 +
Brown RA, Weiss JB, Tomlinson IW, et al:  Angiogenic factor from synovial fluid resembling that from tumors . Lancet 1980;;1:682-685.
8 +
Glaser BM, D'Amore RG, Brunson SK, et al:  The demonstration of angiogenic activity from ocular tissues: Preliminary report . Ophthalmology 1980;;87:440-446.
9 +
Federman H, Brown GC, Feldberg NT, et al:  Experimental ocular angiogenesis . Am J Ophthalmol 1980;;89:231-237.
10 +
Glaser BM, D'Amore PA, Michels RG:  The effect of human intraocular fluid on vascular endothelial cell migration . Ophthalmology 1981;; 88:986-991.
11 +
Greenburg GB, Hunt TK:  The proliferative response in vitro of vascular endothelial and smooth muscle cell exposed to wound fluids and macrophages . J Cell Physiol 1978;;97:353-360.
12 +
Knighton DR, Hunt TK, Scheuenstuhl H, et al:  Oxygen tension regulates the expression of angiogenesis factor by macrophages . Science 1983;;221:1283-1285.
13 +
Weiss JB, Brown RA, Kumar S, et al:  An angiogenic factor isolated from tumors: a potent low-molecular-weight compound . Br J Cancer 1979;;40:493-496.
14 +
Fencelau A, Watt S, Mello RJ:  Tumor angiogenic factor: Purification from the Walker 256 rat tumor . J Biol Chem 1981;;256:9605-9611.
15 +
McAslau BR, Hoffman H:  Endothelial stimulating factor from Walker carcinoma cells: Relation to tumor angiogenic factor . Exp Cell Res 1979;;119:181-190.
16 +
Hill CR, Kissun RD, Weiss JB, et al:  Angiogenic factor in vitreous form diabetic retinopathy . Experientia 1983;;39:583-585.
17 +
Banda MJ, Knighton DR, Hunt TK, et al:  Isolation of a nonmitogenic angiogenesis factor from wound fluid . Proc Natl Acad Sci USA 1982;;79:7773-7777.
18 +
D'Amore PA, Glaser BM, Brunson SK, et al:  Angiogenic activity from bovine retina: Partial purification and characterization . Proc Natl Acad Sci USA 1981;;78:3068-3072.
19 +
Kissun RD, Hill CR, Garner A, et al:  A low molecular weight angiogenic factor in cat retina . Br J Ophthalmol 1982;;66:165-169.
20 +
DeCarvalho S:  Angiokines, angiogenesis and angiolymphoproliferative syndromes (ALPS) . Angiology 1983;;34:231-243.
21 +
Frederick JL, Shimanuki T, DiZerega GS:  Initiation of angiogenesis by human follicular fluid . Science 1984;;224:389-390.
22 +
Burgos H:  Angiogenic and growth factors in human amnio-chorion and placenta . Eur J Clin Invest 1983;;13:289-296.
23 +
Castellot JJ Jr, Karnovsky MJ, Spiegelman BM:  Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes . Proc Nati Acad Sci USA 1982;;79:5597-5601.
24 +
Goldsmith HS, Chen WF, Duckett S:  Brain vascularization by intact omentum . Arch Surg 1973;;106:695-698.
25 +
Goldsmith HS, Duckett S, Chen WF:  Prevention of cerebral infarction in the dog by intact omentum . Am J Surg 1975;;130:317-320.
26 +
Goldsmith HS, Duckett S, Chen WF:  Spinal cord vascularization by intact omentum . Am J Surg 1975;;129:263-265.
27 +
Goldsmith HS, Duckett S, Chen WF:  Prevention of cerebral infarction in the monkey by omental transposition to the brain . Stroke 1978;; 9:224-229.
28 +
Goldsmith HS:  Omental transposition for peripheral vascular insufficiency . Rev Surg 1967;; 24:379-380.
29 +
Goldsmith HS:  Salvage of end-stage ischemic extremities by intact omentum . Surgery 1980;;88:732-736.

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