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ARTICLE |

Pure Red Cell Aplasia Associated With Sodium Valproate Therapy FREE

Lorna G. MacDougall, MB, ChB, DCH
[+] Author Affiliations

Reprint requests to the Metabolic and Nutrition Research Unit, Baragwanath Hospital, PO Bertsham 2013, South Africa (Dr MacDougall).


JAMA. 1982;247(1):53-54. doi:10.1001/jama.1982.03320260037026
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Pure red cell aplasia developed in a 9-year-old girl receiving sodium valproate therapy. Infection with measles and chickenpox had occurred two months previously. Regeneration of bone marrow erythroid precursors was demonstrated one month after drug withdrawal. Readministration of sodium valproate resulted in a second episode of red cell aplasia that again resolved promptly after drug withdrawal. The respective roles of infection and drugs in the etiology of red cell aplasia are discussed.

(JAMA 1982;247:53-54)

REFERENCES

Sparberg M:  Diagnostically confusing complications of diphenlhydantoin therapy . Ann Intern Med 1963;;59:914-930.
Gordon RL, Kahn SB:  Hematologic effects of anticonvulsant drugs , in Dimitrov NV, Nodine JH (eds): Drugs and Hematologic Reactions . New York, Grune & Stratton Inc, 1974;, p 155.
Brittingham TE, Lutcher CL, Murphy DL:  Reversible erythroid aplasia induced by Dilantin . Arch Intern Med 1964;;113:764-781.
Jeong Y-G, Jung Y, River GL:  Pure RBC aplasia and diphenylhydantoin . JAMA 1974;; 229:314-315.
Richardson SGN, Fletcher DJ, Jeavons PM, et al:  Sodium valproate and platelet function . Br Med J 1976;;1:221-222.
Von Voss H, Petrich C, Karch D, et al:  Sodium valproate and platelet function . Br Med J 1976;;2:179.
Alter BP, Potter NU, Li FP:  Classification and aetiology of aplastic anaemias . Clin Haematol 1978;;3:431-465.
Wang WC, Mentzer WC:  Differentiation of transient erythroblastopenia of childhood from congenital hypoplastic anemia . J Pediatr 1976;; 88:784-789.
Koenig HM, Lightsey AL, Nelson DP, et al:  Immune suppression of erythropoiesis in transient erythroblastopenia of childhood . Blood 1979;;54:742-746.
Yunis AA, Arimura GK, Lutcher CL, et al:  Biochemical lesion in dilantin-induced erythroid aplasia . Blood 1967;;30:587-600.

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Sparberg M:  Diagnostically confusing complications of diphenlhydantoin therapy . Ann Intern Med 1963;;59:914-930.
Gordon RL, Kahn SB:  Hematologic effects of anticonvulsant drugs , in Dimitrov NV, Nodine JH (eds): Drugs and Hematologic Reactions . New York, Grune & Stratton Inc, 1974;, p 155.
Brittingham TE, Lutcher CL, Murphy DL:  Reversible erythroid aplasia induced by Dilantin . Arch Intern Med 1964;;113:764-781.
Jeong Y-G, Jung Y, River GL:  Pure RBC aplasia and diphenylhydantoin . JAMA 1974;; 229:314-315.
Richardson SGN, Fletcher DJ, Jeavons PM, et al:  Sodium valproate and platelet function . Br Med J 1976;;1:221-222.
Von Voss H, Petrich C, Karch D, et al:  Sodium valproate and platelet function . Br Med J 1976;;2:179.
Alter BP, Potter NU, Li FP:  Classification and aetiology of aplastic anaemias . Clin Haematol 1978;;3:431-465.
Wang WC, Mentzer WC:  Differentiation of transient erythroblastopenia of childhood from congenital hypoplastic anemia . J Pediatr 1976;; 88:784-789.
Koenig HM, Lightsey AL, Nelson DP, et al:  Immune suppression of erythropoiesis in transient erythroblastopenia of childhood . Blood 1979;;54:742-746.
Yunis AA, Arimura GK, Lutcher CL, et al:  Biochemical lesion in dilantin-induced erythroid aplasia . Blood 1967;;30:587-600.
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