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July 6, 1984, Vol 252, No. 1 >
ARTICLE | July 6, 1984

Herpesvirus Infections in the Acquired Immune Deficiency Syndrome FREE

Gerald V. Quinnan, Jr, MD; Henry Masur, MD; Alain H. Rook, MD; Gary Armstrong; Winston R. Frederick, MD; Jay Epstein, MD; Jody F. Manischewitz, MS; Abe M. Macher, MD; Lozannie Jackson; John Ames; Holly A. Smith; Margaret Parker, MD; Gary R. Pearson, PhD; Joseph Parrillo, MD; Charles Mitchell, MD; Stephen E. Straus, MD
[+] Author Affiliations

Reprint requests to Bldg 29A, HFN-840, 8800 Rockville Pike, Bethesda, MD 20205 (Dr Quinnan).


JAMA. 1984;252(1):72-77. doi:10.1001/jama.1984.03350010038020
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References

Herpesvirus infections were studied in persons with or at risk for the acquired immune deficiency syndrome (AIDS). The infections diagnosed were as follows: patients with AIDS, cytomegalovirus (CMV) in 34 of 34, Epstein-Barr virus (EBV) in 33 of 34, herpes simplex viruses (HSV) in eight of 34, and varicella zoster virus in four of 34; patients with chronic lymphadenopathy syndrome, CMV in eight of nine and EBV in nine of nine; in healthy homosexual men, CMV in five of 13 and EBV in seven of eight. Cytomegalovirus infections were frequently related to disease and death. Herpesvirus infections are frequent causes of serious diseases in AIDS. The prevalence of EBV and CMV infections in AIDS and the chronic lymphadenopathy syndrome may be the result of an important interaction between these viruses and the cause of AIDS.

(JAMA 1984;252:72-77)

