Basophilic-Eosinophilic Meningitis in an Undifferentiated Myeloproliferative Disorder FREE

Jeffrry P. Jaffe, MD; Charles L. Loprinzi, MD

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JAMA. 1983;249(1):73-74. doi:10.1001/jama.1983.03330250053029

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ABSTRACT

ABSTRACT | REFERENCES

BASOPHILIA and eosinophilia are common findings during an "accelerated phase" of chronic myeloproliferative disorders, particularly chronic myelogenous leukemia.^1,2 When these diseases involve the meninges, it is invariably as "leukemic meningitis," usually during the blastic transformation to acute leukemia, and blasts are the primary cell found in the CSF.³ A case of an undifferentiated myeloproliferative disorder (Philadelphia chromosome negative) occurred, in which the terminal event was characterized by a severe infiltration of the meninges with basophils and, to a lesser extent, eosinophils, without the presence of leukemic blasts.

Report of a Case A 40-year-old woman was seen at the hospital 2 1/2 years before her present admission with vaginal bleeding, leukocytosis (116,000/cu mm, with 1% blast forms, 2% myelocytes, 9% metamyelocytes, 34% band forms, 38% polymorphonuclear leukocytes, 3% lymphocytes, 2% monocytes, 1% basophils, and 2% eosinophils), thrombocytosis (3,500,000/cu mm), a normal bone marrow karyotype, a leukocyte alkaline phosphatase score

REFERENCES

ABSTRACT | REFERENCES

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Budka H, Guseo A, Jellinger K, et al: Intermittent meningitic reaction with severe basophilia and eosinophilia in CNS leukemia . J Neurol Sci 1976;;28:459-468.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal