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August 5, 1983, Vol 250, No. 5 >
ARTICLE | August 5, 1983

Radioimmunodetection of Prostatic Cancer: Title and subTitle BreakIn Vivo Use of Radioactive Antibodies Against Prostatic Acid Phosphatase for Diagnosis and Detection of Prostatic Cancer by Nuclear Imaging FREE

David M. Goldenberg, ScD, MD; Frank H. DeLand, MD; Sidney J. Bennett, PhD; F. James Primus, PhD; M. Owens Nelson, MD; Robert C. Flanigan, MD; J. William McRoberts, MD; Andrew W. Bruce, MD; Donald E. Mahan, PhD
[+] Author Affiliations

Reprint requests to Division of Experimental Pathology, Room 243, Research Building 3, University of Kentucky, Lexington, KY 40536 (Dr Goldenberg).


JAMA. 1983;250(5):630-635. doi:10.1001/jama.1983.03340050042026
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References

Radioimmunodetection (RAID) of prostatic cancer is done by injecting131I-labeled rabbit antibody IgG against prostatic acid phosphatase (PAP) and performing total-body photoscans with a gamma scintillation camera. Of two patients tested, the PAP RAID scintiscans located the primary or recurrent prostatic cancers in both and showed no disease in the lungs of the patient shown subsequently to have lung cancer. The lung tumor nodules showing anti-PAP IgG accretion were assumed to be of prostatic cancer origin, since one of the original tumors removed from this patient's other lung a year earlier stained for PAP by immunohistochemistry. This study showed that PAP RAID can locate primary and metastatic tumors of prostatic origin.

(JAMA 1983;250:630-635)