REFERENCES

1 +
Seigal FP, Lopez C, Hammer GS, et al:  Severe acquired immunodeficiency in male homosexuals manifested by chronic herpes simplex lesions . N Engl J Med 1981;;305:1439-1444.
2 +
 Persistent generalized lymphadenopathy among homosexual males . MMWR 1982;;31:249-251.
3 +
Drew WL, Miner RC, Ziegler JL, et al:  Cytomegalovirus and Kaposi's sarcoma in young homosexual men . Lancet 1982;;2:125-127.
4 +
Rogers MF, Morenis DM, Stewart JA, et al:  National case control of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Laboratory results . Ann Intern Med , in press.
5 +
Sonnabend J, Witkin SS, Purtilo DT:  Acquired immunodeficiency syndrome, opportunistic infections, and malignancies in male homosexuals: A hypothesis of etiologic factors in pathogenesis . JAMA 1983;;249:2370-2374.
6 +
Fenoglio CM, Oster MW, LaGerfo P:  Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: Demonstration of cytomegalovirus RNA in sarcoma cells . Hum Pathol 1982;;13:955-959.
7 +
Magrath JT, Erickson J, Whong-Peng J, et al:  Synthesis of kappa light chains by a cell line containing an 8:22 translation derived from a male homosexual with Burkitt's lymphoma . Science 1983;;222:1094-1098.
8 +
Hochberg FH, Miller G, Schooley RT, et al:  Central nervous system lymphoma related to Epstein-Barr virus . N Engl J Med 1983;;309:745-748.
9 +
Quinnan GV, Ennis FA:  Cell-mediated immunity in cytomegalovirus infections—a review . Comp Immunol Microbiol Infect Dis 1980;; 3:283-290.
10 +
DeWaele M, Thielemans C, Van Comp BKG:  Characterization of immunoregulatory T cells in EBV-induced infectious mononucleosis by monoclonal antibodies . N Engl J Med 1981;; 304:460-462.
11 +
Acquired immune deficiency syndrome (AIDS):  Update—United States MMWR 1982;; 31:507-508, 513-514.
12 +
Quinnan GV, Rook AH, Frederick WR, et al:  Prevalence, clinical manifestations, and immunology of herpesvirus infections in the acquired immunodeficiency syndrome . Proc NY Acad Sci , in press.
13 +
Tokumaru T:  Herpesviruses, herpesvirus hominis, herpesvirus simiae, herpesvirus suis , in Lennette EH, Schmidt NJ (eds): Diagnostic Procedures for Viral and Rickettsial Infections . New York, American Public Health Association Inc, 1969;, pp 641-700.
14 +
Benyesh-Melnick M:  Cytomegaloviruses , in Lennette EH, Schmidt NJ (eds): Diagnostic Procedures for Viral and Rickettsial Infections . New York, American Public Health Association Inc, 1969;, pp 701-732.
15 +
Miller G, Robinson J, Heston L, et al:  Difference between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference . Proc Natl Acad Sci USA 1974;;71:4006-4010.
16 +
Rickinson AB, Moss DJ, Pope JH:  Long-term cell-mediated immunity to Epstein-Barr virus in man: II. Components necessary for regression in virus-infected leukocyte cultures . J Cancer 1979;;23:610-617.
17 +
Kettering JD, Schmidt NJ, Gallo D, et al:  Anticomplement immunofluorescence test for antibodies to human cytomegalovirus . J Clin Microbiol 1977;;6:627-632.
18 +
Castellano GA, Hazzard GT, Madden DL, et al:  Comparison of the enzyme-linked immunosorbent assay and the indirect hemagglutination test for detection of antibody to cytomegalovirus . J Infect Dis 1977;;136( (suppl) ):3337-3339.
19 +
Bruck C, Portetelle D, Glineur G, et al:  One-step purification of mouse monoclonal antibodies from ascitis fluid by DEAE affi-Gel blue chromatography . J Immunol Meth 1982;;53:313-319.
20 +
Henle G, Henle W:  Immunofluorescence in cells derived from Burkitt's lymphoma . J Bacteriol 1966;;91:1248-1256.
21 +
Henle G, Henle W, Klein S:  Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus infected cells . Int J Cancer 1971;;8:272-282.
22 +
Reedman BM, Klein G:  Cellular localization of an EBV-associated complement fixing antigen in producer and non-producer lymphoblastoid cell lines . Int J Cancer 1973;;11:499-520.
23 +
Armstrong GR, Longo A, Faggioni H, et al:  Detection and isolation of Epstein-Barr virus in lymphocytes from patients with chronic B lymphocytic leukemia (CLL) , in Magrath IT, O'Connor GT, Ramon B (eds): Environmental Influence on the Pathogenesis of Leukemias and Lymphomas . New York, Raven Press, in press.
24 +
Qualtiere LF, Chase R, Vroman B, et al:  Identification of Epstein-Barr virus differences with monoclonal antibody to membrane glycoprotein . Proc Natl Acad Sci USA 1982;;79:616-620.
25 +
Kirmani N, Quinnan GV, Albrecht P, et al:  Comparison of enzyme-linked immunoassay, complement fixation, neutralizing antibody and enhanced neutralization test for evaluation of risk from cytomegalovirus infection in bone marrow transplant recipients . Curr Chemother Infect Dis 1979;;2:1318-1319.
26 +
Niederman JC, Evans AS, Subrahmanyan L, et al:  Prevalence, incidence, and persistence of EB virus antibody in young adults . N Engl J Med 1970;;282:361-365.
27 +
Macher A, Reichert C, Straus S, et al:  Death in the AIDS patient: Role of cytomegalovirus . N Engl J Med 1983;;309:1454.
28 +
Elfenbein GJ, Saral R:  Infectious disease during immune recovery after bone marrow transplantation , in Allen JC (ed): Infection in the Compromised Host . Baltimore, Williams & Wilkins Co, 1981;, pp 157-196.
29 +
Ho M:  Virus infections after transplantation in man . Arch Virol 1977;;55:1-24.
30 +
Klemola E, von Essen R, Wager O, et al:  Cytomegalovirus mononucleosis in previously healthy individuals . Ann Intern Med 1969;;71:11-19.
31 +
Niederman JC, McCollum RW, Henle G, et al:  Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies . JAMA 1968;;203:205-209.
32 +
Glade PR, Chessin LN:  Infectious mononucleosis: Immunoglobulin synthesis by cell lines . J Clin Invest 1968;;47:2391-2401.
33 +
Lane HC, Masur H, Edgar LC, et al:  Abnormalities of B cell activation and immuno-regulation in patients with the acquired immune deficiency syndrome . N Engl J Med 1983;;309:453-458.
34 +
Carney WP, Rubin RH, Hoffman RA, et al:  Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis . J Immunol 1981;;126:2114-2116.
35 +
Rand KH, Pollard RB, Merigan TC:  Increased pulmonary superinfections in cardiac transplant patients undergoing primary cytomegalovirus infections . N Engl J Med 1978;; 298:951-953.
36 +
Rytel MW, Aguilar-Torres FG, Balay J, et al:  Assessment of the status of cell-mediated immunity in cytomegalovirus-infected renal allograft recipients . Cell Immunol 1978;;37:31-40.
37 +
Plummer G:  Cytomegaloviruses of man and animals . Prog Med Virol 1973;;15:92-125.
38 +
 CDC Task Force on Kaposi's Sarcoma and Opportunistic Infections: Epidemiological aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections . N Engl J Med 1982;;306:248-252.
39 +
Rook AH, Quinnan GV:  Cytomegalovirus infections following blood transfusion , in Tabor E (ed): Infectious Complications of Blood Transfusions . New York, Academic Press Inc, 1982;, pp 45-63.
40 +
Rickinson AM, Jarvis JE, Crawford DH, et al:  Observations on the type of infection by Epstein-Barr virus in peripheral lymphoid cells of patients with infectious mononucleosis . Int J Cancer 1974;;14:704-716.
41 +
Klein G, Svedmyz E, Jondal M, et al:  EBV determined nuclear antigen (EBNA) positive cells in the peripheral blood of infectious mononucleosis patients . Int J Cancer 1976;;17:21-26.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Seigal FP, Lopez C, Hammer GS, et al:  Severe acquired immunodeficiency in male homosexuals manifested by chronic herpes simplex lesions . N Engl J Med 1981;;305:1439-1444.
2 +
 Persistent generalized lymphadenopathy among homosexual males . MMWR 1982;;31:249-251.
3 +
Drew WL, Miner RC, Ziegler JL, et al:  Cytomegalovirus and Kaposi's sarcoma in young homosexual men . Lancet 1982;;2:125-127.
4 +
Rogers MF, Morenis DM, Stewart JA, et al:  National case control of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: Laboratory results . Ann Intern Med , in press.
5 +
Sonnabend J, Witkin SS, Purtilo DT:  Acquired immunodeficiency syndrome, opportunistic infections, and malignancies in male homosexuals: A hypothesis of etiologic factors in pathogenesis . JAMA 1983;;249:2370-2374.
6 +
Fenoglio CM, Oster MW, LaGerfo P:  Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: Demonstration of cytomegalovirus RNA in sarcoma cells . Hum Pathol 1982;;13:955-959.
7 +
Magrath JT, Erickson J, Whong-Peng J, et al:  Synthesis of kappa light chains by a cell line containing an 8:22 translation derived from a male homosexual with Burkitt's lymphoma . Science 1983;;222:1094-1098.
8 +
Hochberg FH, Miller G, Schooley RT, et al:  Central nervous system lymphoma related to Epstein-Barr virus . N Engl J Med 1983;;309:745-748.
9 +
Quinnan GV, Ennis FA:  Cell-mediated immunity in cytomegalovirus infections—a review . Comp Immunol Microbiol Infect Dis 1980;; 3:283-290.
10 +
DeWaele M, Thielemans C, Van Comp BKG:  Characterization of immunoregulatory T cells in EBV-induced infectious mononucleosis by monoclonal antibodies . N Engl J Med 1981;; 304:460-462.
11 +
Acquired immune deficiency syndrome (AIDS):  Update—United States MMWR 1982;; 31:507-508, 513-514.
12 +
Quinnan GV, Rook AH, Frederick WR, et al:  Prevalence, clinical manifestations, and immunology of herpesvirus infections in the acquired immunodeficiency syndrome . Proc NY Acad Sci , in press.
13 +
Tokumaru T:  Herpesviruses, herpesvirus hominis, herpesvirus simiae, herpesvirus suis , in Lennette EH, Schmidt NJ (eds): Diagnostic Procedures for Viral and Rickettsial Infections . New York, American Public Health Association Inc, 1969;, pp 641-700.
14 +
Benyesh-Melnick M:  Cytomegaloviruses , in Lennette EH, Schmidt NJ (eds): Diagnostic Procedures for Viral and Rickettsial Infections . New York, American Public Health Association Inc, 1969;, pp 701-732.
