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November 19, 1982, Vol 248, No. 19 >
ARTICLE | November 19, 1982

Interferon—The First Quarter Century FREE

Thomas C. Merigan, MD
[+] Author Affiliations

Reprint requests to the Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305 (Dr Merigan).


JAMA. 1982;248(19):2513-2516. doi:10.1001/jama.1982.03330190067040
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References

THERE has been interest in the therapeutic potential of interferon since Isaacs and Lindenmann first described this substance in 1957.1 However, the supply of interferon for clinical trials has been very limited until the last year or so. Ironically, the short supply of material during the past quarter century still allowed more fundamental background knowledge to be accrued for interferon than for any other therapeutic agent previously studied in man. Many studies using in vitro and animal models of human disease were undertaken, but the number of clinical studies was few, and these were small in scale. These studies used crude material and, as reviewed here, showed biologic activity of interferon in man by showing a beneficial effect in a limited number of viral and neoplastic diseases. The most striking effects were obtained in animals when interferon was applied early in the disease process, that is, either before the

REFERENCES

1 +
Isaacs A, Lindemann J:  Virus interference: The interferon . Proc R Soc Lond Biol 1957;;147:258-267.
2 +
Dunnick JK, Merigan TC, Galasso GJ:  Report of a workshop on DNA recombinant technology in interferon cloning . J Infect Dis 1981;;143:297-300.
3 +
Tommila V:  Treatment of dendritic keratitis with interferon . Acta Ophthalmol 1963;;41:478-482.
4 +
Tyrrell DAJ, Phillpotts R:  Antirhinovirus drugs . J Antimicrob Chemother 1982;;9:340-341.
5 +
Merigan TC, Rand KH, Pollard RB, et al:  Human leukocyte interferon for the treatment of herpes zoster in patients with cancer . N Engl J Med 1978;;298:981-987.
6 +
Merigan TC, Gallagher JG, Pollard RB, et al:  Short-course human leukocyte interferon in treatment of herpes zoster in patients with cancer . Antimicrob Agents Chemother 1981;;19:193-195.
7 +
Pazin GJ, Armstrong JA, Lam MT, et al:  Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root . N Engl J Med 1979;;301:225-230.
8 +
Cheeseman SH, Rubin RH, Stewart JA, et al:  Controlled clinical trial of prophylactic human leukocyte interferon in renal transplantation: Effects on cytomegalovirus and herpes simplex virus infections . N Engl J Med 1979;;300:1345-1349.
9 +
Arvin AM, Kushner JH, Feldman S, et al:  Human leukocyte interferon for the treatment of varicella in children with cancer . N Engl J Med 1982;;306:761-765.
10 +
Emodi G, O'Reilly R, Muller A, et al:  Effect of human exogenous leukocyte interferon in cytomegalovirus infections . J Infect Dis 1976;; 133( (suppl) ):A199-A204.
11 +
Arvin AM, Yeager AS, Merigan TC:  Effect of leukocyte interferon on urinary excretion of cytomegalovirus in infants . J Infect Dis 1976;; 133( (suppl) ):A205-A210.
12 +
Smith CI, Kitchen LW, Scullard GH, et al:  Vidarabine monophosphate and human leukocyte interferon in chronic hepatitis B infection . JAMA 1982;;247:2261-2265.
13 +
Merigan TC, Sikora K, Breeden JH, et al:  Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin's lymphoma . N Engl J Med 1978;;229:1449-1453.
14 +
Gutterman JU, Blumenschein GR, Alexanian R, et al:  Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma and malignant lymphoma . Ann Intern Med 1980;; 93:339-406.
15 +
Borden EC, Holland JF, Dao TL, et al:  Leukocyte-derived interferon (alpha) in human breast carcinoma . Ann Intern Med 1982;;97:1-6.
16 +
Mellstedt H, Bjorkholm M, Johansson B, et al:  Interferon therapy in myelomatosis . Lancet 1979;;1:245-247.
17 +
Hill NO, Pardue A, Khan A, et al:  High-dose human leukocyte interferon trials in leukemia and cancer . Med Pediatr Oncol 1981;;9:82.
18 +
Haglund S, Lundquist PG, Cantell K, et al:  Interferon therapy in juvenile laryngeal papillomatosis . Arch Otorhinolaryngol , in press.
19 +
Marx JL:  Is RNA copied into DNA by mammalian cells? Science 1982;;216:969-970.
20 +
Horning SJ, Levine JF, Miller RA, et al:  Clinical and immunologic effects of recombinant leukocyte A interferon in eight patients with advanced cancer . JAMA 1982;;247:1718-1722.
21 +
Gutterman JU, Fine S, Quesada J, et al:  Recombinant leukocyte A interferon: Pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients . Ann Intern Med 1982;;96:549-556.
22 +
Fleischmann WR Jr, Georgiades JA, Osborne LC, et al:  Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon . Infect Immun 1979;;26:949-955.
23 +