REFERENCES

1 +
 Third National Cancer Survey: Incidence data . Natl Cancer Inst Monogr 1975;;41:1-454 (publication [NIH] 75-787).
2 +
Axtell LM, Ardyce JA, Myers MH (eds): Cancer Patient Survival Report No. 5 . Bethesda, Md, US Dept of Health, Education, and Welfare, 1976;.
3 +
Halbert B, Schmalhorst WR:  Carcinoma of the prostate in patients 70 to 79 years old . Cancer 1966;;19:695-698.
4 +
Hirst AE Jr, Bergman RT:  Carcinoma of the prostate in men 80 or more years old . Cancer 1954;;7:136-141.
5 +
Schmalhorst WR, Halpert B:  Carcinoma of the prostate gland in patients more than 80 years old . Am J Clin Pathol 1964;;42:170-173.
6 +
Gutman EB, Sproul EB, Gutman AB:  Increased phosphatase activity of bone at site of osteoplastic metastases secondary to carcinoma of prostate gland . J Urol 1936;;28:485-495.
7 +
Yam LT:  Clinical significance of the human acid phosphatase: A review . Am J Med 1974;; 56:606-616.
8 +
Chu TM:  Serum acid phosphohydrolase (phosphatase) and ribonuclease in diagnosis of prostatic cancer . Antibiot Chemother 1978;;22:98-104.
9 +
Mahan DE, Doctor BP:  A radioimmune assay for human prostatic acid phosphatase levels in prostatic disease . Clin Biochem 1979;; 12:10-17.
10 +
Griffiths JC:  Prostate-specific acid phosphatase: Re-evaluation of radioimmunoassay in diagnosing prostatic disease . Clin Chem 1980;; 26:433-436.
11 +
Foti AG, Cooper JF, Herschman H, et al:  Detection of prostatic cancer by solid-phase radioimmunoassay of serum prostatic acid phosphatase . N Engl J Med 1977;;297:1357-1361.
12 +
Bruce AW, Mahan DE, Morales A, et al:  An objective look at acid phosphatase determinations: Comparison of biochemical and immunological methods . Br J Urol 1979;;51:213-217.
13 +
Bruce AW, Mahan DE, Sullivan LD, et al:  The significance of prostatic acid phosphatase in adenocarcinoma of the prostate . J Urol 1981;; 125:357-360.
14 +
Gold DV, Goldenberg DM:  Antigens associated with human solid tumors , in Sell S (ed): Cancer Markers: Developmental and Diagnostic Significance . New York, Humana Press, 1979;, pp 329-369.
15 +
Goldenberg DM, DeLand F, Kim E, et al:  Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning . N Engl J Med 1978;;298:1384-1388.
16 +
Goldenberg DM, Kim EE, DeLand FH, et al:  Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen . Cancer Res 1980;;40:2984-2992.
17 +
Goldenberg DM, Kim EE, DeLand F, et al:  Clinical studies on the radioimmunodetection of tumors containing α-fetoprotein . Cancer 1980;; 45:2500-2505.
18 +
Goldenberg DM, Kim EE, DeLand FH, et al:  Radioimmunodetection of cancer using radioactive antibodies to human chorionic gonadotropin . Science 1980;;208:1284-1286.
19 +
Javadpour N, Kim EE, DeLand FH, et al:  The role of radioimmunodetection in the management of testicular cancer . JAMA 1981;;246:45-49.
20 +
Goldenberg DM, Kim EE, DeLand FH:  Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases . Proc Natl Acad Sci USA 1981;;78:7754-7758.
21 +
DeLand FH, Kim EE, Casper S, et al:  In vivo radioimmunodetection of occult recurrent colonic carcinoma . AJR 1982;;138:145-148.
22 +
Goldenberg DM, Kim EE, Bennett SJ, et al:  CEA radioimmunodetection in the evaluation of colorectal cancer and in the detection of occult neoplasms . Gastroenterology 1983;;84:524-532.
23 +
Guesdon JL, Ternynck T, Avrameas S:  The use of avidin-biotin interaction in immunoenzymatic techniques . J Histochem Cytochem 1979;;27:1131-1139.
24 +
Primus FJ, Goldenberg DM:  Functional histopathology of cancer: A review of immunoenzyme histochemistry . Methods Cancer Res 1982;;20:139-182.
25 +
Jöbsis AC, DeVries GP, Anholt RR, et al:  Demonstration of the prostatic origin of metastases: An immunohistochemical method for formalin-fixed embedded tissue . Cancer 1978;; 41:1788-1793.
26 +
Mahan DE, Bruce AW, Manley PM, et al:  Immunohistochemical evaluation of prostatic carcinoma before and after radiotherapy . J Urol 1980;;124:488-491.
27 +
DeLand FH, Kim EE, Simmons G, et al:  Imaging approach in radioimmunodetection . Cancer Res 1980;;40:3046-3049.
28 +
Aumiller G, Pohl C, van Etten RL, et al:  Immunohistochemistry of acid phosphatase in the human prostate: Normal and pathologic . Virchows Arch Cell Pathol 1981;;35:249-262.
29 +
Li CY, Lam WKW, Yam LT:  Immunohistochemical diagnosis of prostatic cancer with metastasis . Cancer 1980;;46:706-712.
30 +
Nadji M, Tabei SZ, Castro A, et al:  Prostatic origin of tumors: An immunohistochemical study . Am J Clin Pathol 1980;;73:736-739.
31 +
Nystrom JS, Weiner JM, Wolf RM, et al:  Identifying the primary site in metastatic cancer of unknown origin: Inadequacy of roentgenographic procedures . JAMA 1979;;241:381-383.
32 +
DeLand FH, Kim EE, Corgan RL, et al:  Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer . J Nucl Med 1979;;20:1243-1279.
33 +
DeLand FH, Kim EE, Goldenberg DM:  Lymphoscintigraphy with radionuclide-labeled antibodies to carcinoembryonic antigen . Cancer Res 1980;;40:2997-3000.
34 +
Papsidero LD, Wang MC, Valenzuela LA, et al:  A prostate antigen in sera of prostatic cancer patients . Cancer Res 1980;;40:2428-2432.
35 +
Frankel AE, Rouse RV, Herzenberg LA:  Human prostate specific and shared differentiation antigens defined by monoclonal antibodies . Proc Natl Acad Sci USA 1982;;79:903-907.
36 +
Ware JL, Paulson DF, Parks SF, et al:  Production of monoclonal antibody αPro3 recognizing a human prostatic carcinoma antigen . Cancer Res 1982;;42:1215-1222.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
