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February 10, 1984, Vol 251, No. 6 >
ARTICLE | February 10, 1984

Reye's Syndrome Associated With Long-term Aspirin Therapy FREE

Richard S. K. Young, MD; Dennis Torretti, MD; Robert H. Williams, MD; Donald Hendriksen, MD; Michael Woods, MD
[+] Author Affiliations

Reprint requests to Division of Pediatric Neurology, The Milton S. Hershey Medical Center, The Pennsylvania State University, PO Box 850, Hershey, PA 17033 (Dr Young).


JAMA. 1984;251(6):754-756. doi:10.1001/jama.1984.03340300046027
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References

Reye's syndrome has been infrequently described in children receiving long-term salicylate therapy. We report the clinical and laboratory findings of two children in whom Reye's syndrome developed while taking salicylates for systemic inflammatory disorders. Monitoring of hepatocellular function should be considered in children who are receiving long-term salicylate therapy.

(JAMA 1984;251:754-756)

REFERENCES

1 +
Brown AK, Fikrig S, Finberg L:  Aspirin and Reye syndrome . J Pediatr 1983;;102:157-158.
2 +
Waldman RJ, Hall WN, McGee H, et al:  Aspirin as a risk factor in Reye's syndrome . JAMA 1982;;247:3089-3094.
3 +
Starko KM, Mullick FG:  Hepatic and cerebral pathology findings in children with fatal salicylate intoxication: Further evidence for a causal relation between salicylate and Reye's syndrome . Lancet 1983;;1:326-329.
4 +
Christoffersen P, Faarup P, Geertinger P, et al:  Reye's syndrome in a child on long-term salicylate medication . Forensic Sci Int 1980;; 15:129-133.
5 +
Sillanpaa M, Makela AL, Koivikko A:  Acute liver failure and encephalography (Reye's syndrome) during salicylate therapy . Acta Paediatr Scand 1975;;64:877-880.
6 +
Linnemann CC, Shea L, Partin JC, et al:  Reye's syndrome: Epidemiologic and viral studies . Am J Epidemiol 1975;;101:517-526.
7 +
Riviello JJ, Grover WD, Goldsmith DP, et al:  Evidence that rheumatic encephalopathy may represent Reye syndrome . Pediatr Res 1983;; 17:367.
8 +
Ulshen MH, Grand RJ, Crain JD, et al:  Hepatotoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis . J Pediatr 1978;;93:1034-1037
9 +
Athreya BH, Moser G, Cecil HS, et al:  Aspirin-induced hepatotoxicity in juvenile rheumatoid arthritis . Arthritis Rheum 1975;;18:347-352.
10 +
Levinson JE, Baum J, Brewer E, et al:  Comparison of tolmetin sodium and aspirin in the treatment of juvenile rheumatoid arthritis . J Pediatr 1977;;91:799-804.
11 +
Rich RR, Johnson JS:  Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis . Arthritis Rheum 1973;;16:1-9.
12 +
Petty BG, Zahka, KG, Bernstein MT:  Aspirin hepatitis associated with encephalopathy . J Pediatr 1978;;93:881-882.
13 +
Lichtenstein PK, Heubi JE, Daugherty CC, et al:  Grade I Reye's syndrome: A frequent cause of vomiting and liver dysfunction after varicella and upper respiratory tract infection . N Engl J Med 1983;;309:133-139.
14 +
You KS:  Salicylate and mitochondrial injury in Reye's syndrome . Science 1983;;221:163-164.
15 +
Committee of Infectious Diseases, American Academy of Pediatrics:  Aspirin and Reye syndrome . Pediatrics 1982;;69:810-812.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Brown AK, Fikrig S, Finberg L:  Aspirin and Reye syndrome . J Pediatr 1983;;102:157-158.
2 +
Waldman RJ, Hall WN, McGee H, et al:  Aspirin as a risk factor in Reye's syndrome . JAMA 1982;;247:3089-3094.
3 +
Starko KM, Mullick FG:  Hepatic and cerebral pathology findings in children with fatal salicylate intoxication: Further evidence for a causal relation between salicylate and Reye's syndrome . Lancet 1983;;1:326-329.
4 +
Christoffersen P, Faarup P, Geertinger P, et al:  Reye's syndrome in a child on long-term salicylate medication . Forensic Sci Int 1980;; 15:129-133.
5 +
Sillanpaa M, Makela AL, Koivikko A:  Acute liver failure and encephalography (Reye's syndrome) during salicylate therapy . Acta Paediatr Scand 1975;;64:877-880.
6 +
Linnemann CC, Shea L, Partin JC, et al:  Reye's syndrome: Epidemiologic and viral studies . Am J Epidemiol 1975;;101:517-526.
7 +
Riviello JJ, Grover WD, Goldsmith DP, et al:  Evidence that rheumatic encephalopathy may represent Reye syndrome . Pediatr Res 1983;; 17:367.
8 +
Ulshen MH, Grand RJ, Crain JD, et al:  Hepatotoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis . J Pediatr 1978;;93:1034-1037
9 +
Athreya BH, Moser G, Cecil HS, et al:  Aspirin-induced hepatotoxicity in juvenile rheumatoid arthritis . Arthritis Rheum 1975;;18:347-352.
10 +
Levinson JE, Baum J, Brewer E, et al:  Comparison of tolmetin sodium and aspirin in the treatment of juvenile rheumatoid arthritis . J Pediatr 1977;;91:799-804.
11 +
Rich RR, Johnson JS:  Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis . Arthritis Rheum 1973;;16:1-9.
12 +
Petty BG, Zahka, KG, Bernstein MT:  Aspirin hepatitis associated with encephalopathy . J Pediatr 1978;;93:881-882.
13 +
Lichtenstein PK, Heubi JE, Daugherty CC, et al:  Grade I Reye's syndrome: A frequent cause of vomiting and liver dysfunction after varicella and upper respiratory tract infection . N Engl J Med 1983;;309:133-139.
14 +
You KS:  Salicylate and mitochondrial injury in Reye's syndrome . Science 1983;;221:163-164.
15 +
Committee of Infectious Diseases, American Academy of Pediatrics:  Aspirin and Reye syndrome . Pediatrics 1982;;69:810-812.

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