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August 19, 1983, Vol 250, No. 7 >
ARTICLE | August 19, 1983

Minocycline Treatment of Pulmonary Nocardiosis FREE

Eskild A. Petersen, MD; Martha L. Nash, RN; Robert B. Mammana, MD; Jack G. Copeland, MD
[+] Author Affiliations

Reprint requests to Section of Infectious Disease, Arizona Health Sciences Center, 1501 N Campbell, Tucson, AZ 85724 (Dr Petersen).


JAMA. 1983;250(7):930-932. doi:10.1001/jama.1983.03340070036023
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References

Minocycline hydrochloride was used to treat pulmonary infections with Nocardia asteroides in five cardiac allograft recipients. In three patients, minocycline was successfully used as the only antinocardial agent. Two other patients were found to have leukopenia after initial therapy with sulfisoxazole. These two patients were subsequently treated with minocycline. The clinical success with minocycline in these highly immunosuppressed patients suggests that minocycline is an effective antinocardial agent. These data did not allow any conclusion regarding which drug, minocycline or sulfisoxazole, is superior in the treatment of this disease.

(JAMA 1983;250:930-932)

REFERENCES

1 +
Krick JA, Stinson EB, Remington JS:  Nocardia infection in heart transplant patients . Ann Intern Med 1975;;82:18-26.
2 +
Stevens DA, Pier AC, Beaman BL, et al:  Laboratory evaluation of an outbreak of nocardiosis in immunocompromised hosts . Am J Med 1981;;71:928-934.
3 +
Curry WA:  Human nocardiosis: A clinical review with selected case reports . Arch Intern Med 1980;;140:818-826.
4 +
Palmer DL, Harvey RL, Wheeler JK:  Diagnostic and therapeutic considerations in Nocardia asteroides infection . Medicine 1974;;53:391-401.
5 +
Simpson GL, Stinson EB, Egger MJ, et al:  Nocardial infections in the immunocompromised host: A detailed study in a defined population . Rev Infect Dis 1981;;3:492-507.
6 +
Bach MC, Monaco AP, Finland M:  Pulmonary nocardiosis: Therapy with minocycline and with erythromycin plus ampicillin . JAMA 1973;; 224:1378-1381.
7 +
Wren MV, Savage AM, Alford RH:  Apparent cure of intracranial Nocardia asteroides infection by minocycline . Arch Intern Med 1979;; 139:249-250.
8 +
Ochiai T, Amemiya H, Watanabe K, et al:  Successful treatment of Nocardia asteroides infection with minocycline in kidney transplant patients . Jpn J Surg 1978;;8:138-144.
9 +
Bach MC, Sabath LD, Finland M:  Susceptibility of Nocardia asteroides to 45 antimicrobial agents in vitro . Antimicrob Agents Chemother 1973;;3:1-8.
10 +
Wallace RJ Jr, Septimus EJ, Musher DM, et al:  Disk diffusion susceptibility testing of Nocardia species . J Infect Dis 1977;;135:568-576.
11 +
Steigbigel NH, Reed CW, Finland M:  Absorption and excretion of five tetracycline analogues in normal young men . Am J Med Sci 1968;;255:296-312.
12 +
Fanning WL, Gump DW:  Distressing side-effects of minocycline hydrochloride . Arch Intern Med 1976;;136:761-762.
13 +
Jacobson JA, Daniel B:  Vestibular reactions associated with minocycline . Antimicrob Agents Chemother 1975;;8:453-456.
14 +
Williams DN, Laughlin LW, Lee YH:  Minocycline: Possible vestibular side-effects . Lancet 1974;;2:744-746.
15 +
Brogden RN, Speight TM, Avery GS:  Minocycline: A review of its antibacterial and pharmacokinetic properties and therapeutic use . Drugs 1975;;9:251-291.
16 +
