0
ARTICLE |

Ethylene Glycol Poisoning FREE

R. Todd Light, MD; Kay M. Nelson, MT (ASCP); John H. Eckfeldt, MD, PhD
[+] Author Affiliations

Edited by John D. Archer, MD, Senior Editor.


JAMA. 1981;246(16):1769-1769. doi:10.1001/jama.1981.03320160011008
Text Size: A A A
Published online

To the Editor.—  We read the recent case reports of massive ethylene glycol ingestion by Stokes and Aueron (1980;243:2065) and by Peterson et al.1 Our own experience in a recent ethylene glycol poisoning, where the diagnosis was not evident from the patient's history and made only post mortem, caused us to review the clinical indications and available methods for ethylene glycol determination. A metabolic acidosis value with a high anion gap and a substantial discrepancy between the measured and calculated osmolality is suggestive of ethylene glycol or methyl alcohol intoxication. In either case, one must often start therapy with the infusion of ethyl alcohol, correction of the acidosis with sodium bicarbonate, and preparation for dialysis before there is laboratory confirmation.If a gas chromatograph is available for volatile toxins, a change in the usual screening conditions will include ethylene glycol among the identifiable poisons. As usually performed, volatile screens

REFERENCES

Peterson CD, Collins AJ, Himes JM, et al:  Ethylene glycol poisoning: Pharmacokinetics during therapy with ethanol and hemodialysis . New Engl J Med 1981;;304:21-23.
Scully RE, Galdabini JJ, McNeely BU (eds):  Case records of the Massachusetts General Hospital: Case 38-1979 . New Engl J Med 1979;;301:650-657.
Freidman EA, Greenberg JB, Merrill JP, et al:  Consequences of ethylene glycol poisoning: Report of four cases and review of the literature . Am J Med 1962;;32:891-902.
Eckfeldt JH, Light RT:  Kinetic ethylene glycol assay with use of yeast alcohol dehydrogenase . Clin Chem 1980;;26:1278-1280.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Peterson CD, Collins AJ, Himes JM, et al:  Ethylene glycol poisoning: Pharmacokinetics during therapy with ethanol and hemodialysis . New Engl J Med 1981;;304:21-23.
Scully RE, Galdabini JJ, McNeely BU (eds):  Case records of the Massachusetts General Hospital: Case 38-1979 . New Engl J Med 1979;;301:650-657.
Freidman EA, Greenberg JB, Merrill JP, et al:  Consequences of ethylene glycol poisoning: Report of four cases and review of the literature . Am J Med 1962;;32:891-902.
Eckfeldt JH, Light RT:  Kinetic ethylene glycol assay with use of yeast alcohol dehydrogenase . Clin Chem 1980;;26:1278-1280.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.