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Rhesus Diploid Rabies Vaccine (Adsorbed), A New Rabies Vaccine: Title and subTitle BreakII. Results of Clinical Studies Simulating Prophylactic Therapy for Rabies Exposure FREE

Byron S. Berlin, MD; John R. Mitchell, DVM; George H. Burgoyne, PhD; William E. Brown, MD; Claude Goswick, MD
[+] Author Affiliations

Reprint requests to Laboratory and Epidemiological Services Administration, Michigan Department of Public Health, 3500 N Logan St, Lansing, MI 48909 (Dr Berlin).


JAMA. 1983;249(19):2663-2665. doi:10.1001/jama.1983.03330430039026
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Rhesus diploid-cell-strain rabies vaccine (RDRV) (adsorbed) is a new rabies vaccine intended for use in man. Sixty volunteers were given five doses of RDRV at 0, 3, 7, 14, and 28 days to simulate prophylactic treatment of persons exposed to a rabid animal. Thirty-five volunteers were given commercial high-titer rabies immune globulin, 20 IU/kg, before the first dose of RDRV, and 25 were given RDRV without prior rabies immune globulin. Antibody responses at 14, 28, and 42 days were comparable with those reported with human diploid rabies vaccine. Simulated postexposure prophylactic treatment with RDRV was associated with acceptable levels of local and constitutional symptoms.

(JAMA 1983;249:2663-2665)

REFERENCES

Berlin BS, Mitchell JR, Burgoyne GH, et al:  Rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine: Results of initial clinical studies of preexposure vaccination . JAMA 1982;;247:1726-1728.
Wallace RE, Vasington PJ, Petricciani JC, et al:  Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production . In Vitro 1973;;8:323-332.
Recommendation of the Immunization Practices Advisory Committee (ACIP):  Rabies prevention . MMWR 1980;;29:265-281.
Kuwert FK, Marcus I, Hoher PC:  Neutralizing and complement-fixing antibody responses in pre- and post-exposure vaccinees to a rabies vaccine produced in human diploid cells . J Biol Stand 1976;;4:249-263.
Hafkin B, Hattwick MA, Smith JS, et al:  A comparison of a WI-38 vaccine and duck embryo vaccine for pre-exposure rabies prophylaxis . Am J Epidemiol 1978;;107:439-443.
Anderson LJ, Winkler WG, Hafkin B, et al:  Clinical experience with a human diploid cell rabies vaccine . JAMA 1980;;244:781-784.
Aoki FY, Tyrrell DA, Hill LE:  Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers . Lancet 1975;;1:660-662.
 Adverse reactions to human diploid cell rabies vaccine . MMWR 1980;;29:609-610.
Boe E, Nyland H:  Guillain-Barré syndrome after vaccination with human diploid cell rabies vaccine . Scand J Infect Dis 1980;;12:231-232.

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Berlin BS, Mitchell JR, Burgoyne GH, et al:  Rhesus diploid rabies vaccine (adsorbed), a new rabies vaccine: Results of initial clinical studies of preexposure vaccination . JAMA 1982;;247:1726-1728.
Wallace RE, Vasington PJ, Petricciani JC, et al:  Development of a diploid cell line from fetal rhesus monkey lung for virus vaccine production . In Vitro 1973;;8:323-332.
Recommendation of the Immunization Practices Advisory Committee (ACIP):  Rabies prevention . MMWR 1980;;29:265-281.
Kuwert FK, Marcus I, Hoher PC:  Neutralizing and complement-fixing antibody responses in pre- and post-exposure vaccinees to a rabies vaccine produced in human diploid cells . J Biol Stand 1976;;4:249-263.
Hafkin B, Hattwick MA, Smith JS, et al:  A comparison of a WI-38 vaccine and duck embryo vaccine for pre-exposure rabies prophylaxis . Am J Epidemiol 1978;;107:439-443.
Anderson LJ, Winkler WG, Hafkin B, et al:  Clinical experience with a human diploid cell rabies vaccine . JAMA 1980;;244:781-784.
Aoki FY, Tyrrell DA, Hill LE:  Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers . Lancet 1975;;1:660-662.
 Adverse reactions to human diploid cell rabies vaccine . MMWR 1980;;29:609-610.
Boe E, Nyland H:  Guillain-Barré syndrome after vaccination with human diploid cell rabies vaccine . Scand J Infect Dis 1980;;12:231-232.
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