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ARTICLE |

Hypertension and Its Treatment FREE

Oglesby Paul, MD
[+] Author Affiliations

Address editorial communications to the Editor, 535 N Dearborn St, Chicago, IL 60610.


JAMA. 1983;250(7):939-940. doi:10.1001/jama.1983.03340070045027
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The topic of hypertension is one that has received an enormous amount of attention during the past 50 years. The pathology has been extensively described and investigated, and the role of the kidney, including the thousands of studies on the renin-angiotensin system, has been of continuing intense interest. The contributions of neurohumoral influences on hypertension have also been vigorously studied, and the clinical and epidemiologic features have been subject to intense scrutiny—to mention only some of the areas of concern. Great expectations for an early cure of hypertension when the Goldblatt kidney preparation (1934) and renin (1939) were first described were not realized with the passage of time. The mosaic theory of Page1 emphasized the complexity of the problem and the existence and the interrelations of multiple forces leading to a common event—raised arterial BP. Forms of treatment existing in the 1930s and 1940s were not satisfactory, including the

REFERENCES

Page IH:  The mosaic theory 32 years later . Hypertension 1982;;4:177.
Schroeder HA:  Control of hypertension by hexamethonium and 1-hydrazinophthalazine: Preliminary observations . Arch Intern Med 1952;;89:523-540.
Wilkins RW:  New drugs for hypertension with special reference to chlorothiazide . N Engl J Med 1957;;257:1026-1030.
 Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg . JAMA 1967;;202:1028-1034.
Wilber JA, Barrow JG:  Hypertension—a community problem . Am J Med 1972;;52:653-663.
Multiple Risk Factor Intervention Trial Research Group:  Multiple Risk Factor Intervention Trial: Risk factor changes and mortality results . JAMA 1982;;248:1465-1477.
Moriyama IM, Krueger DE, Stamler J: Cardiovascular Diseases in the United States . Cambridge, Mass, Harvard University Press, 1971;, pp 158-159, 218-219.
Berenson GS, Frank GC, Hunter SM, et al:  Cardiovascular risk factors in children: Should they concern the pediatrician? Am J Dis Child 1982;;136:855-862.
Watt GCM, Edwards C, Hart JT, et al:  Dietary sodium restriction for mild hypertension in general practice . Br Med J 1983;;286:432-436.
MacGregor GA, Markandu ND, Best FE, et al:  Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension . Lancet 1982;;1:351-354.

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Page IH:  The mosaic theory 32 years later . Hypertension 1982;;4:177.
Schroeder HA:  Control of hypertension by hexamethonium and 1-hydrazinophthalazine: Preliminary observations . Arch Intern Med 1952;;89:523-540.
Wilkins RW:  New drugs for hypertension with special reference to chlorothiazide . N Engl J Med 1957;;257:1026-1030.
 Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg . JAMA 1967;;202:1028-1034.
Wilber JA, Barrow JG:  Hypertension—a community problem . Am J Med 1972;;52:653-663.
Multiple Risk Factor Intervention Trial Research Group:  Multiple Risk Factor Intervention Trial: Risk factor changes and mortality results . JAMA 1982;;248:1465-1477.
Moriyama IM, Krueger DE, Stamler J: Cardiovascular Diseases in the United States . Cambridge, Mass, Harvard University Press, 1971;, pp 158-159, 218-219.
Berenson GS, Frank GC, Hunter SM, et al:  Cardiovascular risk factors in children: Should they concern the pediatrician? Am J Dis Child 1982;;136:855-862.
Watt GCM, Edwards C, Hart JT, et al:  Dietary sodium restriction for mild hypertension in general practice . Br Med J 1983;;286:432-436.
MacGregor GA, Markandu ND, Best FE, et al:  Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension . Lancet 1982;;1:351-354.
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