15 +
Miller G, Robinson J, Heston L, et al:  Difference between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference . Proc Natl Acad Sci USA 1974;;71:4006-4010.
16 +
Rickinson AB, Moss DJ, Pope JH:  Long-term cell-mediated immunity to Epstein-Barr virus in man: II. Components necessary for regression in virus-infected leukocyte cultures . J Cancer 1979;;23:610-617.
17 +
Kettering JD, Schmidt NJ, Gallo D, et al:  Anticomplement immunofluorescence test for antibodies to human cytomegalovirus . J Clin Microbiol 1977;;6:627-632.
18 +
Castellano GA, Hazzard GT, Madden DL, et al:  Comparison of the enzyme-linked immunosorbent assay and the indirect hemagglutination test for detection of antibody to cytomegalovirus . J Infect Dis 1977;;136( (suppl) ):3337-3339.
19 +
Bruck C, Portetelle D, Glineur G, et al:  One-step purification of mouse monoclonal antibodies from ascitis fluid by DEAE affi-Gel blue chromatography . J Immunol Meth 1982;;53:313-319.
20 +
Henle G, Henle W:  Immunofluorescence in cells derived from Burkitt's lymphoma . J Bacteriol 1966;;91:1248-1256.
21 +
Henle G, Henle W, Klein S:  Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus infected cells . Int J Cancer 1971;;8:272-282.
22 +
Reedman BM, Klein G:  Cellular localization of an EBV-associated complement fixing antigen in producer and non-producer lymphoblastoid cell lines . Int J Cancer 1973;;11:499-520.
23 +
Armstrong GR, Longo A, Faggioni H, et al:  Detection and isolation of Epstein-Barr virus in lymphocytes from patients with chronic B lymphocytic leukemia (CLL) , in Magrath IT, O'Connor GT, Ramon B (eds): Environmental Influence on the Pathogenesis of Leukemias and Lymphomas . New York, Raven Press, in press.
24 +
Qualtiere LF, Chase R, Vroman B, et al:  Identification of Epstein-Barr virus differences with monoclonal antibody to membrane glycoprotein . Proc Natl Acad Sci USA 1982;;79:616-620.
25 +
Kirmani N, Quinnan GV, Albrecht P, et al:  Comparison of enzyme-linked immunoassay, complement fixation, neutralizing antibody and enhanced neutralization test for evaluation of risk from cytomegalovirus infection in bone marrow transplant recipients . Curr Chemother Infect Dis 1979;;2:1318-1319.
26 +
Niederman JC, Evans AS, Subrahmanyan L, et al:  Prevalence, incidence, and persistence of EB virus antibody in young adults . N Engl J Med 1970;;282:361-365.
27 +
Macher A, Reichert C, Straus S, et al:  Death in the AIDS patient: Role of cytomegalovirus . N Engl J Med 1983;;309:1454.
28 +
Elfenbein GJ, Saral R:  Infectious disease during immune recovery after bone marrow transplantation , in Allen JC (ed): Infection in the Compromised Host . Baltimore, Williams & Wilkins Co, 1981;, pp 157-196.
29 +
Ho M:  Virus infections after transplantation in man . Arch Virol 1977;;55:1-24.
30 +
Klemola E, von Essen R, Wager O, et al:  Cytomegalovirus mononucleosis in previously healthy individuals . Ann Intern Med 1969;;71:11-19.
31 +
Niederman JC, McCollum RW, Henle G, et al:  Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies . JAMA 1968;;203:205-209.
32 +
Glade PR, Chessin LN:  Infectious mononucleosis: Immunoglobulin synthesis by cell lines . J Clin Invest 1968;;47:2391-2401.
33 +
Lane HC, Masur H, Edgar LC, et al:  Abnormalities of B cell activation and immuno-regulation in patients with the acquired immune deficiency syndrome . N Engl J Med 1983;;309:453-458.
34 +
Carney WP, Rubin RH, Hoffman RA, et al:  Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis . J Immunol 1981;;126:2114-2116.
35 +
Rand KH, Pollard RB, Merigan TC:  Increased pulmonary superinfections in cardiac transplant patients undergoing primary cytomegalovirus infections . N Engl J Med 1978;; 298:951-953.
36 +
Rytel MW, Aguilar-Torres FG, Balay J, et al:  Assessment of the status of cell-mediated immunity in cytomegalovirus-infected renal allograft recipients . Cell Immunol 1978;;37:31-40.
37 +
Plummer G:  Cytomegaloviruses of man and animals . Prog Med Virol 1973;;15:92-125.
38 +
 CDC Task Force on Kaposi's Sarcoma and Opportunistic Infections: Epidemiological aspects of the current outbreak of Kaposi's sarcoma and opportunistic infections . N Engl J Med 1982;;306:248-252.
39 +
Rook AH, Quinnan GV:  Cytomegalovirus infections following blood transfusion , in Tabor E (ed): Infectious Complications of Blood Transfusions . New York, Academic Press Inc, 1982;, pp 45-63.
40 +
Rickinson AM, Jarvis JE, Crawford DH, et al:  Observations on the type of infection by Epstein-Barr virus in peripheral lymphoid cells of patients with infectious mononucleosis . Int J Cancer 1974;;14:704-716.
41 +
Klein G, Svedmyz E, Jondal M, et al:  EBV determined nuclear antigen (EBNA) positive cells in the peripheral blood of infectious mononucleosis patients . Int J Cancer 1976;;17:21-26.

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