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October 1, 1982, Vol 248, No. 13 >
ARTICLE | October 1, 1982

Intradermal Immunization With Human Diploid Cell Rabies Vaccine: Title and subTitle BreakSerological and Clinical Responses of Persons With and Without Prior Vaccination With Duck Embryo Vaccine FREE

Michael J. Burridge, BVM&S, MPVM, PhD; George M. Baer, DVM, MPH; John W. Sumner; Oscar Sussman, DVM, MPH, JD
[+] Author Affiliations

Reprint requests to College of Veterinary Medicine, Box J-136, University of Florida, Gainesville, FL 32610 (Dr Burridge).


JAMA. 1982;248(13):1611-1614. doi:10.1001/jama.1982.03330130059028
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References

Intradermal administration of human diploid cell rabies vaccine (HDCV) was investigated in an attempt to reduce the current high cost of preexposure rabies prophylaxis. The study population consisted of 240 volunteers from a veterinary hospital, 165 of whom had prior vaccination with duck embryo rabies vaccine (DEV). Vaccine safety was good; only minor reactions were experienced, all of which resolved spontaneously. Serological responses to intradermal HDCV were excellent; 209 (99.5%) of the 210 persons who completed the study produced rabies antibody titers of 0.50 IU/mL or greater (range, 0.50 to 40.00 IU/mL). Two 0.1-mL doses of HDCV given intradermally 28 days apart provide a safe, effective, and economical method for human preexposure prophylaxis against rabies, irrespective of the previous DEV vaccination history of the recipient.

(JAMA 1982;248:1611-1614)

REFERENCES

1 +
Anderson LJ, Sikes RK, Langkop CW, et al:  Postexposure trial of a human diploid cell strain rabies vaccine . J Infect Dis 1980;;142:133-138.
2 +
Recommendation of the Immunization Practices Advisory Committee (ACIP):  Rabies prevention . MMWR 1980;;29:265-272, 277-280.
3 +
Mann JM, Hoffman RE, Rollag OJ, et al:  The advent of human diploid cell rabies vaccine: Impact on vaccine utilization in New Mexico . Am J Public Health 1981;;71:423-424.
4 +
Aoki FY, Tyrrell DAJ, Hill LE, et al:  Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers . Lancet 1975;;1:660-662.
5 +
Cox JH, Schneider LG:  Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine . J Clin Microbiol 1976;;3:96-101.
6 +
Turner GS, Aoki FY, Nicholson KG, et al:  Human diploid cell strain rabies vaccine: Rapid prophylactic immunisation of volunteers with small doses . Lancet 1976;;1:1379-1381.
7 +
Nicholson KG, Turner GS, Aoki FY:  Immunization with a human diploid cell strain of rabies virus vaccine: Two-year results . J Infect Dis 1978;;137:783-788.
8 +
Ajjan N, Soulebot JP, Triau R, et al:  Intradermal immunization with rabies vaccine: Inactivated Wistar strain cultivated in human diploid cells . JAMA 1980;;244:2528-2531.
9 +
Smith JS, Yager PA, Baer GM:  A rapid reproducible test for determining rabies neutralizing antibody . Bull WHO 1973;;48:535-541.
10 +
Sinnecker H, Atanasiu P, Bahmanyar M, et al:  Vaccine potency requirements for reduced immunization schedules and pre-exposure treatment , in Hennessen W, Regamey RH (eds): Joint WHO/IABS Symposium on the Standardization of Rabies Vaccines for Human Use Produced in Tissue Culture (Rabies III) . Basel, Switzerland, S Karger AG, 1978;, pp 268-270.
11 +
Rubin RH, Hattwick MAW, Jones S, et al:  Adverse reactions to duck embryo vaccine: Range and incidence . Ann Intern Med 1973;; 78:643-649.
12 +
Garner WR, Jones DO, Pratt E:  Problems associated with rabies pre-exposure prophylaxis . JAMA 1976;;235:1131-1132.
13 +
Tierkel ES, Sikes RK:  Preexposure prophylaxis against rabies: Comparison of regimens . JAMA 1967;;201:911-914.
14 +
Hafkin B, Hattwick MAW, Smith JS, et al:  A comparison of a WI-38 vaccine and duck embryo vaccine for preexposure rabies prophylaxis . Am J Epidemiol 1978;;107:439-443.
15 +
Rosanoff E, Tint H:  Response to human diploid cell rabies vaccine: Neutralizing antibody responses of vaccinees receiving booster doses of human diploid cell rabies vaccine . Am J Epidemiol 1979;;110:322-327.
16 +
Bernard KW, Roberts MA, Sumner JW, et al:  Effectiveness of immunization with small intradermal or subcutaneous doses of a human diploid-cell rabies vaccine . JAMA 1982;;247:1138-1142.

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1 +
Anderson LJ, Sikes RK, Langkop CW, et al:  Postexposure trial of a human diploid cell strain rabies vaccine . J Infect Dis 1980;;142:133-138.
2 +
Recommendation of the Immunization Practices Advisory Committee (ACIP):  Rabies prevention . MMWR 1980;;29:265-272, 277-280.
3 +
Mann JM, Hoffman RE, Rollag OJ, et al:  The advent of human diploid cell rabies vaccine: Impact on vaccine utilization in New Mexico . Am J Public Health 1981;;71:423-424.
4 +
Aoki FY, Tyrrell DAJ, Hill LE, et al:  Immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers . Lancet 1975;;1:660-662.
5 +
Cox JH, Schneider LG:  Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine . J Clin Microbiol 1976;;3:96-101.
6 +
Turner GS, Aoki FY, Nicholson KG, et al:  Human diploid cell strain rabies vaccine: Rapid prophylactic immunisation of volunteers with small doses . Lancet 1976;;1:1379-1381.
7 +
Nicholson KG, Turner GS, Aoki FY:  Immunization with a human diploid cell strain of rabies virus vaccine: Two-year results . J Infect Dis 1978;;137:783-788.
8 +
Ajjan N, Soulebot JP, Triau R, et al:  Intradermal immunization with rabies vaccine: Inactivated Wistar strain cultivated in human diploid cells . JAMA 1980;;244:2528-2531.
9 +
Smith JS, Yager PA, Baer GM:  A rapid reproducible test for determining rabies neutralizing antibody . Bull WHO 1973;;48:535-541.
10 +
Sinnecker H, Atanasiu P, Bahmanyar M, et al:  Vaccine potency requirements for reduced immunization schedules and pre-exposure treatment , in Hennessen W, Regamey RH (eds): Joint WHO/IABS Symposium on the Standardization of Rabies Vaccines for Human Use Produced in Tissue Culture (Rabies III) . Basel, Switzerland, S Karger AG, 1978;, pp 268-270.
11 +
Rubin RH, Hattwick MAW, Jones S, et al:  Adverse reactions to duck embryo vaccine: Range and incidence . Ann Intern Med 1973;; 78:643-649.
12 +
Garner WR, Jones DO, Pratt E:  Problems associated with rabies pre-exposure prophylaxis . JAMA 1976;;235:1131-1132.
13 +
Tierkel ES, Sikes RK:  Preexposure prophylaxis against rabies: Comparison of regimens . JAMA 1967;;201:911-914.
14 +
Hafkin B, Hattwick MAW, Smith JS, et al:  A comparison of a WI-38 vaccine and duck embryo vaccine for preexposure rabies prophylaxis . Am J Epidemiol 1978;;107:439-443.
15 +
Rosanoff E, Tint H:  Response to human diploid cell rabies vaccine: Neutralizing antibody responses of vaccinees receiving booster doses of human diploid cell rabies vaccine . Am J Epidemiol 1979;;110:322-327.
16 +
Bernard KW, Roberts MA, Sumner JW, et al:  Effectiveness of immunization with small intradermal or subcutaneous doses of a human diploid-cell rabies vaccine . JAMA 1982;;247:1138-1142.

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