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ARTICLE |

Amenorrhea Associated With Carotenemia FREE

Ekkehard Kemmann, MD; Samuel A. Pasquale, MD; Robert Skaf, MD
[+] Author Affiliations

Reprint requests to Department of Obstetrics and Gynecology, Rutgers Medical School, MEB, New Brunswick, NJ 08903 (Dr Kemmann).


JAMA. 1983;249(7):926-929. doi:10.1001/jama.1983.03330310056029
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Data are presented for ten women with anovulation, nine of them with amenorrhea, who have associated carotenemia. Classic explanations for carotenemia in amenorrheic patients have been weight loss or anorexia nervosa, yet carotenemia in our patients appeared to be diet induced. All patients consumed a pure or predominantly vegetarian diet; there was no intake of red meats. Clinical and laboratory data of the patients are presented. The amenorrhea of the patient is consistent with hypothalamic hypogonadotropic anovulation (HHA). It appeared that diet modification not only led to reduction in carotene levels, but also improved the menstrual status. The association of carotenemia and menstrual disorders is reviewed. The possibility that carotenemia is related to the development of HHA is discussed.

(JAMA 1983;249:926-929)

REFERENCES

Jeghers H:  Skin changes of nutritional origin . N Engl J Med 1943;;228:678-686.
Almond S, Logan RFL:  Carotenemia . Br Med J 1942;;2:239-241.
Cohen L:  Observation on carotenemia . Ann Intern Med 1958;;48:219-227.
Pops MA, Schwabe AD:  Hypercarotenemia in anorexia nervosa . JAMA 1968;;205:533-534.
Grant JP, Custer PB, Thurlow J:  Current techniques of nutritional assessment . Surg Clin North Am 1981;;61:437-463.
Hess AF, Myers VC:  Carotenemia: A new clinical picture . JAMA 1919;;73:1743-1745.
Frumar AM, Meldrum DR, Judd HL:  Hypercarotenemia in hypothalamic amenorrhea . Fertil Steril 1979;;32:261-264.
Robboy MS, Sato AS, Schwabe AD:  The hypercarotenemia in anorexia nervosa: A comparison of vitamin A and carotene levels in various forms of menstrual dysfunction and cachexia . Am J Clin Nutr 1974;;27:362-367.
Page SW:  Golden ovaries . Aust NZ J Obstet Gynecol 1971;;11:32-36.
Herrmann W: Discussion to Romney SL, Palan PR, Duttagapta C, et al:  Retinoids and the prevention of cervical dysplasias . Am J Obstet Gynecol 1981;;141:894.

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Jeghers H:  Skin changes of nutritional origin . N Engl J Med 1943;;228:678-686.
Almond S, Logan RFL:  Carotenemia . Br Med J 1942;;2:239-241.
Cohen L:  Observation on carotenemia . Ann Intern Med 1958;;48:219-227.
Pops MA, Schwabe AD:  Hypercarotenemia in anorexia nervosa . JAMA 1968;;205:533-534.
Grant JP, Custer PB, Thurlow J:  Current techniques of nutritional assessment . Surg Clin North Am 1981;;61:437-463.
Hess AF, Myers VC:  Carotenemia: A new clinical picture . JAMA 1919;;73:1743-1745.
Frumar AM, Meldrum DR, Judd HL:  Hypercarotenemia in hypothalamic amenorrhea . Fertil Steril 1979;;32:261-264.
Robboy MS, Sato AS, Schwabe AD:  The hypercarotenemia in anorexia nervosa: A comparison of vitamin A and carotene levels in various forms of menstrual dysfunction and cachexia . Am J Clin Nutr 1974;;27:362-367.
Page SW:  Golden ovaries . Aust NZ J Obstet Gynecol 1971;;11:32-36.
Herrmann W: Discussion to Romney SL, Palan PR, Duttagapta C, et al:  Retinoids and the prevention of cervical dysplasias . Am J Obstet Gynecol 1981;;141:894.
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