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Prolonged Bleeding Times and Bleeding Diathesis Associated With Moxalactam Administration FREE

Michael R. Weitekamp, MD; Robert C. Aber, MD
[+] Author Affiliations

Reprint requests to Department of Medicine, The Pennsylvania State University, Hershey, PA 17033 (Dr Weitekamp).


JAMA. 1983;249(1):69-71. doi:10.1001/jama.1983.03330250049027
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A reversible bleeding diathesis associated with marked prolongation of the bleeding time was recognized in five patients receiving the new antibiotic moxalactam disodium (Moxam). Platelet dysfunction secondary to interference with adenosine diphosphate-induced aggregation has been demonstrated in vitro. Clinically important hemorrhage consequent to the use of this antibiotic may be more common than previously thought.

(JAMA 1983;249:69-71)

REFERENCES

Kumar R, Ansell JE, Canoso RT, et al:  Clinical trial of a new bleeding-time device . Am J Clin Pathol 1978;;70:642-645.
McClure PD, Casserly JG, Monsier C, et al:  Carbenicillin-induced bleeding disorder . Lancet 1970;;2:1307-1308.
Brown CH, Bradshaw MW, Natelson EA, et al:  Defective platelet function following the administration of penicillin compounds . Blood 1976;;47:949-956.
Brown CH, Natelson EA, Bradshaw MW, et al:  The hemostatic defect produced by carbenicillin . N Engl J Med 1974;;291:265-270.
Bang NU, Tessler SS, Heidenrich RO, et al:  Effects of moxalactam on blood coagulation and platelet function , abstracted. Rev Infect Dis , in press.
Packham MA, Mustard FJ:  Clinical pharmacology of platelets . Blood 1977;;50:555-573.

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Kumar R, Ansell JE, Canoso RT, et al:  Clinical trial of a new bleeding-time device . Am J Clin Pathol 1978;;70:642-645.
McClure PD, Casserly JG, Monsier C, et al:  Carbenicillin-induced bleeding disorder . Lancet 1970;;2:1307-1308.
Brown CH, Bradshaw MW, Natelson EA, et al:  Defective platelet function following the administration of penicillin compounds . Blood 1976;;47:949-956.
Brown CH, Natelson EA, Bradshaw MW, et al:  The hemostatic defect produced by carbenicillin . N Engl J Med 1974;;291:265-270.
Bang NU, Tessler SS, Heidenrich RO, et al:  Effects of moxalactam on blood coagulation and platelet function , abstracted. Rev Infect Dis , in press.
Packham MA, Mustard FJ:  Clinical pharmacology of platelets . Blood 1977;;50:555-573.
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