 Third National Cancer Survey: Incidence data . Natl Cancer Inst Monogr 1975;;41:1-454 (publication [NIH] 75-787).
2 +
Axtell LM, Ardyce JA, Myers MH (eds): Cancer Patient Survival Report No. 5 . Bethesda, Md, US Dept of Health, Education, and Welfare, 1976;.
3 +
Halbert B, Schmalhorst WR:  Carcinoma of the prostate in patients 70 to 79 years old . Cancer 1966;;19:695-698.
4 +
Hirst AE Jr, Bergman RT:  Carcinoma of the prostate in men 80 or more years old . Cancer 1954;;7:136-141.
5 +
Schmalhorst WR, Halpert B:  Carcinoma of the prostate gland in patients more than 80 years old . Am J Clin Pathol 1964;;42:170-173.
6 +
Gutman EB, Sproul EB, Gutman AB:  Increased phosphatase activity of bone at site of osteoplastic metastases secondary to carcinoma of prostate gland . J Urol 1936;;28:485-495.
7 +
Yam LT:  Clinical significance of the human acid phosphatase: A review . Am J Med 1974;; 56:606-616.
8 +
Chu TM:  Serum acid phosphohydrolase (phosphatase) and ribonuclease in diagnosis of prostatic cancer . Antibiot Chemother 1978;;22:98-104.
9 +
Mahan DE, Doctor BP:  A radioimmune assay for human prostatic acid phosphatase levels in prostatic disease . Clin Biochem 1979;; 12:10-17.
10 +
Griffiths JC:  Prostate-specific acid phosphatase: Re-evaluation of radioimmunoassay in diagnosing prostatic disease . Clin Chem 1980;; 26:433-436.
11 +
Foti AG, Cooper JF, Herschman H, et al:  Detection of prostatic cancer by solid-phase radioimmunoassay of serum prostatic acid phosphatase . N Engl J Med 1977;;297:1357-1361.
12 +
Bruce AW, Mahan DE, Morales A, et al:  An objective look at acid phosphatase determinations: Comparison of biochemical and immunological methods . Br J Urol 1979;;51:213-217.
13 +
Bruce AW, Mahan DE, Sullivan LD, et al:  The significance of prostatic acid phosphatase in adenocarcinoma of the prostate . J Urol 1981;; 125:357-360.
14 +
Gold DV, Goldenberg DM:  Antigens associated with human solid tumors , in Sell S (ed): Cancer Markers: Developmental and Diagnostic Significance . New York, Humana Press, 1979;, pp 329-369.
15 +
Goldenberg DM, DeLand F, Kim E, et al:  Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning . N Engl J Med 1978;;298:1384-1388.
16 +
Goldenberg DM, Kim EE, DeLand FH, et al:  Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen . Cancer Res 1980;;40:2984-2992.
17 +
Goldenberg DM, Kim EE, DeLand F, et al:  Clinical studies on the radioimmunodetection of tumors containing α-fetoprotein . Cancer 1980;; 45:2500-2505.
18 +
Goldenberg DM, Kim EE, DeLand FH, et al:  Radioimmunodetection of cancer using radioactive antibodies to human chorionic gonadotropin . Science 1980;;208:1284-1286.
19 +
Javadpour N, Kim EE, DeLand FH, et al:  The role of radioimmunodetection in the management of testicular cancer . JAMA 1981;;246:45-49.
20 +
Goldenberg DM, Kim EE, DeLand FH:  Human chorionic gonadotropin radioantibodies in the radioimmunodetection of cancer and for disclosure of occult metastases . Proc Natl Acad Sci USA 1981;;78:7754-7758.
21 +
DeLand FH, Kim EE, Casper S, et al:  In vivo radioimmunodetection of occult recurrent colonic carcinoma . AJR 1982;;138:145-148.
22 +
Goldenberg DM, Kim EE, Bennett SJ, et al:  CEA radioimmunodetection in the evaluation of colorectal cancer and in the detection of occult neoplasms . Gastroenterology 1983;;84:524-532.
23 +
Guesdon JL, Ternynck T, Avrameas S:  The use of avidin-biotin interaction in immunoenzymatic techniques . J Histochem Cytochem 1979;;27:1131-1139.
24 +
Primus FJ, Goldenberg DM:  Functional histopathology of cancer: A review of immunoenzyme histochemistry . Methods Cancer Res 1982;;20:139-182.
25 +
Jöbsis AC, DeVries GP, Anholt RR, et al:  Demonstration of the prostatic origin of metastases: An immunohistochemical method for formalin-fixed embedded tissue . Cancer 1978;; 41:1788-1793.
26 +
Mahan DE, Bruce AW, Manley PM, et al:  Immunohistochemical evaluation of prostatic carcinoma before and after radiotherapy . J Urol 1980;;124:488-491.
27 +
DeLand FH, Kim EE, Simmons G, et al:  Imaging approach in radioimmunodetection . Cancer Res 1980;;40:3046-3049.
28 +
Aumiller G, Pohl C, van Etten RL, et al:  Immunohistochemistry of acid phosphatase in the human prostate: Normal and pathologic . Virchows Arch Cell Pathol 1981;;35:249-262.
29 +
Li CY, Lam WKW, Yam LT:  Immunohistochemical diagnosis of prostatic cancer with metastasis . Cancer 1980;;46:706-712.
30 +
Nadji M, Tabei SZ, Castro A, et al:  Prostatic origin of tumors: An immunohistochemical study . Am J Clin Pathol 1980;;73:736-739.
31 +
Nystrom JS, Weiner JM, Wolf RM, et al:  Identifying the primary site in metastatic cancer of unknown origin: Inadequacy of roentgenographic procedures . JAMA 1979;;241:381-383.
32 +
DeLand FH, Kim EE, Corgan RL, et al:  Axillary lymphoscintigraphy by radioimmunodetection of carcinoembryonic antigen in breast cancer . J Nucl Med 1979;;20:1243-1279.
33 +
DeLand FH, Kim EE, Goldenberg DM:  Lymphoscintigraphy with radionuclide-labeled antibodies to carcinoembryonic antigen . Cancer Res 1980;;40:2997-3000.
34 +
Papsidero LD, Wang MC, Valenzuela LA, et al:  A prostate antigen in sera of prostatic cancer patients . Cancer Res 1980;;40:2428-2432.
35 +
Frankel AE, Rouse RV, Herzenberg LA:  Human prostate specific and shared differentiation antigens defined by monoclonal antibodies . Proc Natl Acad Sci USA 1982;;79:903-907.
36 +
Ware JL, Paulson DF, Parks SF, et al:  Production of monoclonal antibody αPro3 recognizing a human prostatic carcinoma antigen . Cancer Res 1982;;42:1215-1222.

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