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December 16, 1983, Vol 250, No. 23 >
ARTICLE | December 16, 1983

Weight Change Since Age 18 Years in 30- to 55-Year-Old Whites and Blacks: Title and subTitle BreakAssociations With Lipid Values, Lipoprotein Levels, and Blood Pressure FREE

Philip Khoury, MS; John A. Morrison, PhD; Margot J. Mellies, MD; Charles J. Glueck, MD
[+] Author Affiliations

Reprint requests to General Clinical Research Center, University Hospital, Mail Location 767, Cincinnati, OH 45267 (Dr Glueck).


JAMA. 1983;250(23):3179-3187. doi:10.1001/jama.1983.03340230031023
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References

To assess associations between current weight, weight at age 18 years, and weight change from age 18 years to ages 30 to 55 years with current levels of plasma cholesterol (C), high- and low-density lipoprotein C (HDLC and LDLC), triglycerides (TG), and systolic and diastolic BP (SBP and DBP), we calculated weight change from self-reported weight at age 18 years and measured weight at ages 30 to 55 years in 308 white and 69 black subjects in a random recall group and 244 whites and 66 blacks in a hyperlipidemic recall group in the Princeton School Study. In randomrecall-group whites, mean weight gain over time was greater in men than in women; black women had greater weight gain than black men, and nearly twice the weight gain of white women. Current weight and/or weight gain from age 18 years to ages 30 to 55 years in whites were inversely associated with HDLC level and positively associated with TG level, SBP, and DBP. Similar, but less consistent and significant, trends were observed for blacks. Although weight at age 18 years had no consistent independent explanatory relationship to C, TG, HDLC, and LDLC values, random-recall-group white men who were in the lowest quartile for weight at age 18 years had current levels of C, TG, SBP, and DBP that were all lower than those observed in white men who had been in the upper quartile of weight at age 18 years. Atherogenic increments in TG levels, SBP, and DBP from age 18 years to ages 30 to 55 years are a function, in part, of weight gain during these years.

(JAMA 1983;250:3179-3187)

