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The Dilemma of 'Mild' Hypertension: Title and subTitle BreakAnother Viewpoint of Treatment FREE

Ray W. Gifford, Jr, MD; Nemat Borhani, MD; Iqbal Krishan, MD; Marvin Moser, MD; Robert I. Levy, MD; James A. Schoenberger, MD
[+] Author Affiliations

Reprint requests to Department of Hypertension and Nephrology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44106 (Dr Gifford).


JAMA. 1983;250(23):3171-3173. doi:10.1001/jama.1983.03340230023021
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THE ISSUE of whether to treat "mild" hypertension is more controversial than the two articles1,2 and one editorial3 that were published in the Jan 21 issue of JAMA would lead the unsuspecting reader to believe. There are many who believe that the evidence favors the use of drug therapy to reduce diastolic BP when it is consistently above 90 mm Hg despite a three- to six-month trial of appropriate nonpharmacologic (eg, dietary) treatment.

This issue is not an inconsequential academic controversy. The lives and well-being of more than 20 million Americans with mild hypertension are at risk. The Hypertension Detection and Follow-up Program (HDFP) data indicate that rigorous treatment of mild hypertension decreases the five-year mortality by 20.3% (from 7.4% in the referred care [RC] group to 5.9% in the stepped care [SC] group [P<.01]).4 Even to concede Dr Pickering's "of or by" dilemma, a simple

REFERENCES

Kaplan NM:  Therapy for mild hypertension . JAMA 1983;;249:365-367.
McAlister NH:  Should we treat mild hypertension? JAMA 1983;; 365:379-382.
Pickering TG:  Treatment of mild hypertension and the reduction of cardiovascular mortality: The 'of or by' dilemma . JAMA 1983;;249:399-400.
 Hypertension Detection and Follow-up Program Cooperative Group: The effect of treatment on mortality in 'mild' hypertension: Results of the Hypertension Detection and Follow-up Program . N Engl J Med 1982;; 307:976-980.
Hardy RJ, Hawkins CM:  The impact of selected indices of antihypertensive treatment on all-cause mortality . Am J Epidemiol 1983;;117:566-574.
Multiple Risk Factor Intervention Trial Research Group:  Multiple Risk Factor Intervention Trial Research Group: Multiple Risk Factor Intervention Trial: Risk factor changes and mortality results . JAMA 1982;;248:1465-1477.
Borhani NO:  On behalf of the HDFP investigators: Relationship between baseline ECG abnormalities and intervention on blood pressure: The HDFP experience . The National Heart, Lung, and Blood Institute National Workshop on Implications of MRFIT, Bethesda, Md, Feb 19, 1983 .
 The Australian Therapeutic Trial in Mild Hypertension: Report by the Management Committee . Lancet 1980;;1:1261-1267.
 A Report by the Management Committee of the Australian Therapeutic Trial in Mild Hypertension: Untreated mild hypertension . Lancet 1982;;1:185-191.
 Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg . JAMA 1967;;202:1028-1034.
 Veterans Administration Cooperative Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg . JAMA 1970;;213:1143-1152.
Smith WM:  Treatment of mild hypertension: Results of a ten-year intervention trial: US Public Health Service Cooperative Study Group . Circ Res 1977;;40( (suppl 1) ): 198-1104.
 Hypertension Detection and Follow-up Program Cooperative Group: Regression of left ventricular hypertrophy with hypertensive therapy , abstracted. Circulation 1981;;64( (suppl 4) ):322.
 Hypertension Detection and Follow-up Program Cooperative Group: Effect of antihypertensive medication on left ventricular hypertrophy , abstracted. Am J Epidemiol 1982;;116:579.
Leonard AR, Igra A, Hawthorne A:  Status of high blood pressure control in California: A preliminary report of a statewide survey . Heart Lung 1981;;10:255.
Folsom AR, Luepker RV, Gillum RF, et al:  Improvement in hypertension detection and control from 1973-1974 to 1980-1981: The Minnesota Heart Survey Experience . JAMA 1983;;250:916-921.

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Kaplan NM:  Therapy for mild hypertension . JAMA 1983;;249:365-367.
McAlister NH:  Should we treat mild hypertension? JAMA 1983;; 365:379-382.
Pickering TG:  Treatment of mild hypertension and the reduction of cardiovascular mortality: The 'of or by' dilemma . JAMA 1983;;249:399-400.
 Hypertension Detection and Follow-up Program Cooperative Group: The effect of treatment on mortality in 'mild' hypertension: Results of the Hypertension Detection and Follow-up Program . N Engl J Med 1982;; 307:976-980.
Hardy RJ, Hawkins CM:  The impact of selected indices of antihypertensive treatment on all-cause mortality . Am J Epidemiol 1983;;117:566-574.
Multiple Risk Factor Intervention Trial Research Group:  Multiple Risk Factor Intervention Trial Research Group: Multiple Risk Factor Intervention Trial: Risk factor changes and mortality results . JAMA 1982;;248:1465-1477.
Borhani NO:  On behalf of the HDFP investigators: Relationship between baseline ECG abnormalities and intervention on blood pressure: The HDFP experience . The National Heart, Lung, and Blood Institute National Workshop on Implications of MRFIT, Bethesda, Md, Feb 19, 1983 .
 The Australian Therapeutic Trial in Mild Hypertension: Report by the Management Committee . Lancet 1980;;1:1261-1267.
 A Report by the Management Committee of the Australian Therapeutic Trial in Mild Hypertension: Untreated mild hypertension . Lancet 1982;;1:185-191.
 Veterans Administration Cooperative Study Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg . JAMA 1967;;202:1028-1034.
 Veterans Administration Cooperative Group on Antihypertensive Agents: Effects of treatment on morbidity in hypertension: II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg . JAMA 1970;;213:1143-1152.
Smith WM:  Treatment of mild hypertension: Results of a ten-year intervention trial: US Public Health Service Cooperative Study Group . Circ Res 1977;;40( (suppl 1) ): 198-1104.
 Hypertension Detection and Follow-up Program Cooperative Group: Regression of left ventricular hypertrophy with hypertensive therapy , abstracted. Circulation 1981;;64( (suppl 4) ):322.
 Hypertension Detection and Follow-up Program Cooperative Group: Effect of antihypertensive medication on left ventricular hypertrophy , abstracted. Am J Epidemiol 1982;;116:579.
Leonard AR, Igra A, Hawthorne A:  Status of high blood pressure control in California: A preliminary report of a statewide survey . Heart Lung 1981;;10:255.
Folsom AR, Luepker RV, Gillum RF, et al:  Improvement in hypertension detection and control from 1973-1974 to 1980-1981: The Minnesota Heart Survey Experience . JAMA 1983;;250:916-921.
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