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July 6, 1984, Vol 252, No. 1 >
ARTICLE | July 6, 1984

Analysis of Cytomegalovirus and Epstein-Barr Virus Antibody Responses in Treated Hemophiliacs: Title and subTitle BreakImplications for the Study of Acquired Immune Deficiency Syndrome FREE

Sarah H. Cheeseman, MD; John L. Sullivan, MD; Doreen B. Brettler, MD; Peter H. Levine, MD
[+] Author Affiliations

Reprint requests to Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01605 (Dr Cheeseman).


JAMA. 1984;252(1):83-85. doi:10.1001/jama.1984.03350010049023
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References

One hundred hemophiliacs were studied for serological evidence of infection with cytomegalovirus (CMV), Epstein-Barr virus (EBV), and hepatitis B virus. Ninety-eight percent had markers of hepatitis B infection, while 69% had antibody to EBV and only 42% had antibody to CMV, suggesting that factor VIII preparations do not transmit EBV and CMV efficiently. Seventy-one percent of those seropositive to EBV had an antibody pattern suggestive of active infection, as compared with 23% of healthy young adult blood donors. These findings make the patients with hemophilia an unusually favorable population for the study of the role of persistent viral infection in the immunodeficiency now found to be widespread in groups at high risk for acquired immune deficiency syndrome (AIDS) and for the contribution of CMV and EBV to AIDS itself.

(JAMA 1984;252:83-85)

REFERENCES

1 +
Lederman MM, Ratnoff OD, Scillian JJ, et al:  Impaired cell-mediated immunity in patients with classic hemophilia . N Engl J Med 1983;; 308:79-82.
2 +
Menitove JE, Aster RH, Casper JT, et al:  T-lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophilized concentrates . N Engl J Med 1983;;308:83-86.
3 +
Goldsmith JC, Moseley PL, Monick M, et al:  T-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia . Ann Intern Med 1983;;98:294-296.
4 +
Landay A, Poon M-C, Abo T, et al:  Immunologic studies in asymptomatic hemophilia patients: Relationship to acquired immune deficiency syndrome (AIDS) . J Clin Invest 1983;; 71:1500-1504.
5 +
Kornfeld H, Vande Stouwe RA, Lange M, et al:  T-lymphocyte subpopulation in homosexual men . N Engl J Med 1982;;307:729-731.
6 +
Stahl RE, Friedman-Kien A, Dubin R, et al:  Immunologic abnormalities in homosexual men: Relationship to Kaposi's sarcoma . Am J Med 1982;;74:171-178.
7 +
Wallace JI, Coral FS, Rimm IJ, et al:  T-cell ratios in homosexuals . Lancet 1982;;1:908.
8 +
Rogers MF, Morens DM, Stewart JA, et al:  Task Force on Acquired Immune Deficiency Syndrome: National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 2, laboratory results . Ann Intern Med 1983;;99:151-158.
9 +
Chang RS: Infectious Mononucleosis . Boston, GK Hall, 1980;, pp 123-126.
10 +
Davis LA, Stewart JA, Garvin S:  Cytomegalovirus infection: A seroepidemiologic comparison of nuns and women from a venereal disease clinic . Am J Epidemiol 1975;;102:327-330.
11 +
Deibel R, Smith R, Clarke LM, et al:  Cytomegalovirus infections in New York State: Laboratory studies of patients and healthy individuals . NY State J Med 1974;;74:785-791.
12 +
Kettering JD, Schmidt NJ, Lennette EH:  Improved glycine-extracted complement-fixing antigen for human cytomegalovirus . J Clin Microbiol 1977;;6:647-649.
13 +
Henle M, Henle G, Horowitz CA:  Infectious mononucleosis and Epstein-Barr virus associated malignancies , in Lennette EH, Schmidt NJ (eds): Diagnosis Procedures for Viral, Rickettsial and Chlamydial Infections , ed 5. Washington, DC, American Public Health Association, 1979;, pp 441-470.
14 +
Armstrong JA, Tarr GC, Youngblood LA, et al:  Cytomegalovirus infection in children undergoing open-heart surgery . Yale J Biol Med 1976;;49:83-91.
15 +
 Inactivated hepatitis B virus vaccine . MMWR 1982;;31:318.
16 +
Schooley RT, Hirsch MS, Colvin RB, et al:  Association of herpesvirus infections with T-lymphocyte-subset alterations, glomerulopathy, and opportunistic infections after renal transplantation . N Engl J Med 1983;;308:307-313.
17 +
Lange B, Arbeter A, Hewetson J, et al:  Longitudinal study of Epstein-Barr virus antibody titers and excretion in pediatric patients with Hodgkin's disease . Int J Cancer 1978;; 22:521-527.
18 +
Sullivan JL, Brewster FE, Cheeseman SH, et al:  Immunoregulatory defects in hemophilia . Federation Proc 1984;;43:1919.
19 +
Carney WP, Rubin RH, Hoffman RA, et al:  Analysis of T-lymphocyte subsets in cytomegalovirus mononucleosis . J Immunol 1981;;126:2114-2116.
20 +
Reinherz EL, O'Brien C, Rosenthal P, et al:  Cellular basis for viral-induced immunodeficiency: Analysis by monoclonal antibodies . J Immunol 1980;;125:1269-1274.