Lerner TJ:  Interferon . Genetic Engineering News 1982;;2:16-17.
24 +
Stevens DA, Merigan TC:  Interferon, antibody and other host factors in herpes zoster . J Clin Invest 1972;;51:1170-1178.
25 +
Fleischmann WR Jr:  Potentiation of the direct anticellular activity of mouse interferons: Mutual synergism and interferon concentration dependence . Cancer Res 1982;;42:869-875.
26 +
Chany C, Bourgeade M, Cerutti I:  Enhancement of the biological effects of interferon by associated treatments , in Khan A, Hill NO, Dorn GL (eds): Interferon: Properties and Clinical Uses . Dallas, Leland Fikes Foundation Press, 1979;, pp 267-277.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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1 +
Isaacs A, Lindemann J:  Virus interference: The interferon . Proc R Soc Lond Biol 1957;;147:258-267.
2 +
Dunnick JK, Merigan TC, Galasso GJ:  Report of a workshop on DNA recombinant technology in interferon cloning . J Infect Dis 1981;;143:297-300.
3 +
Tommila V:  Treatment of dendritic keratitis with interferon . Acta Ophthalmol 1963;;41:478-482.
4 +
Tyrrell DAJ, Phillpotts R:  Antirhinovirus drugs . J Antimicrob Chemother 1982;;9:340-341.
5 +
Merigan TC, Rand KH, Pollard RB, et al:  Human leukocyte interferon for the treatment of herpes zoster in patients with cancer . N Engl J Med 1978;;298:981-987.
6 +
Merigan TC, Gallagher JG, Pollard RB, et al:  Short-course human leukocyte interferon in treatment of herpes zoster in patients with cancer . Antimicrob Agents Chemother 1981;;19:193-195.
7 +
Pazin GJ, Armstrong JA, Lam MT, et al:  Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root . N Engl J Med 1979;;301:225-230.
8 +
Cheeseman SH, Rubin RH, Stewart JA, et al:  Controlled clinical trial of prophylactic human leukocyte interferon in renal transplantation: Effects on cytomegalovirus and herpes simplex virus infections . N Engl J Med 1979;;300:1345-1349.
9 +
Arvin AM, Kushner JH, Feldman S, et al:  Human leukocyte interferon for the treatment of varicella in children with cancer . N Engl J Med 1982;;306:761-765.
10 +
Emodi G, O'Reilly R, Muller A, et al:  Effect of human exogenous leukocyte interferon in cytomegalovirus infections . J Infect Dis 1976;; 133( (suppl) ):A199-A204.
11 +
Arvin AM, Yeager AS, Merigan TC:  Effect of leukocyte interferon on urinary excretion of cytomegalovirus in infants . J Infect Dis 1976;; 133( (suppl) ):A205-A210.
12 +
Smith CI, Kitchen LW, Scullard GH, et al:  Vidarabine monophosphate and human leukocyte interferon in chronic hepatitis B infection . JAMA 1982;;247:2261-2265.
13 +
Merigan TC, Sikora K, Breeden JH, et al:  Preliminary observations on the effect of human leukocyte interferon in non-Hodgkin's lymphoma . N Engl J Med 1978;;229:1449-1453.
14 +
Gutterman JU, Blumenschein GR, Alexanian R, et al:  Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma and malignant lymphoma . Ann Intern Med 1980;; 93:339-406.
15 +
Borden EC, Holland JF, Dao TL, et al:  Leukocyte-derived interferon (alpha) in human breast carcinoma . Ann Intern Med 1982;;97:1-6.
16 +
Mellstedt H, Bjorkholm M, Johansson B, et al:  Interferon therapy in myelomatosis . Lancet 1979;;1:245-247.
17 +
Hill NO, Pardue A, Khan A, et al:  High-dose human leukocyte interferon trials in leukemia and cancer . Med Pediatr Oncol 1981;;9:82.
18 +
Haglund S, Lundquist PG, Cantell K, et al:  Interferon therapy in juvenile laryngeal papillomatosis . Arch Otorhinolaryngol , in press.
19 +
Marx JL:  Is RNA copied into DNA by mammalian cells? Science 1982;;216:969-970.
20 +
Horning SJ, Levine JF, Miller RA, et al:  Clinical and immunologic effects of recombinant leukocyte A interferon in eight patients with advanced cancer . JAMA 1982;;247:1718-1722.
21 +
Gutterman JU, Fine S, Quesada J, et al:  Recombinant leukocyte A interferon: Pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients . Ann Intern Med 1982;;96:549-556.
22 +
Fleischmann WR Jr, Georgiades JA, Osborne LC, et al:  Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon . Infect Immun 1979;;26:949-955.
23 +
Lerner TJ:  Interferon . Genetic Engineering News 1982;;2:16-17.
24 +
Stevens DA, Merigan TC:  Interferon, antibody and other host factors in herpes zoster . J Clin Invest 1972;;51:1170-1178.
25 +
Fleischmann WR Jr:  Potentiation of the direct anticellular activity of mouse interferons: Mutual synergism and interferon concentration dependence . Cancer Res 1982;;42:869-875.
26 +
Chany C, Bourgeade M, Cerutti I:  Enhancement of the biological effects of interferon by associated treatments , in Khan A, Hill NO, Dorn GL (eds): Interferon: Properties and Clinical Uses . Dallas, Leland Fikes Foundation Press, 1979;, pp 267-277.

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