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ARTICLE |

Embryo Transfer and Ectopic Pregnancy FREE

Leslie Iffy, MD
JAMA. 1984;251(20):2660-2660. doi:10.1001/jama.1984.03340440020015
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To the Editor.—  The important article of Dr Gary D. Hodgen1 describing surrogate embryo transfer in monkeys mentions the unexpected demise of one of the donors from tuboovarian ectopic pregnancy. Much to his credit, the author did not dismiss this observation, obviously unrelated to the field of his primary interest, but discussed it in some detail and aptly concluded that most likely "it was a result of the procedure" that involved retrograde lavage of the reproductive tract during the process of collecting ova. He attributed, therefore, the ectopic displacement and implantation of the ovum to "retrograde flow."In the light of this interesting observation, it deserves mention that the first successful attempt by Steptoe and Edwards2 of reimplanting an ovum fertilized in vitro resulted in tubal implantation under circumstances similar to those described by Dr Hodgen. The mechanism itself that he held responsible for the accidental ectopic implantation

REFERENCES

Hodgen GD:  Surrogate embryo transfer combined with estrogen-progesterone therapy in monkeys: Implantation, gestation, and delivery without ovaries . JAMA 1983;;250:2167-2171.
Steptoe PC, Edwards RG:  Reimplantation of human embryo with subsequent tubal pregnancy . Lancet 1976;; 1:880.
Iffy L:  Contribution to the aetiology of ectopic pregnancy . J Obstet Gynaecol Br Commonw 1961;;68:441.
Iffy L:  Contribution to the etiology of placenta previa . Am J Obstet Gynecol 1962;;83:869.
Iffy L:  Ectopic pregnancy , in Iffy L, Kaminetzky HA (eds): Principles and Practice of Obstetrics and Perinatology . New York, John Wiley & Sons Inc, 1981;, p 609.
Ruch TC: Diseases in Laboratory Primates . Philadelphia, WB Saunders Co, 1958;.

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Hodgen GD:  Surrogate embryo transfer combined with estrogen-progesterone therapy in monkeys: Implantation, gestation, and delivery without ovaries . JAMA 1983;;250:2167-2171.
Steptoe PC, Edwards RG:  Reimplantation of human embryo with subsequent tubal pregnancy . Lancet 1976;; 1:880.
Iffy L:  Contribution to the aetiology of ectopic pregnancy . J Obstet Gynaecol Br Commonw 1961;;68:441.
Iffy L:  Contribution to the etiology of placenta previa . Am J Obstet Gynecol 1962;;83:869.
Iffy L:  Ectopic pregnancy , in Iffy L, Kaminetzky HA (eds): Principles and Practice of Obstetrics and Perinatology . New York, John Wiley & Sons Inc, 1981;, p 609.
Ruch TC: Diseases in Laboratory Primates . Philadelphia, WB Saunders Co, 1958;.
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