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1 +
Lederman MM, Ratnoff OD, Scillian JJ, et al:  Impaired cell-mediated immunity in patients with classic hemophilia . N Engl J Med 1983;; 308:79-82.
2 +
Menitove JE, Aster RH, Casper JT, et al:  T-lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophilized concentrates . N Engl J Med 1983;;308:83-86.
3 +
Goldsmith JC, Moseley PL, Monick M, et al:  T-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia . Ann Intern Med 1983;;98:294-296.
4 +
Landay A, Poon M-C, Abo T, et al:  Immunologic studies in asymptomatic hemophilia patients: Relationship to acquired immune deficiency syndrome (AIDS) . J Clin Invest 1983;; 71:1500-1504.
5 +
Kornfeld H, Vande Stouwe RA, Lange M, et al:  T-lymphocyte subpopulation in homosexual men . N Engl J Med 1982;;307:729-731.
6 +
Stahl RE, Friedman-Kien A, Dubin R, et al:  Immunologic abnormalities in homosexual men: Relationship to Kaposi's sarcoma . Am J Med 1982;;74:171-178.
7 +
Wallace JI, Coral FS, Rimm IJ, et al:  T-cell ratios in homosexuals . Lancet 1982;;1:908.
8 +
Rogers MF, Morens DM, Stewart JA, et al:  Task Force on Acquired Immune Deficiency Syndrome: National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Part 2, laboratory results . Ann Intern Med 1983;;99:151-158.
9 +
Chang RS: Infectious Mononucleosis . Boston, GK Hall, 1980;, pp 123-126.
10 +
Davis LA, Stewart JA, Garvin S:  Cytomegalovirus infection: A seroepidemiologic comparison of nuns and women from a venereal disease clinic . Am J Epidemiol 1975;;102:327-330.
11 +
Deibel R, Smith R, Clarke LM, et al:  Cytomegalovirus infections in New York State: Laboratory studies of patients and healthy individuals . NY State J Med 1974;;74:785-791.
12 +
Kettering JD, Schmidt NJ, Lennette EH:  Improved glycine-extracted complement-fixing antigen for human cytomegalovirus . J Clin Microbiol 1977;;6:647-649.
13 +
Henle M, Henle G, Horowitz CA:  Infectious mononucleosis and Epstein-Barr virus associated malignancies , in Lennette EH, Schmidt NJ (eds): Diagnosis Procedures for Viral, Rickettsial and Chlamydial Infections , ed 5. Washington, DC, American Public Health Association, 1979;, pp 441-470.
14 +
Armstrong JA, Tarr GC, Youngblood LA, et al:  Cytomegalovirus infection in children undergoing open-heart surgery . Yale J Biol Med 1976;;49:83-91.
15 +
 Inactivated hepatitis B virus vaccine . MMWR 1982;;31:318.
16 +
Schooley RT, Hirsch MS, Colvin RB, et al:  Association of herpesvirus infections with T-lymphocyte-subset alterations, glomerulopathy, and opportunistic infections after renal transplantation . N Engl J Med 1983;;308:307-313.
17 +
Lange B, Arbeter A, Hewetson J, et al:  Longitudinal study of Epstein-Barr virus antibody titers and excretion in pediatric patients with Hodgkin's disease . Int J Cancer 1978;; 22:521-527.
18 +
Sullivan JL, Brewster FE, Cheeseman SH, et al:  Immunoregulatory defects in hemophilia . Federation Proc 1984;;43:1919.
19 +
Carney WP, Rubin RH, Hoffman RA, et al:  Analysis of T-lymphocyte subsets in cytomegalovirus mononucleosis . J Immunol 1981;;126:2114-2116.
20 +
Reinherz EL, O'Brien C, Rosenthal P, et al:  Cellular basis for viral-induced immunodeficiency: Analysis by monoclonal antibodies . J Immunol 1980;;125:1269-1274.

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