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October 14, 1983, Vol 250, No. 14 >
ARTICLE | October 14, 1983

Lipid Research Clinics Program Reference Values for Hyperlipidemia and Hypolipidemia FREE

Basil M. Rifkind, MD, FRCP; Pesach Segal, MD
[+] Author Affiliations

Reprint requests to Lipid Metabolism—Atherogenesis Branch, Division of Heart and Vascular Disease, National Heart, Lung, and Blood Institute, Bethesda, MD 20205 (Dr Rifkind).


JAMA. 1983;250(14):1869-1872. doi:10.1001/jama.1983.03340140039025
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References

Plasma cholesterol and triglyceride distributions have been established for 60,502 participants in a survey of ten separate, well-defined North American populations. Lipoprotein cholesterol levels were measured in a 7,055-person random sample of the white participants. From these data, new age- and sex-specific reference values have been selected for the diagnosis of hyperlipidemia and hypolipidemia. The use of these new reference values for population screening would result in the conditions of more young subjects being diagnosed as hypercholesterolemic and a very significant decrease in the proportion of the adult population being diagnosed as having hypertriglyceridemia.

(JAMA 1983;250:1869-1872)

REFERENCES

1 +
Kannel WB, Dawber TR, Friedman GD, et al:  Risk factors in coronary heart disease: An evaluation of several serum lipids as predictors of coronary heart disease . Ann Intern Med 1964;;61:888-899.
2 +
Gordon T, Castelli WP, Hjortland MC, et al:  High density lipoprotein as a protective factor against coronary heart disease . Am J Med 1977;;62:707-714.
3 +
Lippel K, Tyroler HA, Eder G, et al:  Meeting summary: Relationship of hypertriglyceridemia to atherosclerosis . Arteriosclerosis 1981;;1:406-417.
4 +
Heiss G, Tamir I, Davis CE, et al:  Lipoprotein-cholesterol distributions in selected North American populations: The Lipid Research Clinics Program Prevalence Study . Circulation 1980;; 61:302-315.
5 +
Lipid Research Clinics Program:  The Prevalence Study , vol 1 in The Lipid Research Clinics Population Studies Data Book , NIH publication 80-1527. Bethesda, Md, US Dept of Health and Human Services, 1980;.
6 +
Williams OD, Mowery RL, Waldman GT:  Common methods, different populations: The Lipid Research Clinics Program Prevalence Study . Circulation 1980;;62( (suppl 4) ):IV-18-IV-23.
7 +
Lipid Research Clinics Program:  Lipid and Lipoprotein Analysis , vol 1, in Manual of Laboratory Operations . NIH publication 75-628, Bethesda, Md, US Dept of Health and Human Services, 1974 (revised (Oct) 1982;)
8 +
Lippel K, Ahmed S, Albers JJ, et al:  Analytical performance and comparability of the determination of cholesterol by 12 lipid research clinics . Clin Chem 1977;;23:1744-1752.
9 +
Ahmed S, Lippel K, Bachorik P, et al:  Analytical performance and comparability of the determination of triglycerides by 12 lipid research clinic laboratories . Clin Chem 1978;; 24:330-338.
10 +
Lippel K, Ahmed S, Albers JJ, et al:  External quality control survey of cholesterol analyses performed by 12 lipid research clinics . Clin Chem 1978;;24:1477-1484.
11 +
Ahmed S, Lippel K, Bachorik PS, et al:  External quality control survey of triglyceride (triacylglycerol) analyses performed by 12 lipid research clinics . Clin Chem 1979;;25:880-888.
12 +
Laboratory Methods Committee of the Lipid Research Clinics Program:  Cholesterol and triglyceride concentrations in serum/plasma pairs . Clin Chem 1977;;23:60-63.
13 +
SAS Supplemental Library Users' Guide . Cary, NC, Statistical Analysis System Institute Inc, 1979;.
14 +
Feinleib M:  Summary of a workshop on cholesterol and noncardiovascular disease mortality . Prev Med 1982;;11:360-367.