Lauschner EA:  Klinomycin: Ein neues Breitbandantibiotikum: Ergebnisse eines Großversuches in Klinik und Praxis . MMW 1973;:115:2156-2160.
17 +
Mandell GL, Sande MA:  Antimicrobial agents: Sulfonamides , in Gilman AG, Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 6. New York, Macmillan Publishing Co Inc, 1980;, pp 1106-1116.
18 +
Benitz KF, Roberts GKS, Yusa A:  Morphologic effects of minocycline in laboratory animals . Toxicol Appl Pharmacol 1967;;11:150-170.
19 +
Attwood H, Dennett X:  A black thyroid and minocycline treatment . Br Med J 1976;; 2:1109-1110.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Krick JA, Stinson EB, Remington JS:  Nocardia infection in heart transplant patients . Ann Intern Med 1975;;82:18-26.
2 +
Stevens DA, Pier AC, Beaman BL, et al:  Laboratory evaluation of an outbreak of nocardiosis in immunocompromised hosts . Am J Med 1981;;71:928-934.
3 +
Curry WA:  Human nocardiosis: A clinical review with selected case reports . Arch Intern Med 1980;;140:818-826.
4 +
Palmer DL, Harvey RL, Wheeler JK:  Diagnostic and therapeutic considerations in Nocardia asteroides infection . Medicine 1974;;53:391-401.
5 +
Simpson GL, Stinson EB, Egger MJ, et al:  Nocardial infections in the immunocompromised host: A detailed study in a defined population . Rev Infect Dis 1981;;3:492-507.
6 +
Bach MC, Monaco AP, Finland M:  Pulmonary nocardiosis: Therapy with minocycline and with erythromycin plus ampicillin . JAMA 1973;; 224:1378-1381.
7 +
Wren MV, Savage AM, Alford RH:  Apparent cure of intracranial Nocardia asteroides infection by minocycline . Arch Intern Med 1979;; 139:249-250.
8 +
Ochiai T, Amemiya H, Watanabe K, et al:  Successful treatment of Nocardia asteroides infection with minocycline in kidney transplant patients . Jpn J Surg 1978;;8:138-144.
9 +
Bach MC, Sabath LD, Finland M:  Susceptibility of Nocardia asteroides to 45 antimicrobial agents in vitro . Antimicrob Agents Chemother 1973;;3:1-8.
10 +
Wallace RJ Jr, Septimus EJ, Musher DM, et al:  Disk diffusion susceptibility testing of Nocardia species . J Infect Dis 1977;;135:568-576.
11 +
Steigbigel NH, Reed CW, Finland M:  Absorption and excretion of five tetracycline analogues in normal young men . Am J Med Sci 1968;;255:296-312.
12 +
Fanning WL, Gump DW:  Distressing side-effects of minocycline hydrochloride . Arch Intern Med 1976;;136:761-762.
13 +
Jacobson JA, Daniel B:  Vestibular reactions associated with minocycline . Antimicrob Agents Chemother 1975;;8:453-456.
14 +
Williams DN, Laughlin LW, Lee YH:  Minocycline: Possible vestibular side-effects . Lancet 1974;;2:744-746.
15 +
Brogden RN, Speight TM, Avery GS:  Minocycline: A review of its antibacterial and pharmacokinetic properties and therapeutic use . Drugs 1975;;9:251-291.
16 +
Lauschner EA:  Klinomycin: Ein neues Breitbandantibiotikum: Ergebnisse eines Großversuches in Klinik und Praxis . MMW 1973;:115:2156-2160.
17 +
Mandell GL, Sande MA:  Antimicrobial agents: Sulfonamides , in Gilman AG, Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 6. New York, Macmillan Publishing Co Inc, 1980;, pp 1106-1116.
18 +
Benitz KF, Roberts GKS, Yusa A:  Morphologic effects of minocycline in laboratory animals . Toxicol Appl Pharmacol 1967;;11:150-170.
19 +
Attwood H, Dennett X:  A black thyroid and minocycline treatment . Br Med J 1976;; 2:1109-1110.

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