REFERENCES

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Keen H, Thomas BJ, Jarrett RJ:  Obesity and cardiovascular risk . Int J Obesity 1982;; 6( (suppl 1) ):83-89.
2 +
Build and Pressure Study . Chicago, Society of Actuaries, 1959;, vol 1, pp 1-268.
3 +
Abraham S, Nordsieck M:  Relationship of excess weight in children and adults . Public Health Rep 1960;;75:263-273.
4 +
Rabkin S, Mathewson FAL, Hsu P-H:  Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: The Manitoba study . Am J Cardiol 1977;;39:452-458.
5 +
Lew EA, Garfinkel L:  Variations in mortality by weight among 750,000 men and women . J Chronic Dis 1979;;32:563-576.
6 +
Gillum RF, Grant CT:  Coronary heart-disease in black populations: II. Risk-factors . Am Heart J 1982;;104:852-864.
7 +
Ashley FW Jr, Kannel WB:  Relations of weight change to changes in atherogenic traits: The Framingham study . J Chronic Dis 1974;; 27:103-114.
8 +
Connor WE, Cerqueira MT, Connor RW, et al:  The plasma lipids, lipoproteins, and diet of the Tarahumara Indians of Mexico . Am J Clin Nutr 1978;;31:1131-1143.
9 +
Heiss G, Tamir I, Davis CE, et al:  Lipoprotein cholesterol distributions in selected North American populations: The Lipid Research Clinics Program prevalence study . Circulation 1980;; 61:302-315.
10 +
Feinleib M, Garrison JR, Stallones L:  A comparison of blood pressure, total cholesterol, and cigarette smoking in patients in 1950 and their children in 1979 . Am J Epidemiol 1979;; 110:291-303.
11 +
Goldbourt U, Medallie JH:  High density lipoprotein cholesterol and the incidence of coronary heart disease: The Israeli ischemic heart disease study . Am J Epidemiol 1979;; 109:296-308.
12 +
The Lipid Research Clinics Population Studies Data Book: I. The Prevalence Study , US Dept of Health, Education, and Welfare publication (NIH) 80-1527. Bethesda, Md, National Institutes of Health, 1980;.
13 +
Laskarzewski P, Morrison JA, Mellies MJ, et al:  Relationships of measurements of body mass to plasma lipoproteins in schoolchildren and adults . Am J Epidemiol 1980;;111:395-406.
14 +
Gartside PS, Morrison JA, Khoury P, et al:  Clustering and interrelationships of high, low, and very low density lipoproteins in hypolipidemic schoolchildren and adults: The Cincinnati Lipid Research Clinic's Princeton School Population Study . Prev Med 1981;;10:1-14.
15 +
Khoury P, Morrison JA, Kelly K, et al:  Clustering and interrelationships of coronary heart disease risk factors in schoolchildren, ages 6-19 . Am J Epidemiol 1980;;112:524-538.
16 +
Laskarzewski P, Morrison JA, Horvitz R, et al:  The relationship of parental history of myocardial infarction, hypertension, diabetes, and stroke to coronary heart disease risk factors in their adult progeny . Am J Epidemiol 1981;; 113:290-307.
17 +
Morrison JA, Kelly KA, Mellies MJ, et al:  Parent-child associations at upper and lower ranges of plasma cholesterol and triglyceride . Pediatrics 1978;;62:468-478.
18 +
Morrison JA, Khoury P, Laskarzewski P, et al:  Hyperalphalipoproteinemia in hypercholesterolemic adults and children . Trans Assoc Am Physicians 1980;;93:230-243.
19 +
Lipid Research Clinics Program: Manual of Laboratory Operations: I. Lipid and Lipoprotein Analysis, US Dept of Health, Education, and Welfare publication (NIH) 75-628. Government Printing Office, 1974.
20 +
Morrison JA, Khoury P, Kelly K, et al:  Studies of blood pressure in school children (ages 6-19) and their parents in an integrated suburban school district . Am J Epidemiol 1980;; 3:156-165.
21 +
Lipid Research Clinics Program: Reference Manual for Lipid Research Clinics Program Prevalence Study . Chapel Hill, NC, Central Patient Registry and Coordinating Center, University of North Carolina, 1972;.
22 +
Barr AJ, Goodnight JH, Sall JP, et al: A User's Guide to SAS-76 . Raleigh, NC, SAS Institute Inc, 1976;.
23 +
Snedecor GW, Cochran WG: Statistical Methods , ed 6. Ames, Iowa, Iowa State University Press, 1967;.
24 +
Berenson GS: Cardiovascular Risk Factors in Children . Oxford, England, Oxford University Press, 1980;, pp 1-451.
25 +
Streja DA, Boyko E, Rabkin S:  Predictors of outcome in a risk factor intervention trial using behavior modification . Prev Med 1982;; 11:291-303.
26 +
Dawber TF, Moore FE, Mann GV:  Coronary heart disease in the Framingham Study: A symposium on measuring the risk of coronary heart disease in adult population groups . Am J Public Health 1957;;47:4-24.
27 +
