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ARTICLE |

Diagnosis of Brain Death FREE

Joanne Lynn, MD
[+] Author Affiliations

Edited by John D. Archer, MD, Senior Editor.


JAMA. 1983;250(5):612-612. doi:10.1001/jama.1983.03340050024010
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To the Editor.—  Radionuclide cerebral imaging (RCI) has been well established as a confirmation of brain death.1-3 However, the proved utility of the procedure is overstated in the recent article by Schwartz et al (1983; 249:246), largely because it confuses cerebral blood flow with intracranial. Also, the authors overstate the importance of demonstrating correlation between two tests in a selected population of patients.Documentation of absent intracranial blood flow can at present only be achieved by four-vessel contrast angiography, which examines blood flow to both the cerebrum and the posterior fossa. This study, repeated to show persistence for a period (ten minutes is recommended), is unequivocal evidence of "irreversible cessation of all functions of the entire brain"—brain death—even if circumstances preclude determination of cause or a comprehensive neurological examination.However, the same cannot be said for a test such as RCI that evaluates only cerebral blood flow, not posterior

REFERENCES

 Guidelines for the determination of death: Report of the medical consultants on the diagnosis of death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research . JAMA 1981;;246:2184-2186.
Korein J, Braunstein P, George A, et al:  Brain death: I. Angiographic correlation with the radioisotopic bolus technique for evaluation of critical deficit of cerebral blood flow . Ann Neurol 1977;;2:195-205.
Goodman MJ, Heck LL:  Confirmation of brain death at bedside by isotope angiography . JAMA 1977;; 238:966-968.
Schafer JA, Caronna JJ:  Duration of apnea needed to confirm brain death . Neurology 1978;;28:661-666.
 A definition of irreversible coma: Report of the Ad Hoc Committee of the Harvard Medical School to examine the definition of brain death . JAMA 1968;; 205:337-340.

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 Guidelines for the determination of death: Report of the medical consultants on the diagnosis of death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research . JAMA 1981;;246:2184-2186.
Korein J, Braunstein P, George A, et al:  Brain death: I. Angiographic correlation with the radioisotopic bolus technique for evaluation of critical deficit of cerebral blood flow . Ann Neurol 1977;;2:195-205.
Goodman MJ, Heck LL:  Confirmation of brain death at bedside by isotope angiography . JAMA 1977;; 238:966-968.
Schafer JA, Caronna JJ:  Duration of apnea needed to confirm brain death . Neurology 1978;;28:661-666.
 A definition of irreversible coma: Report of the Ad Hoc Committee of the Harvard Medical School to examine the definition of brain death . JAMA 1968;; 205:337-340.
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