15 +
Siervogel RM, Morrison JA, Kelly K, et al:  Familial hyperalpha-lipoproteinemia in 26 kindreds . Clin Genet 1980;;17:13.
16 +
The Pooling Project Research Group:  Relationship of blood pressure, serum cholesterol, smoking habit, relative weight, and ECG abnormalities to incidence of major coronary events: Final report of the Pooling Project . J Chronic Dis 1978;;31:201-306.
17 +
Fredrickson DS, Levy RI:  Familial hyperlipoproteinemia , in Stanbury JB, Wyngaarden JB, Fredrickson DS (eds): The Metabolic Basis of Inherited Disease , ed 3. New York, McGraw-Hill Book Co Inc, 1972;, pp 545-614.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Kannel WB, Dawber TR, Friedman GD, et al:  Risk factors in coronary heart disease: An evaluation of several serum lipids as predictors of coronary heart disease . Ann Intern Med 1964;;61:888-899.
2 +
Gordon T, Castelli WP, Hjortland MC, et al:  High density lipoprotein as a protective factor against coronary heart disease . Am J Med 1977;;62:707-714.
3 +
Lippel K, Tyroler HA, Eder G, et al:  Meeting summary: Relationship of hypertriglyceridemia to atherosclerosis . Arteriosclerosis 1981;;1:406-417.
4 +
Heiss G, Tamir I, Davis CE, et al:  Lipoprotein-cholesterol distributions in selected North American populations: The Lipid Research Clinics Program Prevalence Study . Circulation 1980;; 61:302-315.
5 +
Lipid Research Clinics Program:  The Prevalence Study , vol 1 in The Lipid Research Clinics Population Studies Data Book , NIH publication 80-1527. Bethesda, Md, US Dept of Health and Human Services, 1980;.
6 +
Williams OD, Mowery RL, Waldman GT:  Common methods, different populations: The Lipid Research Clinics Program Prevalence Study . Circulation 1980;;62( (suppl 4) ):IV-18-IV-23.
7 +
Lipid Research Clinics Program:  Lipid and Lipoprotein Analysis , vol 1, in Manual of Laboratory Operations . NIH publication 75-628, Bethesda, Md, US Dept of Health and Human Services, 1974 (revised (Oct) 1982;)
8 +
Lippel K, Ahmed S, Albers JJ, et al:  Analytical performance and comparability of the determination of cholesterol by 12 lipid research clinics . Clin Chem 1977;;23:1744-1752.
9 +
Ahmed S, Lippel K, Bachorik P, et al:  Analytical performance and comparability of the determination of triglycerides by 12 lipid research clinic laboratories . Clin Chem 1978;; 24:330-338.
10 +
Lippel K, Ahmed S, Albers JJ, et al:  External quality control survey of cholesterol analyses performed by 12 lipid research clinics . Clin Chem 1978;;24:1477-1484.
11 +
Ahmed S, Lippel K, Bachorik PS, et al:  External quality control survey of triglyceride (triacylglycerol) analyses performed by 12 lipid research clinics . Clin Chem 1979;;25:880-888.
12 +
Laboratory Methods Committee of the Lipid Research Clinics Program:  Cholesterol and triglyceride concentrations in serum/plasma pairs . Clin Chem 1977;;23:60-63.
13 +
SAS Supplemental Library Users' Guide . Cary, NC, Statistical Analysis System Institute Inc, 1979;.
14 +
Feinleib M:  Summary of a workshop on cholesterol and noncardiovascular disease mortality . Prev Med 1982;;11:360-367.
15 +
Siervogel RM, Morrison JA, Kelly K, et al:  Familial hyperalpha-lipoproteinemia in 26 kindreds . Clin Genet 1980;;17:13.
16 +
The Pooling Project Research Group:  Relationship of blood pressure, serum cholesterol, smoking habit, relative weight, and ECG abnormalities to incidence of major coronary events: Final report of the Pooling Project . J Chronic Dis 1978;;31:201-306.
17 +
Fredrickson DS, Levy RI:  Familial hyperlipoproteinemia , in Stanbury JB, Wyngaarden JB, Fredrickson DS (eds): The Metabolic Basis of Inherited Disease , ed 3. New York, McGraw-Hill Book Co Inc, 1972;, pp 545-614.

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