Shurtleff D:  Some characteristics related to the incidence of cardiovascular disease and death , in Kannel WB, Gordon T (eds): The Framingham Study: Eighteen-Year Follow-up , publication 74-599. National Institutes of Health, 1974;, pp 83-124.
28 +
Kesteloot H, Lee CS, Park HM, et al:  A comparative study of serum lipids between Belgium and Korea . Circulation 1982;;65:795-799.
29 +
O'Dea KO, Spargo RM, Nestel PJ:  Impact of westernization of carbohydrate and lipid metabolism in Australian aborigines . Diabetologia 1982;;22:148-153.
30 +
Albrink MJ, Meigs JW, Granoff MA:  Weight gain and serum triglycerides in normal men . N Engl J Med 1962;;266:484-489.
31 +
Gillum RF, Taylor HL, Brozek J:  Blood lipids in young men followed 32 years . J Chronic Dis 1982;;35:635-641.
32 +
Glueck CJ, Gartside P, Laskarzewski P, et al:  High density lipoprotein cholesterol in blacks and whites: Potential ramifications for coronary heart disease . Am Heart J , in press.
33 +
Body weight, stature, and sitting height: White and Negro youths 12-17 years, United States. Vital Health Stat 11, 1973.
34 +
Sims EAH, Goldman RF, Gluch CM, et al:  Experimental obesity in men . Trans Assoc Am Physicians 1968;;81:153-170.
35 +
Matter S, Weltman A, Stamford BA:  Body fat content and serum lipid levels . J Am Diet Assoc 1980;;77:149-152.
36 +
Morrison JA, deGroot I, Kelly KA, et al:  Black-white differences in plasma lipoproteins in Cincinnati school children (one-to-one pair-matched by total plasma cholesterol, sex, and age) . Metabolism 1979;;28:241-245.
37 +
Morrison JA, deGroot I, Kelly KA, et al:  Black-white differences in plasma lipids and lipoproteins in adults: The Cincinnati Lipid Research Clinic population study . Prev Med 1979;;8:34-39.
38 +
Garn SM, Bailey SM, Higgens ITT:  Effects of socioeconomic status, family line, and living together on fatness and obesity , in Lauer RM, Shekelle RB (eds): Childhood Prevention of Atherosclerosis and Hypertension . New York, Raven Press, 1980;, pp 187-204.
39 +
Khoury P, Morrison JA, Laskarzewski PM, et al:  Parent-offspring and sibling body mass index associations during and after sharing of common household environments: The Princeton school district family study . Metabolism 1983;; 32:82-89.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Keen H, Thomas BJ, Jarrett RJ:  Obesity and cardiovascular risk . Int J Obesity 1982;; 6( (suppl 1) ):83-89.
2 +
Build and Pressure Study . Chicago, Society of Actuaries, 1959;, vol 1, pp 1-268.
3 +
Abraham S, Nordsieck M:  Relationship of excess weight in children and adults . Public Health Rep 1960;;75:263-273.
4 +
Rabkin S, Mathewson FAL, Hsu P-H:  Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: The Manitoba study . Am J Cardiol 1977;;39:452-458.
5 +
Lew EA, Garfinkel L:  Variations in mortality by weight among 750,000 men and women . J Chronic Dis 1979;;32:563-576.
6 +
Gillum RF, Grant CT:  Coronary heart-disease in black populations: II. Risk-factors . Am Heart J 1982;;104:852-864.
7 +
Ashley FW Jr, Kannel WB:  Relations of weight change to changes in atherogenic traits: The Framingham study . J Chronic Dis 1974;; 27:103-114.
8 +
Connor WE, Cerqueira MT, Connor RW, et al:  The plasma lipids, lipoproteins, and diet of the Tarahumara Indians of Mexico . Am J Clin Nutr 1978;;31:1131-1143.
9 +
Heiss G, Tamir I, Davis CE, et al:  Lipoprotein cholesterol distributions in selected North American populations: The Lipid Research Clinics Program prevalence study . Circulation 1980;; 61:302-315.
10 +
Feinleib M, Garrison JR, Stallones L:  A comparison of blood pressure, total cholesterol, and cigarette smoking in patients in 1950 and their children in 1979 . Am J Epidemiol 1979;; 110:291-303.
11 +
Goldbourt U, Medallie JH:  High density lipoprotein cholesterol and the incidence of coronary heart disease: The Israeli ischemic heart disease study . Am J Epidemiol 1979;; 109:296-308.
12 +
The Lipid Research Clinics Population Studies Data Book: I. The Prevalence Study , US Dept of Health, Education, and Welfare publication (NIH) 80-1527. Bethesda, Md, National Institutes of Health, 1980;.
13 +
Laskarzewski P, Morrison JA, Mellies MJ, et al:  Relationships of measurements of body mass to plasma lipoproteins in schoolchildren and adults . Am J Epidemiol 1980;;111:395-406.
14 +
Gartside PS, Morrison JA, Khoury P, et al:  Clustering and interrelationships of high, low, and very low density lipoproteins in hypolipidemic schoolchildren and adults: The Cincinnati Lipid Research Clinic's Princeton School Population Study . Prev Med 1981;;10:1-14.
15 +
Khoury P, Morrison JA, Kelly K, et al:  Clustering and interrelationships of coronary heart disease risk factors in schoolchildren, ages 6-19 . Am J Epidemiol 1980;;112:524-538.
16 +
Laskarzewski P, Morrison JA, Horvitz R, et al:  The relationship of parental history of myocardial infarction, hypertension, diabetes, and stroke to coronary heart disease risk factors in their adult progeny . Am J Epidemiol 1981;; 113:290-307.
17 +
Morrison JA, Kelly KA, Mellies MJ, et al:  Parent-child associations at upper and lower ranges of plasma cholesterol and triglyceride . Pediatrics 1978;;62:468-478.
18 +
Morrison JA, Khoury P, Laskarzewski P, et al:  Hyperalphalipoproteinemia in hypercholesterolemic adults and children . Trans Assoc Am Physicians 1980;;93:230-243.
19 +
Lipid Research Clinics Program: Manual of Laboratory Operations: I. Lipid and Lipoprotein Analysis, US Dept of Health, Education, and Welfare publication (NIH) 75-628. Government Printing Office, 1974.
20 +
Morrison JA, Khoury P, Kelly K, et al:  Studies of blood pressure in school children (ages 6-19) and their parents in an integrated suburban school district . Am J Epidemiol 1980;; 3:156-165.
21 +
Lipid Research Clinics Program: Reference Manual for Lipid Research Clinics Program Prevalence Study . Chapel Hill, NC, Central Patient Registry and Coordinating Center, University of North Carolina, 1972;.
22 +
Barr AJ, Goodnight JH, Sall JP, et al: A User's Guide to SAS-76 . Raleigh, NC, SAS Institute Inc, 1976;.
23 +
Snedecor GW, Cochran WG: Statistical Methods , ed 6. Ames, Iowa, Iowa State University Press, 1967;.
24 +
Berenson GS: Cardiovascular Risk Factors in Children . Oxford, England, Oxford University Press, 1980;, pp 1-451.
25 +
Streja DA, Boyko E, Rabkin S:  Predictors of outcome in a risk factor intervention trial using behavior modification . Prev Med 1982;; 11:291-303.
26 +
Dawber TF, Moore FE, Mann GV:  Coronary heart disease in the Framingham Study: A symposium on measuring the risk of coronary heart disease in adult population groups . Am J Public Health 1957;;47:4-24.
27 +
Shurtleff D:  Some characteristics related to the incidence of cardiovascular disease and death , in Kannel WB, Gordon T (eds): The Framingham Study: Eighteen-Year Follow-up , publication 74-599. National Institutes of Health, 1974;, pp 83-124.
28 +
Kesteloot H, Lee CS, Park HM, et al:  A comparative study of serum lipids between Belgium and Korea . Circulation 1982;;65:795-799.
29 +
O'Dea KO, Spargo RM, Nestel PJ:  Impact of westernization of carbohydrate and lipid metabolism in Australian aborigines . Diabetologia 1982;;22:148-153.
30 +
Albrink MJ, Meigs JW, Granoff MA:  Weight gain and serum triglycerides in normal men . N Engl J Med 1962;;266:484-489.
31 +
Gillum RF, Taylor HL, Brozek J:  Blood lipids in young men followed 32 years . J Chronic Dis 1982;;35:635-641.
32 +
Glueck CJ, Gartside P, Laskarzewski P, et al:  High density lipoprotein cholesterol in blacks and whites: Potential ramifications for coronary heart disease . Am Heart J , in press.
33 +
Body weight, stature, and sitting height: White and Negro youths 12-17 years, United States. Vital Health Stat 11, 1973.
34 +
Sims EAH, Goldman RF, Gluch CM, et al:  Experimental obesity in men . Trans Assoc Am Physicians 1968;;81:153-170.
35 +
Matter S, Weltman A, Stamford BA:  Body fat content and serum lipid levels . J Am Diet Assoc 1980;;77:149-152.
36 +
Morrison JA, deGroot I, Kelly KA, et al:  Black-white differences in plasma lipoproteins in Cincinnati school children (one-to-one pair-matched by total plasma cholesterol, sex, and age) . Metabolism 1979;;28:241-245.
37 +
Morrison JA, deGroot I, Kelly KA, et al:  Black-white differences in plasma lipids and lipoproteins in adults: The Cincinnati Lipid Research Clinic population study . Prev Med 1979;;8:34-39.
38 +
Garn SM, Bailey SM, Higgens ITT:  Effects of socioeconomic status, family line, and living together on fatness and obesity , in Lauer RM, Shekelle RB (eds): Childhood Prevention of Atherosclerosis and Hypertension . New York, Raven Press, 1980;, pp 187-204.
39 +
Khoury P, Morrison JA, Laskarzewski PM, et al:  Parent-offspring and sibling body mass index associations during and after sharing of common household environments: The Princeton school district family study . Metabolism 1983;; 32:82-89.

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